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Jmy

Gene
JMY
Protein
Junction-mediating and -regulatory protein
Organism
Homo sapiens
Length
988 amino acids
Function
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).
Similarity
Belongs to the JMY family.
Mass
111.445 kDa
Sequence
MSFALEETLESDWVAVRPHVFDEREKHKFVFIVAWNEIEGKFAITCHNRTAQRQRSGSREQAGARGGAEAGGAASDGSRGPGSPAGRGRPEATASATLVRSPGPRRSSAWAEGGSPRSTRSLLGDPRLRSPGSKGAESRLRSPVRAKPIPGQKTSEADDAAGAAAAAARPAPREAQVSSVRIVSASGTVSEEIEVLEMVKEDEAPLALSDAEQPPPATELESPAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGMWTVLFGGAPEMTEQEIDTLCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYYESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQMEDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSELPPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPETLEKDLPRKEGNEKRIPKSASAPSAHLFDSSQLVSARKKLRKTAEGLQRRRVSSPMDEVLASLKRGSFHLKKVEQRTLPPFPDEDDSNNILAQIRKGVKLKKVQKDVLRESFTLLPDTDPLTRSIHEALRRIKEASPESEDEEEALPCTDWEN

Gene
JMY
Protein
Junction-mediating and -regulatory protein
Organism
Homo sapiens
Length
988 amino acids
Function
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).
Similarity
Belongs to the JMY family.
Mass
111.445 kDa
Sequence
MSFALEETLESDWVAVRPHVFDEREKHKFVFIVAWNEIEGKFAITCHNRTAQRQRSGSREQAGARGGAEAGGAASDGSRGPGSPAGRGRPEATASATLVRSPGPRRSSAWAEGGSPRSTRSLLGDPRLRSPGSKGAESRLRSPVRAKPIPGQKTSEADDAAGAAAAAARPAPREAQVSSVRIVSASGTVSEEIEVLEMVKEDEAPLALSDAEQPPPATELESPAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGMWTVLFGGAPEMTEQEIDTLCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYYESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQMEDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSELPPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPETLEKDLPRKEGNEKRIPKSASAPSAHLFDSSQLVSARKKLRKTAEGLQRRRVSSPMDEVLASLKRGSFHLKKVEQRTLPPFPDEDDSNNILAQIRKGVKLKKVQKDVLRESFTLLPDTDPLTRSIHEALRRIKEASPESEDEEEALPCTDWEN

Gene
Jmy
Protein
Junction-mediating and -regulatory protein
Organism
Mus musculus
Length
983 amino acids
Function
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
Similarity
Belongs to the JMY family.
Mass
110.586 kDa
Sequence
MSFALEETLESDWVAVRPHVFDEREKHKFVFIVAWNEIEGKFAITCHNRTAQRQRSGSREQAGTPASDGSRGPGSPAARGRSEAAASATAALRSPGPRKSQAWAEGGSPRSARSLKGDPPRGPAGRGPESPLRSPARAKASPLRRSAESRDAIASATPVPPAPPVPPVSSVRVVSASGAVSEEIEVLEMVREDEAPQPLPDSEQPPSAAELESSAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGMWTVLFGGAPEMTEQEIDALCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYYESLSELRQKGYEEVLQRARRRIQELLDKHKTIESMVELLDLYQMEDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQKKHALKEEMQSLQGGTEAIARLDQLESDYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASVHAQREELQKLQQKARQLEARRGRVSAKKAYLRNKKEICIAKHHEKFQQRFQSEDEYRAHHTIQIKRDKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRVAHSRRKSTASPVPCEEQCHSLPTVLQGQEKTEVGGGGSQLGPSQTAEPQSLVQLEDTSSEQLESTSLPPRAVVSSELPPPQSAPLLTSIDPKPCSVTIDPLPPPLPPTPPPPPPPPPPPPPPLPVAKDNGASTTAETLEKDALRTEGNERSIPKSASAPAAHLFDSSQLVSARKKLRKTVEGLQRRRVSSPMDEVLASLKRGSFHLKKVEQRTLPPFPDEDDSNNILAQIRKGVKLKKVQKEVLRESFTLLPDTDPLTRSIHEALRRIKEASPESEDEEEALPCTDWEN

Gene
jmy
Protein
Junction-mediating and -regulatory protein
Organism
Danio rerio
Length
846 amino acids
Function
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics.
Similarity
Belongs to the JMY family.
Mass
96.38 kDa
Sequence
MSFAMEDAIESGWVSVRPNVFEEKEKHKFVFIVAWNEIEGKFAVTCHNRTVQKRSAERDSLLEAAEGELAAAADTDRRTARPAHRSPGRERSGGQSSPSAAAELELLDAAEDAELSARQDSSWAGLFSFQDLRAAHLQLCAVNADLEPCLPALPEEQTGVWSVLFGVPEMSARDTDALCFQLQVYLGHALDTCGWRILSQVLFPDSEDAEEYYESLSELRQKGYEDALQRAKRRLQQLLEQQRAVERMVELLQLYSEQDEAYGELVEATTELYHYLLQPFRDMRELAMLRRQQIKISLETERLGPRRVESLRREDEDWQRKAHTAVLSIQDLTVKYFETTARAQKVMYERMRADQRKFGKAAWGAAVERMERLQYAVSKETLQLMRAKEICLEQRKHGLREEMQGLQGGEDAMARLDQLEALYYELQLQLYEIQFEILKNEELLLTAQLQSLRRQMSERQEEVVYYDTFESPDAMKATEDPAQPQTPRDDINKLQQRTRQLEARRGRITAKKAYLKNKKEICIINHTQKLQQRQAGAHGVSQQPLLQDEEDEEEQRLSRVSQERQRTLDRLRSFKQRYPGQVTLKSTRLRLAFSRKKALRAEQMQTQTQPQTQAASVQTDDAPAPLEPPSAVPELCRPDSFLSLPPMGGAVAEAPPSAELTSLPPARELLLLDSSTSPMSPPPPPPPPPPPPPPMLEDFPPRSPPEPQSPLGPFSARFFDSSQLLNARKKLRKTASLESSQWRRASSPMDEVLASLKRGSFHLRKAELRVLAPDPDEDDGNNILAQIRKGVKLRKVRRQERSARAIMADSADPLTRSIHEALRRIKEASPESESEDDTPTATDWES

