About Products Protein Database Contact

KLHL25

Gene
KLHL25
Protein
Kelch-like protein 25
Organism
Homo sapiens
Length
589 amino acids
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Mass
65.923 kDa
Sequence
MSVSVHETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWKHLPA
Protein
Kelch-like protein 25: KLHL25

Gene
Klhl25
Protein
Kelch-like protein 25
Organism
Mus musculus
Length
589 amino acids
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Mass
65.826 kDa
Sequence
MSVSVHETRKSRSSTGSMNISVFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQRKAHLPLLLRNVRLALLPSDCLKNAVSGEALLMADECTKLILDEAFRCKTKILLNDGVVTSPFARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGIFPASPSVSLKQVEKYDPGDNKWTMVAPMRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCFDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEYTAASAYRFDCETNQWTRIGDMTAKRMSCHAVASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWKHLPA
Protein
Kelch-like protein 25: Klhl25

Gene
Klhl25
Protein
Kelch-like protein 25
Organism
Rattus norvegicus
Length
589 amino acids
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (By similarity).
Mass
65.84 kDa
Sequence
MSVSVHETRKSRSSTGSMNISVFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQRKVHLPLLLRNVRLALLPSDCLKKAVSGEALLMADECTKLIIDEAFRCKTKILLNDGVVTSPFARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGIFPASPSVSLKQVEKYDPGDNKWTMVAPMRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCFDPSDNRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEYTAASAYRFDCETNQWTRIGDMTAKRMSCHAVASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITSVPYSLIPTAFVSTWKHLPA
Protein
Kelch-like protein 25: Klhl25

Gene
klhl25
Protein
Kelch-like protein 25
Organism
Xenopus laevis
Length
589 amino acids
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated eif4ebp1 (4E-BP1) (By similarity).
Mass
66.081 kDa
Sequence
MSVSVHENRKSRTSTGSMNISLYHKLSHSECVLNHLNTMRKQRLFTDMTLWAGNRSFPCHRAVLAACSPYFEAMFSNGLRESLDNTVNFHNSLHPEVLELLLDFAYSSKIIINEENAESLLEAGDMLQFHDVRDAACEFLEKNLYPSNCLGMMILSDAHQCQRLYELSLRMCLSNFATLHNTEDFSSLSKDMLLDLISSDELEIEDEQVVFNAVLHWVKEDLDKRKDYFPELLRNVRLALLPSELLKEAVVCEDLIIADERSKLIMDEAVQCKKKILQNDGVVTSLCAKPRKAGHTLLILGGQTFMCDKIYQLDHKAKEIIPKADLPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTIHEEWSKSAPMLIARFGHGSAELDNCLYVVGGHTAVAGVFPASPSVSLKQVEKYDPLPNKWTMMAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDRVSKVQFYDPHENRWSIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNLWTRIGDMTAKRMSCHALASGNKVYVVGGYFGTQRCKTLDCYDPTSDSWNSITSVPYSLIPTAFVSTWKHLPA
Protein
Kelch-like protein 25: klhl25

Gene
klhl25
Protein
Kelch-like protein 25
Organism
Xenopus tropicalis
Length
589 amino acids
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated eif4ebp1 (4E-BP1) (By similarity).
Mass
65.955 kDa
Sequence
MSVTVHENRKSRTSTGSMNISLYHKLSHSDCVLNHLNTMRKQRLFTDVTLWAGNRSFPCHRAVLAACSQYFEAMFSNGLRESLDNTVNFHDSLHPEVLELLLDFAYSSKIIINEENAESLLEAGDMLQFHDIRDAACEFLEKNLYPSNCLGMMILSDAHQCQRLYELSLRTCLSNFATLHNTEDFCSLSKDMVLDLISSDELEIEDEQVVFNSVLHWVKEDLDKRKDYFPELLRKVRLALLPSELLKEAVVCEDLIIADERSKLIMDEAVVCKKKILQNDGVVTSLCAKPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSACAIGCKVYVTGGRGSENGVSKDVWVYDTINEEWSKSAPMLIARFGHGSAELENCLYVVGGHTAVAGVFPASPSVSLKQVEKYDPLTNKWTMMAPLRDGVSNAAVVSAKLKLFAFGGTSIHRDRVSKVQCYDPDENRWSIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKVYVVGGYFGTQRCKTLDCYDPTSDSWNSITSVPYSLIPTAFVSTWKHLPA
Protein
Kelch-like protein 25: klhl25