Function
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Required for brassinosteroid (BR) signal transduction. Mediates ASK7/BIN2/SK21 inactivation both by competing with substrate binding (e.g. BZR1) and by promoting its ubiquitination and subsequent proteasomal degradation.
Sequence
MSDSDGKNMEGRFEAAYIVDLVRLILERLSFVDFHRARCVSSTWYVASKSVIGVTNPTTPWIILFPNKNVENNGSCKLFDPHENKTYIIRDLGFDMSTSRCLASSGSWFLMFDHRADFHLLNLFTRERILLPSLESIDGERYMRFKRPISGSHIEIDKAVLWVDDKSRDYFVFCNLSSYVAYHHKRGDDNNSWKVLQPIKHQGCVDMVFKESKLYMISAHQCLTVFDFSGGVSPVEMECASFGSSVCVNRFHMKYFSNLAVTLSGEVLIIVGGKMDSSPEAKCVFTVNKMDPKSSEFTVLIKSIGDEALLLDLGITVPAKDGVMRDCIYFSNDQYHRCCGISLRDGYNADRICVYQIGSDYVVQEFEHLTTSSTKLFKDARWFFPTFGDKCCFHLWILHPVILQAKKLQKSNLKGTKPVTREKTTIVNNVDGTTTQREKTTKGKNMIGKK