Gene
jmy
Protein
Junction-mediating and -regulatory protein
Organism
Danio rerio
Length
846 amino acids
Function
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics.
Similarity
Belongs to the JMY family.
Mass
96.38 kDa
Sequence
MSFAMEDAIESGWVSVRPNVFEEKEKHKFVFIVAWNEIEGKFAVTCHNRTVQKRSAERDSLLEAAEGELAAAADTDRRTARPAHRSPGRERSGGQSSPSAAAELELLDAAEDAELSARQDSSWAGLFSFQDLRAAHLQLCAVNADLEPCLPALPEEQTGVWSVLFGVPEMSARDTDALCFQLQVYLGHALDTCGWRILSQVLFPDSEDAEEYYESLSELRQKGYEDALQRAKRRLQQLLEQQRAVERMVELLQLYSEQDEAYGELVEATTELYHYLLQPFRDMRELAMLRRQQIKISLETERLGPRRVESLRREDEDWQRKAHTAVLSIQDLTVKYFETTARAQKVMYERMRADQRKFGKAAWGAAVERMERLQYAVSKETLQLMRAKEICLEQRKHGLREEMQGLQGGEDAMARLDQLEALYYELQLQLYEIQFEILKNEELLLTAQLQSLRRQMSERQEEVVYYDTFESPDAMKATEDPAQPQTPRDDINKLQQRTRQLEARRGRITAKKAYLKNKKEICIINHTQKLQQRQAGAHGVSQQPLLQDEEDEEEQRLSRVSQERQRTLDRLRSFKQRYPGQVTLKSTRLRLAFSRKKALRAEQMQTQTQPQTQAASVQTDDAPAPLEPPSAVPELCRPDSFLSLPPMGGAVAEAPPSAELTSLPPARELLLLDSSTSPMSPPPPPPPPPPPPPPMLEDFPPRSPPEPQSPLGPFSARFFDSSQLLNARKKLRKTASLESSQWRRASSPMDEVLASLKRGSFHLRKAELRVLAPDPDEDDGNNILAQIRKGVKLRKVRRQERSARAIMADSADPLTRSIHEALRRIKEASPESESEDDTPTATDWES

Gene
jmy
Protein
Junction-mediating and -regulatory protein
Organism
Xenopus tropicalis
Length
843 amino acids
Function
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics.
Similarity
Belongs to the JMY family.
Mass
96.693 kDa
Sequence
MSFNLEDTLESDWVAVRPNVFEEKERRKFVFIVAWNEVEGKFAITCHNRTAQRQRSADKAGGRSPARQQQRDSPAQSPARKAREEPEEGEEEECSWAGLFSFQDLRAVHQQLCSVSSELEPCLPTFPEEPSGVWSVLFGPSELSEAEVEDLGRQLRLYLGHALDTSGWKILSQVLFADSDDPEEYYQSLSELRHKGYEEGLQRARKRLQELLEKHKTTEVMVDLLDLYQLEDEAYSNVVEATTELYQYLLQPFRDMRELAMLRRQQIKISIENDYLGPRRIESLKKEDADWQKKAHMAVLSIQDLTVKYFEITARAQKAVFDRMRGDQKKFGKTAWAAAVERVEKLQYGVAKETLQLMRAKEICLEQKKHALKDQMQSLQGGTEAIAVLDELEADYYDHQLQLYEVQFEILKCEELLLTAQLESIKRQISEKTDEVVYYDTYESMEAMLATEDMAASIHIQRVELQKLQQKVRQLEAKRGRISAKKAYLRNKKEICIAKHSEKIQQRLHSDEGYRAAQLKQEKQEDEEERKSTWVSQERQKTLDRLRTFKQRHPGQVVLKSTRLRFSHERRRSTIRTTSSTDAPQSLSVSIQTQGLSDLGDTEVLQPIKTQKPETTTQLEDSSLPPNAITSELPLMTSLPTFTHEKLEPEISTLQPSSLPASPPPPPPPLPPPPPPPLPPSKQDTDTLEIRVIHVKKETEEKDGAKPVSGPLAQLFDSSQLLNARKTLKKTGALEGIQRRRVSSPMDEVLASLKRGSFHLKKVEQRALPPFPDEDESNNILAQIRKGVKLKKVQKEALRESFTLLPDTDPLTRSIHEALRRIKEASPESEDEEESLPCTDWEN