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KLHL40

Gene
KLHL40
Protein
Kelch-like protein 40
Organism
Homo sapiens
Length
621 amino acids
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:23746549). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity).
Similarity
Belongs to the KLHL40 family.
Mass
69.257 kDa
Sequence
MALGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDAHEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKWEGVLREIAYAAGATFLPVRLNVLCLTKM

Gene
Klhl40
Protein
Kelch-like protein 40
Organism
Mus musculus
Length
621 amino acids
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:25940086). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (PubMed:25940086). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (PubMed:24960163).
Similarity
Belongs to the KLHL40 family.
Mass
69.589 kDa
Sequence
MTLGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRVGEREFPCHRLVLAACSPYFRARFLAEPDSAGEVRLEEVSPDVVSQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLANCLAVFRLGLLLDCARLAVAARDFICARFPLVARDNDFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWASSGDAEAQAERQRALPTVFESVRCRLLPRAFLETRVERHPLVRSQPELLRKVQMVKDAHEGRLTTLRKKKKEKGEQTARAKEANQGTEDTKAEDDEERVLPGILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSTQIPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNAIYVVGGRELKDSEDSLDSVLCYDRLSFKWGESDPLPYAVYGHTVLSHMDLVYVIGGKGKDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIFVAAGVTDTGLTSSSEVYSIADNKWTSFEAFPQERSSLSLVSLAGTLYALGGFATLETESGELVPTELNDIWRYNEDEKKWEGVLREIAYAAGATFLPVRLNVVRLTKM

Gene
klhl40
Protein
Kelch-like protein 40
Organism
Xenopus laevis
Length
614 amino acids
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development.
Similarity
Belongs to the KLHL40 family.
Mass
69.7 kDa
Sequence
MALPTQQSEELRLYQQTLLQDGLKDMLDHNNFIDCVLKIQGKEFPCHRLVLASCSPYFRAMFLSDLEESKKKEIDLEDVDPDVMGKILHYIYTSEIEITEKNVQDIFSVANMFQIPSIFTVCVSFLQKKLCLSNCLAIFRLGLLLDCPRLAVSARDFVCDRFNLIARDSELYELSPDELIAVISSDSLNIEKEEDVFEVVMKWASKEKEKRTKALPVIFESIRFCLIPQDYIKNKVEKHELVKPNKELLKKLQIVKDAQQGKLPSLKKKTSAKASEGKDGEQVVNGELDEEEEALPGILNDTLRFGMFLKDMIFMISDTGAVAYDPSANECFFASLSAQIPKNHVSLATKENQLFVAGGLYYNEESKEEPLSSYFLQFDHLDSDWLGMPPVPSARCLFGLGESENSIYLIGGKELKEGEQMLDSVLCYDRPSFKWGESDPLPYKVYGHTVVSHDNLVYVLGGKGNEKKCLKRVCVYNPKKFEWKDLAPMKTGRSLFGATVHKGKIFIAAGVTDTGLTNTIEAYDIKTNKWEDFTEFPQERSSLSLVSMNGTLYAIGGFATIENESEELVPTELNDIWRFNEEEKKWEGILREIRYASGATFIAARLNILRLTKM

Gene
klhl40
Protein
Kelch-like protein 40
Organism
Xenopus tropicalis
Length
614 amino acids
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development.
Similarity
Belongs to the KLHL40 family.
Mass
69.547 kDa
Sequence
MALPTQQADELRLYQQTLLQDGLKDMLDHDNFIDCVLKIQGKEFPCHRLVLAACSPYFRAMFLSNLEEGKKKEIDLEDVDPDVMGKILHYIYTSEIEITEKNVQDIFSVANMFQIPSIFTVCVSFLQKKLCLSNCLAIFRLGLLLDCPRLAVSARDFVCDRFHLIARDEEFYDLSPDELIAVISSDSLNIEKEEEVFEVVLKWALKEKEKRAKALPIIFESIRFRLIPQDYIKNKVEKHELVKSDKELLKKLQMVKDAQEGKLPAAVKKTPSKASEGKDGEGVVNGDLEEEEEALPGILNDTLRFGMFLKDMIFMISDTGAVAYDPSANECFFASLSAQIPKNHVSLATKENQLFVAGGLYYNEENKDDPLSSYFLQFDHLDSDWLGMPPVPSARCLFGLGESDNSIYLIGGKELKEGEQTLDTVLCYDRPSFKWGESDPLPYQVYGHTVVSHDNLVYVLGGKGNEKKCLKRVCVYNPKKFEWKDLAPMKTARSLFGSTVHKGKILIAAGVTDTGLTNTIEAYDVKTNKWEEFTEFPQERSSLSLVSMNGTLYAIGGFATTENESGEFVPTELNDIWRFNEEEKKWEGILREIRYASGATFVAARLNILRLTKM