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KDM3A

Gene
KDM3A
Protein
Lysine-specific demethylase 3A
Organism
Gallus gallus
Length
1325 amino acids
Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).
Similarity
Belongs to the JHDM2 histone demethylase family.
Mass
149.333 kDa
Sequence
MVLRLEGSWSLLVGKRFLSLSGDDDGPWDTERVAEWPWQAGRIRAVSHTDISKPDLKICVEFDDESWEKRRWIEVYSPKMKVFLVEQKLVLAERRSHGGSISPVQWPAMTYKSLVDKAGLGPMVSIRYLGEEKCVFLSKDLLTPIQDVESSRLPLKDDQTVNEEIQALVKKHLDETRLVQGGKNIIGSKIRIYSLDPSTQWFTAVVVNGNPATRTLEVNCQEIPALKTLDPELIHVEIIYDNNGKCDKSKRIGGVKRKPSENSGSVDAKHTKSSPEVSQSQGHVHSVPTVFGEALLGCTPANKDQRHQGLPLPANSPPNLGAETPQGTCRRSVPEVHPSCLNAGTKPLKENLTLFPKVTYITKEQTQNINDQNGKYTSLISSRSSSLSDSTNGKETGLKNISEPLLKPTTNFPKECISAKPLQHLNSSIAIPRVNSSVELQRTLDCRPSTSDAHLLPFTEAGVRSHSGSNSQKGNKVDEHVEMEFFTRRNSNEAFYERNENESFWTGSTKIQDNVIVRKSILADASKVKKLQQSGEAFVQDGSCNNIAPHLHKCRECRLDSYRKNKDQKDSTVFCRFFHFRRLQFNKHGILREEGFLTPNKYDPEAISLWLPLSKNVVGLDLDTAKYILANIGDHFCQLVISEKEVMSTIEPHRQVAWKRAVRGVREMCDVCDTTIFNLRWVCSKCGFGVCVDCYRMRKKGIHEDDDSDTFSWFKCVKGQEHEPENLMPTQIIPGRALYDVGDIVHSVRTKWGIKANCPCANKQFKALSKPTLKEDSKQNLVPGERTSLQQSNLVLSPQLPTHEPPVKPAAGSKQTASVTTSPSLSWLSNITSGNVNKENKEKLLVPISKNENKALQTLPSLAKPAAALQTFNSAILTPVSNNNTGFLRNLLNSSGGKTDNGLKSTPKILDDIFASLVQNRTVTDMPKKPQGLTIKPTIMGFDTPHYWLCDNRLLCLQDPNNESNWNVFRECWKQGQPVMVSGVHHKLNADLWRPESFRKEFGQQEVDLVNCRTNEIITGATVGDFWDGFEDISSRLRTEEGEPMVLKLKDWPPGEDFRDMMPSRFDDLMKNIPLPEYTRRGGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQADQEEEVLKTIQDGDSDELTIKRFTESREKPGALWHIYAAKDTEKIREFLKKVAEEQGQENPVDHDPIHDQSWYLDRSLRKRLHQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRYLSHTHTNHEDKLQVKNVIYHAVKDAVGILRANESSLSRS

