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JBP1

Gene
JBP1
Protein
Thymine dioxygenase JBP1
Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Length
839 amino acids
Function
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions.
Similarity
Belongs to the TET family. JBP1 subfamily.
Mass
95.251 kDa
Sequence
MRRQVKKVLREKADDSMKPGWDVYQPSNDVVYAFNHYMQGSQIDAEAREKAEKAFQEAVKKHPFHNNADHTVDFHGTTVFRNAKGKVCGVLIPKALPSFATSMAADVLECAVARTSLRSALFGGVSPNSGIAGYFDYRGTPVELKCRKTSFTYEHTKEWRSVFPMIDYTSAIYKAALPDHWKAQDAAVPDVVRIHGSPFSTLTVNERFRTASHTDNGDFDNGYGVLAVLKGEYSGLSLALDDYGVCFNMQPTDVLLFDTHLFHSNTELEAKEANATWNRLSCVFYYRAALGEQPCVEEYRRRLKKAKEEKSTSLSFNHIEQKDNGENTNKPAPVYPVSLTPFSCAASAWALRGCAAAMLTRLHGLVRENASLMTELFGEPVEVADGLPRRAPEEIIPVHKHTNVQMHYLGGFSEKGDILNEAMNKRHYLDKENLQKMFGEEFVNIWTQSRTHWLQLVKKEWEHQKETNPTRTRFSWNNTSAMNFAFFDLCDVAKQLMCGAFGDREVNKKEEQSFWGMFAAHLDNACINEIGMLQGSMGMHKLNVKLKDYNFGGTRYLKDMPPEEQERRRRRRLEIEQARRRAPICDSESGDWLRNEAFDYQTEDVAVNYEREQWITPENNAKRFGFPERGVYGAEGAATGTISVLIVLPKPTNHRQKTCELPTSREADRIMKNPAAQRLLCAKPCNIGLSTSSNKSRTVLCGNIRIDKVFDGGSVGGKMYDFVIMRHLLAATTGEREPLECLVRWTSLARYCTFVVEVDLLDRHHYILKSEIGEEYSAVSEICFSALYSATYARDKVNLRTTPCLLSFIDKSGNMLESRFKFNGSPLNTVAFVVRRREK

Gene
JBP1
Protein
Thymine dioxygenase JBP1
Organism
Trypanosoma brucei brucei
Length
839 amino acids
Function
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions.
Similarity
Belongs to the TET family. JBP1 subfamily.
Mass
95.23 kDa
Sequence
MRRQVKKVLREKADDSMKPGWDVYQPSNDVVYAFNHYMQGSQIDAEAREKAEKAFQEAVKKHPFHNNADHAVDFHGTTVFRNAKGKVCGVLIPKALPSFATSMAADVLECAVARTSLRSALFGGVSPNSGIAGYFDYRGTPVELKCRKTSFTYEHTKEWRSVFPMIDYTSAIYKAALPDHWKAQDAAVPDVVRIHGSPFSTLTVNERFRTASHTDNGDFDNGYGVLAVLKGEYSGLSLALDDYGVCFNMQPTDVLLFDTHLFHSNTELEAKEANATWNRLSCVFYYRAALGEQPCVEEYRRRLKKAKEEKSTSLSFNHIEQKDNGENTNKPAPVYPVPLTPFSCAASAWALRGCAAAMLTRLHGLVRENASLMTELFGEPVEVADGLPRRAPEEIIPVHKHTNVQMHYLGGFSEKGDILNEAMNKRHYLDKENLQKMFGEEFVNIWTQSRTHWLQLVKKEWEHQKETNPTRTRFSWNNTSAMNFAFFDLCDVAKQLMCGAFGDREVNKKEEQSFWGMFAAHLDNACINEIGMLQGSMGMHKLNVKLKDYNFGGTRYLKDMPPEEQERRRRRRLEIEQARRRAPICNSESGDWLRNEAFDYQTEDVAVNYEREQWITPENNAKRFGFPERGVYGAEGAATGTISVLIVLPKPTNHRQKTCELPTSREADRIMKNPAAQRLLCAKPCNIGLSTSSNKSRTVLCGNIRIDKVFDGGSVGGKMYDFVIMRHLLAATTGEREPLECLVRWTSLARYCTFVVEVDLLDRHHYILKSEIGEEYSAVSEICFSALYSATYARDKVNLRTTPCLLSFIDKSGNMLESRFKFNGSPLNTVAFVVRRREK

