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KIM2

Gene
KIM2
Protein
Depressant scorpion toxin BmKIM
Organism
Mesobuthus martensii
Length
85 amino acids
Function
Causes a slow progressive depressant flaccid paralysis, when injected into S.falculata blowfly larvae. Inhibits dose-dependently the total sodium (Nav) currents both in dorsal root ganglia neurons and in ventricular myocytes. Is toxic to mice by intravenous injection, but not by subcutaneous or intracerebroventricular injection. Produces antiarrhythmia in rat. Is then active on both mammals and insects.
Similarity
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family.
Mass
9.425 kDa
Sequence
MKLFLLLVFFASMLIDGLVNADGYIRGSNGCKISCLWGNEGCNKECKGFGAYYGYCWTWGLACWCEGLPDDKTWKSESNTCGGKK