JADE1

Protein Jade-1

842 amino acids

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.

Belongs to the JADE family.

95.533 kDa

MKRGRLPSSSEDSDDNGSLSTTWSQNSRSQHRRSSCSRHEDRKPSEVFRTDLITAMKLHDSYQLNPDEYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIVSSGSEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHSSHRKPEESLGKGAAQENGAPECSPRNPLEPFASLEQNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQERVSGVPSSCSSSSLENMLLFNSPSVGPDAPKIEDLKWHSAFFRKQMGTSLVHSLKKPHKRDPLQNSPGSEGKTLLKQPDLCGRREGMVVPESFLGLEKTFAEARLISAQQKNGVVMPDHGKRRDNRFHCDLIKGDLKDKSFKQSHKPLRSTDVSQRHLDNTRAATSPGVGQSAPGTRKEIVPKCNGSLIKVNYNQTAVKVPTTPASPVKNWGGFRIPKKGERQQQGEAHDGACHQHSDYPYLGLGRVPAKERAKSKLKSDNENDGYVPDVEMSDSESEASEKKCIHTSSTISRRTDIIRRSILAS

Jade1

Protein Jade-1

834 amino acids

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (By similarity).

Belongs to the JADE family.

93.897 kDa

MKRGRLPSSSEDSDDNGSLSTTWSQHSRSQHGRSSTCSRPEDRKPSEVFRTDLITAMKLHDSYQLNPDDYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIASSGSEPPALGYVDIRTLADSVCRYDLNDMDAAWLEVTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHSSHRKPEEGLGEGAAQENGAPESSPQSPLEPYGSLEPNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKINFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFTQYTKLLEQEKVSGVPSSCSSALENMLFFNSPSVGPNAPKIEDLKWHSAFFRKQMGTSLVHPLKKSHKRDAVQNSSGTEGKTSHKQPGLCGRREGLEVSESLLSLEKTFAEARLLSSAQQKNGVVTPDHGKRRDNRFHCDLVKGDLKDKSFKQSHKPLRSTDTSQRHLDNTRAATSPGVGQSAPGTRKEIVPKCNGSLVKVPITPASPVKSWGGFRIPKKGERQQQGEAHDGACHQHSDCSHLGVSRAPAKERAKSRLRADSENDGYAPDGEMSDSESEASEKKCIHASSTISRRTDIIRRSILAS

jade1

Protein Jade-1

829 amino acids

Transcriptional coactivator which seems to act by promoting acetylation of nucleosomal histone H4 by kat5. Promotes apoptosis (By similarity).

Belongs to the JADE family.

94.548 kDa

MKRSRVPSTSEDSDNGSNSTSWSQHSNSKHRKQSGKRPSEVFRTDLITAMKLHDSHQLNPEDYYELADPWRQEWEKGVQVPVSPESIPQCAVRTVAEKSTAPLFIKPKKLIRSSESSMLGYVGIQTLADGMCRYDLNEEDVAWLQITNEEFSKMGMQPLDELTMERVMEEFERRCYDNMSHAMETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGIFPKCHLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGNPEKMEPITNVSHIPSNRWALICCLCKEKTGACIQCSAKSCRVAFHVTCGLHCGLKMNTILTEADEVKFKSFCPKHSGLDWNEEEGDDDRPVKVPTREDRSRNRGIDFSASSQTRLSQNPEETRLSERKLRVQQLEDEFYRFVAADEVAEHLQLPLEMVDILFQYWKLKRKVNFNQPLIMPKKEEEDSLARREQEVLLRRLRLFTHLRQDLERVRNLTYMVSRRERIKRTLCRVQEQIFHHHVRLLEQGRVTGVSSTRRLEEAMFYFRTTPPVPASPQPLKGHCGQNSTLSSSEKGSNSYRSSKHIEADKPAKMLMDGVPSSGDSVRSETVMSASSRRSEGRTRSGESHRKEEESERPLEDRRRKSKLWDQVSIKDKLRHAKSMEDTLSSETELDTMDDRLLLSHTNANSVATAPNMYSGSPRKTNASHQGKLVPNGTSGRHLKNWGSFRIPKRSERTSAGRQTERQEADNTADQNSSLKTFSTSPSSPQIRTRLRTGSENRRHLEESDLGQSEQGKRCHTQRLPSPMTRRYGSDVIQRGVLAS

jade1

Protein Jade-1

827 amino acids

Transcriptional coactivator which seems to act by promoting acetylation of nucleosomal histone H4 by kat5. Promotes apoptosis (By similarity).

Belongs to the JADE family.

94.392 kDa

MKRVCLPSSSEDSDDNGSLSTSWSQHSRSLPSFRHEDRKPSEVFRTDLITAMKLHDSNQLNPEDYYVLADPWRQEWEKGVQVPVNPEFIPETIARVIAEKDKVVTFTRPRKYIHSSGSEPPEVGYVDIQTLADAVCRYDLNEMDVAWLQLINEEFKEMGMQQLDEYTMEQVLEEFEKKCYDKMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSNRWALLCSLCNEKVGACIQCSIKNCRTAFHVTCAFDHGLEMKTILTQEDEVKFKSYCPKHGSTKKPEDSHFCRSASDGKDTCEASPTFLGGLRVLEASQQNVKHGSQRKLKLQQLEDDFYSFVDVHDISQALKIPLDVTEYIYQYWKLRRKANFNEPLITPKKDEEDNLAKKEQDVLIRRLQLFTHLRQDLERVRNLTYMVTRREKMKRSVCRVQEQIFNLYTKISEQEKDLGFPLENGLLFNTQPSNPDAPKIEDLKWHSAFFRKRLGSSLRCSMKDSHKKSRERIIGKSLDTEILLTDRKKEGQTSDVSFPLEKTVAKIKPVQQKNGGSFPEHRKRRDSRTQGDTKFDSKEKPLRQQHRPAKHTEPPERPAEKKRALSQCGGKSATASSNKKQCSSSLPRYSGSLIKIHCNRPSVKVPTSPIKNWGGFRIPKKGEKVQPGSMETCQPNLNCQFLGQVSKKGRTKEKVKLDNDNDGYTPDAEMSDSESEPTDKCRLQRLTSSSSLSRGYETDFIRRSILAS

JADE1

Protein Jade-1

509 amino acids

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (By similarity).

Belongs to the JADE family.

58.312 kDa

MKRGRLPSSSEDSDDNGSLSTTWSQNSRSQHRRSSCSRPEDRKPSEVFRTDLITAMKLHDSYQLNPDEYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIVSSGSEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEYVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHSSHRKAEEGLGEGTAQENGAPECSPRDPLEPFAGLEQNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVMTDTDTL