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KATNA1

Gene
KATNA1
Protein
Katanin p60 ATPase-containing subunit A1
Organism
Strongylocentrotus purpuratus
Length
516 amino acids
Function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. In mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux.
Similarity
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Mass
57.593 kDa
Sequence
MSVDEICENTKMGREYALLGNYETSLVYYQGVLQQIQKLLTSVHEPQRKHQWQTIRQELSQEYEHVKNITKTLNGFKSEPAAPEPAPNHRAAPFSHHQHAAKPAAAEPARDPDVWPPPTPVDHRPSPPYQRAARKDPPRRSEPSKPANRAPGNDRGGRGPSDRRGDARSGGGGRGGARGSDKDKNRGGKSDKDKKAPSGEEGDEKKFDPAGYDKDLVENLERDIVQRNPNVHWADIAGLTEAKRLLEEAVVLPLWMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSASLTSKYHGESEKLVRLLFEMARFYAPSTIFIDEIDSICSKRGTGSEHEASRRVKSELLIQMDGVSGPSAGEESSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPEIDGREQLLRINLKEVPLADDIDLKSIAEKMDGYSGADITNVCRDASMMAMRRRIQGLRPEEIRHIPKEELNQPSTPADFLLALQKVSKSVGKEDLVKYMAWMEEFGSV

Gene
KATNA1
Protein
Katanin p60 ATPase-containing subunit A1
Organism
Gallus gallus
Length
492 amino acids
Function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
Similarity
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Mass
56.039 kDa
Sequence
MSLVMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSLRDTYLQQKWQQVWQEISVEAKHVKDIMKMLESFKIDSTPPKASQQELPAHDAEVWSLPVPAERRPSPGPRKRQSAQYSDCRGHNNRISAAVRGPHRPSSRNPNDKGKAVRGREKKDQQNKGKEEKSKSTSEISESEPKKFDSTGYDKDLVEALERDIISQNPNIRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGATENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRINLRELELADDVDLANIAEKMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSRDEMHMPTTMEDFEIALKKVSKSVSAADIEKYEKWIVEFGSC

Gene
KATNA1
Protein
Katanin p60 ATPase-containing subunit A1
Organism
Gallus gallus
Length
492 amino acids
Function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
Similarity
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Mass
56.039 kDa
Sequence
MSLVMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSLRDTYLQQKWQQVWQEISVEAKHVKDIMKMLESFKIDSTPPKASQQELPAHDAEVWSLPVPAERRPSPGPRKRQSAQYSDCRGHNNRISAAVRGPHRPSSRNPNDKGKAVRGREKKDQQNKGKEEKSKSTSEISESEPKKFDSTGYDKDLVEALERDIISQNPNIRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGATENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRINLRELELADDVDLANIAEKMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSRDEMHMPTTMEDFEIALKKVSKSVSAADIEKYEKWIVEFGSC

Gene
katna1
Protein
Katanin p60 ATPase-containing subunit A1
Organism
Xenopus tropicalis
Length
492 amino acids
Function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
Similarity
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Mass
56.162 kDa
Sequence
MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTFLQQKWQQVWQEINMEAKHVKDIMSTLEGFKLDNSPVKTTQHEFPAHDGEVWSLPVPVERRPSPGPRKRQSVQCNDNKSHNNRFGAGKGPNLPSSKNTNNVKMKPVRAREKKDTFLKVKDEKNKSSVDVSETEVKKFDGTGYDKDLIEALERDIISQNPNIRWDDIADLEEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNISSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENEDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRINLKELELADDVNIECIAENMDGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSRDDMHMPTTMEDFEMALKKVSKSVSASDIEKYEKWIEEFGSC

Gene
KATNA1
Protein
Katanin p60 ATPase-containing subunit A1
Organism
Homo sapiens
Length
491 amino acids
Function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
Similarity
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Mass
55.965 kDa
Sequence
MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC

Gene
KATNA1
Protein
Katanin p60 ATPase-containing subunit A1
Organism
Macaca fascicularis
Length
491 amino acids
Function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
Similarity
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Mass
55.909 kDa
Sequence
MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDSKSHGNRPGTTVRVHRSSAQNLHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC

Gene
Katna1
Protein
Katanin p60 ATPase-containing subunit A1
Organism
Mus musculus
Length
491 amino acids
Function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. The function in regulating microtubule dynamics at spindle poles seems to depend on the association of the katanin KATNA1:KATNB1 complex with ASPM which recruits it to microtubules. Reversely KATNA1:KATNB1 can enhance ASPM blocking activity on microtubule minus-end growth. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
Similarity
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Mass
55.949 kDa
Sequence
MSLQMIVENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTHLRQKWQQVWQEINVEAKQVKDIMKTLESFKLDITSLQAAQHELPAAEGEVWSLPVPVERRPLPGPRKRQSSQHSDPKPHSNRPSTVVRAHRPSPQNLHNDRGKAVRSREKKEQSKGREEKNKLPAAVTEPEANKFDGTGYDKDLVEALERDIISQNPNVRWYDIADLVEAKKLLQEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRMKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSREAMHMPTTMEDFEMALKKISKSVSAADIERYEKWIVEFGSC