Gene
JBP1
Protein
Thymine dioxygenase JBP1
Organism
Leishmania tarentolae
Length
827 amino acids
Function
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions.
Similarity
Belongs to the TET family. JBP1 subfamily.
Mass
93.403 kDa
Sequence
MEPDSKKVKLDIFNFPTTRETRTPEEVAESYAEAVKSHPFYDNVHSVVDFYDSGTIKDGRGQIIGVVLREALPKYAASMASELLTSAAVRTSLRSMMFGGEPPLSGIAGYFDYRGSPVELKSRKTSFTYEHEAAWPAVFPVVDYVSEIYRHVAPERWKAQNDAIPDLVRIHGTPFSTLTINSRFRTASHTDVGDFDAGYSCIACLDGQFKGLALSFDDFGINVLLQPRDVMIFDSHHFHSNTEVELSFSGEDWKRLTCVFYYRAALGEPASYAEYQRRLEKSKTDTRFTPVVHHVRVKENGTSVNRPSPVYPISQSPFWVPMVAHCLQHCASAAQCVHEAMTADGSRLAEMMFGESLSTSDGIPLRGEDEKVKANGDSTPRPLSRLGGFSETNLMVSTAVEKKKYLDSEFLLHCISAQLLDMWKQARARWLELVGKEWAHMLALNPERKDFLWKNQSEMNSAFFDLCEVGKQVMLGLLGKEVALPKEEQAFWIMYAVHLSAACAEELHMPEVAMSLRKLNVKLKDFNFGGTRYFKDMPPEEKKRRMERKQRIEEARRHGMPSGSHEKRANWLTNDSFDYQTEDCVIDYAQHKWVLPALHAKEVTKTVRTGELPTTERVVRVLVVIPDPQSKLENVDCKLEVPDMVGSSSEWERLMSSPAVHRVLSAAQRNLQLPDSVTHGNVQTHFAFHSTLPTDIYDFVVLQHVLSRIPDDAQASAYIRRAAALCSGCLFVVETDVQCRQYYTLKYSIRCSYDTVAPLFFQQLHRVCYGTKTARVRTKGELESLIPTVCCARYKLQGSPLNTTVHVVSPFPSCEVQNLSSALCDRA

Gene
JBP1
Protein
Thymine dioxygenase JBP1
Organism
Leishmania infantum
Length
814 amino acids
Function
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions (By similarity).
Similarity
Belongs to the TET family. JBP1 subfamily.
Mass
91.928 kDa
Sequence
MEPDPKKVKLDIFDFPTARETRTPEEVAESYAEAVKSHPFYDNVHSAIDFYDSGTIKDGRGQIIGVVLREALPKYAASMASELLASAAVRTSLRSMMFGGESPLSGIAGYFDYRGSPVELKSRKTSFTYEHEAAWPAVFPVVDYVSELYRHVAPERWKAQNDAIPDVVRIHGTPFSTLTINSRFRTASHTDVGDFDGGYSCIACLDGQFKGLALAFDDFGINVLMQPRDVMIFDSHHFHSNTEVELSFSGEDWKRLTCVFYYRAALGEPASYAEYRRRLEKSKQDTSFTPVVSNVRVKENGTNLNRPSPVYPIFLSPFWVPMVAHCLQHCASEAQCVHDAMTADGSRLAEVMFGEPLSTSDGIPLRGEEEKLKANSDSASRPLSRLGGFSETNLMVSTAVEKKKYLNSEFLSHFISAQLLDMWKQARGKWLELVGREWTHMLALNPERKDFLWRNQSEMNSAFFDLCEVGKQVMLGLLGKEAALPKEEQAFWTMYAVHLNAACAEELNMPHVAMSLRKLNVKLKDFNFGGTRYFKDMPPEEQKRRMERKQRIEEARRHGMSSGAHEKRANWLTNDSFDYQTEDCVFDYAQHKWVPPALHAKEITKNVRSGELPTREGVVRVLVVLPDPQSKVDCVDCKLEVSETVRCSCEWERLMSSPAVHRVLAAAQRNLQLPDSVTHDNIEIRFAFHSRLPTDMCDFVVLQHVLSCIPDDVLASAYIRRSAALCSGCVFVVETDVQCRQYYTLKCSVRCDYDAVAPLFFQQLHRVSYGTKAARVRTKGELESLIPTVCCARYKLQGSPLNTTVHVVAPAPPR

Gene
JBP1
Protein
Thymine dioxygenase JBP1
Organism
Leishmania major
Length
814 amino acids
Function
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions (By similarity).
Similarity
Belongs to the TET family. JBP1 subfamily.
Mass
91.826 kDa
Sequence
MEPDPKKIKLDIFNFPTARETRTPEEVAESYAEAVKSHPFYDNVHSVIDFYDSGTIKDGRGQIIGVVLREALPKYAVSMASELLASAAVRTSLRSMMFGGESPLSGIAGYFDYRGSPVELKSRKTSFTYEHEAAWPAVFPVVDYVSELYRHVAPERWKAQNDAIPDVVRIHGTPFSTLTINSRFRTASHTDVGDFDGGYSCIACLDGHFKGLALAFDDFGINVLMQPRDVMIFDSHHFHSNTEVELSFSGEDWKRLTCVFYYRAALGEPASYAEYQRRLEKSKQDNSFTPVVSNVRVKENGTNLNRPSPVYPICPSPFWVPMVAHCLQHCASEAQCVHDAMTADGSRLAEVMFGEPLSTSDGIPLRGEDKKLKANSDSASRPLSRLGGFSETNLMVSTAVEKKKYLNSEFLSHFISAQLLDMWKQARGKWLELVGREWTHMLALNPERKDFLWKNQSEMNSAFFDLCEVGKQVMLGLLGKEVALPKEEQAFWTMYAVHLNAACAEELHMPHVAMSLRKLNVKLKDFNFGGTRYFKDMPPEEQKRRMERKQRIEEARRHGMSSGAHEKRANWLTNDSFDYQTEDCVVDYAQHKWPPPALHAKEITKNVRTGELPTREGVVRVLVVLPDPQSKLECVDCKLEVPETVRCSCEWERLMSSLAVRRVLAAAQRNLQLPGSVTHGNIEIRFAFHSRLPTDMCDFVVLQHVLSCIPDDVLASAYIRRAAALCTGCVYVVETDVQCRQYYTLKCAARCDYDAVASLFFQQLHRVSYGTKAARVRTKGELESLIPTVCCARYKLQGSPLNTTVHVVSPAPSR

