Protein
Lon protease homolog 2, peroxisomal
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Function
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
Similarity
Belongs to the peptidase S16 family.
Sequence
MGLFFDSPGSNLYLPCFTLVDAPKLVPLPGVSYKVSFERDSIIHVLSEFKRNNSFKNNHLLDKINTAIAQNEIVVDNSVVNSCKQFHKKYGSDNSNNDAEVQMYIVLLPFEAVNNSVGAASRITAIQVEDDTITITFKSVARVENKQPLLNMQHSLWKSSILEIDDRSELRTWDHKSINKSILSFVKIFYDTDKIIKDFKSKYSLASKRSGDIDSRVLYLSPLANTLFMQLNGSHFNKSWKLLKAYLEQLTVLERNYDTCFELVSMMDLVMSILPMSLKQRLDFLTAKKLKSRAILFSTCVQDFQQIFKKLDDSVDYVNNHFSNSSNNDKSKLIANQLRALRFYIDDIKRNNSSVILKANSEKERTDVTSPNKFLKTSSSHDEDSDSNDEMEQIKSFIDSLEEKNVHPDGIKLLQKDFKRFMKMTPQNADYQVLRNYFDIVMDIPFGKTVNISTIDLAKSRAKLNEDHYGLQSVKRRLVEYLSVLKISEISTNDPNLNTDLHPKKDRASINKPPILLLVGPPGVGKTSIAKSVADVLGRKFQRISLGGIHNEAEIRGHRRTYVGSMCGLIIGALRKAGTMNPLILLDEVDKVLSGGVGGFGNRVNGDPGAALLEVLDPEQNSTFSDHYVGFPVDLSQVLFFCTANDLEGISEPLLNRMELIELPGYTPDEKIMIGSKFLLPKQIKANGLDAIKELPKIYLTDEAWNCVVLEYTREPGVRGLERRIGAIVRGKVVEYVENKMIQGEVDKEHLYKYLGLAHHPISEEILAPTEHSEKFGVVNGLSYNSDGSGSVLLFEVIKIHTDESGATNGPYIKTTGNLGNILEESIKIATSFVKHILFRGLIPGVNEKDINEFLTSEYHLHVPMGAVSKDGPSAGAAISLAILSCALKRPVSPKLCMTGEITLRGKILPIGGIKEKLLGAQFYHMNHVLVPSANLSDVVQAVSTDNQEQYEIYMDRSRQPELQKLKDKTQLQLHYCSDFFDVVKYTWPELLNKEVSHSRPSL