Gene
Katna1
Protein
Katanin p60 ATPase-containing subunit A1
Organism
Rattus norvegicus
Length
491 amino acids
Function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
Similarity
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Mass
55.844 kDa
Sequence
MSLLMITENVKLAREYALLGNYDSAMVYYQGVLDQINKYLYSVKDTHLHQKWQQVWQEINVEAKHVKEIMKTLESFKLDSTSLKAAQHELPSSEGEVWSLPVPVERRPLPGPRKRQSTQHSDPKPHSNRPGAVVRAHRPSAQSLHSDRGKAVRSREKKEQSKGREEKNKLPAAVTEPEANKFDSTGYDKDLVEALERDIISQNPNVRWYDIADLVEAKKLLQEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSREEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIVEFGSC

Gene
katna1
Protein
Katanin p60 ATPase-containing subunit A1
Organism
Salmo salar
Length
486 amino acids
Function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
Similarity
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Mass
55.462 kDa
Sequence
MSLHEINENVKLAREYALLGNYSSAIVCYRGVLEQIKKYLFTVRDSSFQQKWQQVWQEINEENNQVQEIMRTLESFQLETTPSKPPSNQDGINDIWPVQVERRSSPLPVRRPPVPYKDSKPHNNRLSVAGVRAQHRQSPRGANGDRAKPLKGKEKKEAKPKDDKNKAEVSEKEVKRFDGQGYDKDLIEALERDIISQNPNVKWDDIADLEEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECRTTFFNVSSSTLTSKYRGESEKLVRILFEMARFYAPTTIFIDEIDSMCSRRGTSEEHEASRRVKAELLVQMDGVGGASDNEDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGRVELLRINLKELELANDVDMAKIAEQSEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNISRAEMHMPTTMEDFESSLKKVSKSVSASDLEKYEKWIEEFGSC

Gene
katna1
Protein
Katanin p60 ATPase-containing subunit A1
Organism
Xenopus laevis
Length
486 amino acids
Function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. In mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux.
Similarity
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Mass
55.43 kDa
Fragment
single
Sequence
MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTFLQQKWQQVWQEINMECKHVKDIMSTLEGFKLDSSPVKTTQHEFPSHDGEVWSLPVPVERRPSPGPRKRQSVQCNDNKSHNNRFSAAAKGPNLPSARNANNVKMKPVRAREKKDALIKNKSSADVSETEVKRFDGSGYDKDLIEALERDIISQNPNIRWDDIADLEEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNISSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENEDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRINLKELELADDVNIECIAENMDGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSRDDMHMPTTMEDFEMALKKVSKSVSASDIEKYEKWIFEFG

Gene
katna1
Protein
Katanin p60 ATPase-containing subunit A1
Organism
Danio rerio
Length
485 amino acids
Function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
Similarity
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Mass
54.882 kDa
Sequence
MSLGEINENVKLAREYALLGNYSSAVVCYQGVLEQIKKYLYSVRDSSLQQKWQQVWQEINEETKQVREIMTTLESFQMESTPSKPSSFAQDNDIMPVHVEHRSSPCVVRKSSVPYKDSKGHGNRLSVGPRGQARPSPRVANGDKGKPQKSKEKKENPSKPKEDKNKAEAVETEVKRFDRGGEDKDLIDALERDIISQNPNVTWDDIADLEEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECRTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGRVDLLKINLKELDLANDVNMDKIAEQMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLPKDEMHMPTTMEDFETALKKVSKSVSAADLEKYEKWIAEFGSC

Gene
katna1
Protein
Katanin p60 ATPase-containing subunit A1
Organism
Danio rerio
Length
485 amino acids
Function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
Similarity
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Mass
54.882 kDa
Sequence
MSLGEINENVKLAREYALLGNYSSAVVCYQGVLEQIKKYLYSVRDSSLQQKWQQVWQEINEETKQVREIMTTLESFQMESTPSKPSSFAQDNDIMPVHVEHRSSPCVVRKSSVPYKDSKGHGNRLSVGPRGQARPSPRVANGDKGKPQKSKEKKENPSKPKEDKNKAEAVETEVKRFDRGGEDKDLIDALERDIISQNPNVTWDDIADLEEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECRTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGRVDLLKINLKELDLANDVNMDKIAEQMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLPKDEMHMPTTMEDFETALKKVSKSVSAADLEKYEKWIAEFGSC