Gene
JBP1
Protein
Thymine dioxygenase JBP1
Organism
Leishmania braziliensis
Length
813 amino acids
Function
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions (By similarity).
Similarity
Belongs to the TET family. JBP1 subfamily.
Mass
92.367 kDa
Sequence
MESSTKRIKMDIFNFPTIKETRTPEEVAESYAEAVKLHPFYDNAHCVIDFYDSGTIKDGRGEIIGVVLRKALPKYATSMASALLISAAVRTSLRSMIFGGESPLSGIAGYFDYRGSPVELKSRKTSFTYEHEEAWSAVFPVVDYVSEIYRHVAPERWKAQNNAIPDLVRIHGTPFSTLTINSRFRTASHTDVGDFDAGYSCIACIDGKFKGLALTFDDFRINVLMQPRDVMVFDSHHFHSNTEVEVSCSEEDWKRLTCVFYYRTALGEPSSYAEYRRRLEKSKQDPSFTPVVSNVMMKENGTNLNRPSPVHPVPPSPFWLPMLAHCLQHCASAAQSVHEAMTADGSQLAEIIFGEPLSTSDGIPLRGDDEKLKANGDTGAKPLSRLGGFSETDLMVSTAAEKRKYLDSEFLSHCISAQLLDMWKQARARWLELVGKEWKHMLTLNPERKDFLWKNRSEMNSAFFDLCEVGKQVMLGLLDKEAALPKEEQAFWTMYAVHLSAACAEELHMPHDAMSLRKLNVKLKDFNFGGTRYFKDMPPEEQQRRMERKQRIEEARRHGMTGAHEKRANWLTNDSFDYQTEDCVVDYAKHKWVLPERHAKAVTKNVHTAWLPTREEVVRVLVVLPDLQIRVEGVDCKLEKPDTVEDSSEWVRLVSSPAVHRLLAAAQRNLQLPDDVMHGNIHIRFVFHSTLPTDMYDFVVLQHVLSRIPDDVLASSYITRAAALCSGCLFVEETDVQCRQYYTLKYSIRRNYDAVAPHFFQQLHQASYGTKMARVRTKGELEALIPTVCCARYKLQGSPLNTTIHVVSPTAPH

Gene
JBP1
Protein
Thymine dioxygenase JBP1
Organism
Crithidia fasciculata
Length
811 amino acids
Function
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions (By similarity).
Similarity
Belongs to the TET family. JBP1 subfamily.
Mass
90.444 kDa
Sequence
MEPKSKKVKQDIFNFPDGKDVPTTKEKAEAYVDALKAHPFYDNVHSVVDVYDSATLRDGKGRVIGVMLRKALPEHATTAASGLLSAAAVRTSLRSSMFGGESPLSGIAGYFDYRGSPVELKARKTAFTYEHEKKWPAVFPLVDYVSEIYKSVMPEHWAAQDSAIPDIVRIHGTPFSTLTINSRFRTASHTDAGDFDGGYSCIACIDGDFKGLALGFDDFHVNVPMQPRDVLVFDSHYFHSNSELEISCPTEEWRRLTCVFYYRSALGEPSSYAEYRRRLAAAQQDSTAQPVVSSVVEKPNGKNLYKPSTVFPIDPTPFAVVAQLHRLHHCAAKGLCVHELLAVPSSPLAVLLFGERLSCSDGIPLRAAEQKLKANADGASRGVTSSGGFSESDAVLTTAVEKSKYLERDHLSQCISAELLAMWVEARKHWLRLVATEWARMIATAPERTDFLWKNKSPMNTAFFDLCEVAKQVMLGLLDKETATPTEERHFWSVYAAHLHRACAERLMMPEEAMSLRKLNVKLKDFSFGGTRYFKDMPVEEQERRVARKASIEEARRRSTAAKDGEQRSNWLTNDAFDYQTEDCEVDYAGHGWAVPKQHAKTVTANVHQEAVAATTEAVRVLVVLPRPPSGDRGDAAVDLPKEVTTSAEWVRLMSSPAVRRVLAAKQRNLTLLPNCNVEAVSLNFAYHDSLPQKATFDFVVLQHVLSAMPEDAIATDYVSRMRSICTGCLFVVETDVQCRQYFTLHYPLRVQYDAVAPAFFQLLHRCSYGTPLARTRTKAEVEALFPFVCCARYKLQGSPMNTVVHLLALE