Gene
Kdm3a
Protein
Lysine-specific demethylase 3A
Organism
Mus musculus
Length
1323 amino acids
Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation (By similarity). Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin (PubMed:17943087). Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
Similarity
Belongs to the JHDM2 histone demethylase family.
Mass
147.847 kDa
Sequence
MVLTLGESWPVLVGKRFLSLSAAEGNEGGQDNWDLERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIDVYSLQRKAFLVEHNLVLAERKSPEVPEQVIQWPAIMYKSLLDKAGLGAITSVRFLGDQQSVFVSKDLLKPIQDVNSLRLSLTDNQTVSKEFQALIVKHLDESHLLQGDKNLVGSEVKIYSLDPSTQWFSATVVHGNPSSKTLQVNCEEIPALKIVDPALIHVEVVHDNFVTCGNSTRTGAVKRKSSENNGSSVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPSSKDPRQQNTPQAANSPPNIGAKLPQGCHKQNLPEELSSCLNTKPEVPRTKPDVCKEGLLSSKSSQVGAGDLKILSEPKGSCIQPKTNTDQESRLESAPQPVTGLPKECLPAKTSSKAELDIATTPELQKHLEHAASTSDDLSDKPEVKAGVTSLNSCAEKKVEPSHLGSQSQNLKETSVKVDNESCCTRSSNKTQTPPARKSVLTDPDKVRKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKDQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDSEAIGLWLPLTKNVVGTDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAYKTFSWIRCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPALKEDLKQTSLSGEKPTLGTMVQQSSPVLEPVAVCGEAASKPASSVKPTCPTSTSPLNWLADLTSGNVNKENKEKQLTMPILKNEIKCLPPLPPLNKPSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTAKTENGLKNTPKILDDIFASLVQNKTSSDSSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNTELWKPESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNDKEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEEEVLRTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQDNPADHDPIHDQSWYLDRSLRKRLYQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKASESSLGKP

Gene
KDM3A
Protein
Lysine-specific demethylase 3A
Organism
Homo sapiens
Length
1321 amino acids
Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
Similarity
Belongs to the JHDM2 histone demethylase family.
Mass
147.341 kDa
Sequence
MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLVEHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDESHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGTLVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCHKQSLPEEISSCLNTKSEALRTKPDVCKAGLLSKSSQIGTGDLKILTEPKGSCTQPKTNTDQENRLESVPQALTGLPKECLPTKASSKAELEIANPPELQKHLEHAPSPSDVSNAPEVKAGVNSDSPNNCSGKKVEPSALACRSQNLKESSVKVDNESCCSRSNNKIQNAPSRKSVLTDPAKLKKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKEQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDNEAIGLWLPLTKNVVGIDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAYKTFSWLKCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPASKEDLKQTSLAGEKPTLGAVLQQNPSVLEPAAVGGEAASKPAGSMKPACPASTSPLNWLADLTSGNVNKENKEKQPTMPILKNEIKCLPPLPPLSKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGLKNTPKILDDIFASLVQNKTTSDLSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNSELWKPESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEEEVLKTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQENPADHDPIHDQSWYLDRSLRKRLHQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKASESSFGKP

Gene
Kdm3a
Protein
Lysine-specific demethylase 3A
Organism
Rattus norvegicus
Length
1214 amino acids
Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Directly regulates expression of PPARA and UCP1 and is involved in obesity resistance (By similarity).
Similarity
Belongs to the JHDM2 histone demethylase family.
Mass
135.404 kDa
Sequence
MYKSLLDKAGLGSITSVRFLGDQQSVFVSKDLLKPIQDVNSLRLSLTDNQTVSKEFQALIVKHLDESHLLQGDKNLVGSEVRIYSLDPSTQWFSATVVHGNPSSKTLQVNCEEIPALKIVDPALIHVEVVHDNFVTCGNSTRIGAVKRKSSENNGSSVSKQAKSCSEVSPSMCPVQSVPTTVCKEILLGCTAATPSSNRQQNTPQAANSPPNIGAKLPQGCHKQSLPEEISSCLNTKSEVLRTKPDVCKAGLLSSKSSQVGAGDLKILSEPKGSCIQPKTNTDQESRLESTPQPVTGLTKECLVTKTSSKAELDNATAPELQKRLEHTASTPDGLSDKPEVEAGVTRLNSCSEKKVGPSDLGSQSQNLKETSVKVDHDSCCTRSSNKTQTPPARKSVLTDPDKLKKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKDQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDSEAIGLWLPLTKNVVGTDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRLKRKNCQQGAAYKTFSWIRCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPALKEDLKQASLSGEKPSLGTMVQQSSPVLEPAAVCGEAPSKPASNVKPICPANTSPLNWLADLTSGNVNKENKEKQLTMPILKNEIKCLPPLPPLNKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGLKNTPKILDDIFASLVQNKTSSDLSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNTELWKPESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNEKEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEEEVLRTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQENPADHDPIHDQSWYLDRSLRKRLYQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRHLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKAVNPVWANVNSSAHWR