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Itgb6

Gene
ITGB6
Protein
Integrin beta-6
Organism
Sus scrofa
Length
788 amino acids
Function
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity).
Similarity
Belongs to the integrin beta chain family.
Mass
85.972 kDa
Sequence
MGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCSQENFTYLSGVGERCDTPANLLAKGCQLNFIENPLSQVEILTNKPLSIGRQKNSSSIVQIAPQSLTLKLRPGSEQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSLLSKEMSKLTSNFRLGFGSFVEKPISPFMKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGVLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNGTPFPHQKKCSHMKVGDTASFNMTVGIPNCEKRSRHVIVKPVGLGDALEILISPECSCDCQKEVEVNSSKCNHGNGSFQCGVCACNPGHMGPHCECGEDTLSMDSCREAPEHLSCSGRGDCYCGQCTCHLSPYGNIYGPYCQCDDFSCVRHKGLLCGDNGDCECGECVCRSGWTGEYCNCTTSTDQCVSEDGVLCSGRGDCVCGKCICTNPGASGLTCERCPTCGDPCNSKRSCIECHLSADGQAREDCVDKCKLAGATISEEEDFSKDSAVSCSLQGENDCLITFLITTDNEGKTIIHSISEKDCPKPPNSPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKQKVDLSMDG
Protein
Integrin beta-6: ITGB6

Gene
ITGB6
Protein
Integrin beta-6
Organism
Bos taurus
Length
788 amino acids
Function
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity).
Similarity
Belongs to the integrin beta chain family.
Mass
85.893 kDa
Sequence
MGIELLCLFFLCLGRNDHVQGGCAVGGAETCEDCLLIGPQCAWCSQENFTHLSGVGERCDTPANLLAKGCQLTFIENPVSQVEILTNKPLSIGRQKNSSDIVQISPQSLALKLRPGLEQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSLLSKEMSKLTSNFRLGFGSFVEKPISPFMKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTILEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGVLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNTGIPVPHQKKCSHMKVGDTASFNVTVSLPNCERRSRHIILKPVGLGDALEILVSPECSCDCQKEVEVNSSKCNNGNGSFQCGVCACHPGHMGHHCECGEDTLSTESCKEAPGRPSCSGRGDCYCGQCVCHLSPYGNIYGPYCQCDNFSCVRHKGLLCGDNGDCDCGECVCRSGWTGEYCNCTTSTDPCVSEDGILCSGRGDCVCGKCICTNPGASGPTCERCPTCGDPCNSKRSCIECYLSADGQAQEECVDKCKLAGATINEEEDFSKDSFVSCSLQGENECLITFLLTTDNEGKTVIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHKEKQKVDLSTDG
Protein
Integrin beta-6: ITGB6

Gene
ITGB6
Protein
Integrin beta-6
Organism
Homo sapiens
Length
788 amino acids
Function
(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260).
Similarity
Belongs to the integrin beta chain family.
Mass
85.936 kDa
Sequence
MGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKQKVDLSTDC
Protein
Integrin beta-6: ITGB6

Gene
Itgb6
Protein
Integrin beta-6
Organism
Mus musculus
Length
787 amino acids
Function
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (PubMed:10025398). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:10025398).
Similarity
Belongs to the integrin beta chain family.
Mass
86.042 kDa
Sequence
MGIELVCLFLLLLGRNDHVQGGCAWGGAESCSDCLLTGPHCAWCSQENFTHLSGAGERCDTPANLLAKGCQLPFIENPVSRIEVLQNKPLSVGRQKNSSDIVQIAPQSLVLKLRPGREQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLAKEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTFGFKHILPLTDDAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDHRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTALCNNGVLFPHQKKCSHMKVGDTASFNVTVSVSNCEKRSRNLIIKPVGLGDTLEILVSAECDCDCQREIETNSSKCHNGNGSFQCGVCTCNPGHMGPHCECGEDMVSTDSCKESPGHPSCSGRGDCYCGQCICHLSPYGSIYGPYCQCDNFSCLRHKGLLCGDNGDCDCGECVCRDGWTGEYCNCTTNRDSCTSEDGVLCSGRGDCVCGKCVCRNPGASGPTCERCPTCGDPCNSKRSCIECYLSADGQAQEECADKCKAIGATISEEDFSKDTSVSCSLQGENECLITFLITTDNEGKTIIHNINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKHKAGLSSDG
Protein
Integrin beta-6: Itgb6

Gene
Itgb6
Protein
Integrin beta-6
Organism
Rattus norvegicus
Length
787 amino acids
Function
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity).
Similarity
Belongs to the integrin beta chain family.
Mass
85.959 kDa
Sequence
MGIELVCLFLLLLGRNDHVQGGCAWSGAETCSDCLLTGPHCAWCSQENFTHLSGAGERCDTPENLLAKGCQLPFIENPVSQVEILQNKPLSVGRQKNSSDIVQIAPQSLVLKLRPGGEQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLAKEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTFGFKHILPLTDDAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDNRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTALCSNGILFPHQKKCSHMKVGDTASFNVSVSITNCEKRSRKLIIKPVGLGDTLEILVSAECDCDCQREVEANSSKCHHGNGSFQCGVCACNPGHMGPRCECGEDMVSTDSCKESPGHPSCSGRGDCYCGQCVCHLSPYGSIYGPYCQCDNFSCLRHKGLLCGDNGDCDCGECVCRDGWTGEYCNCTTSRDACASEDGVLCSGRGDCVCGKCVCRNPGASGPTCERCPTCGDPCNSRRSCIECYLSADGQAQEECEDKCKATGATISEEEFSKDTSVPCSLQGENECLITFLITADNEGKTIIHNISEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKHKVGLSSDG
Protein
Integrin beta-6: Itgb6

Gene
ITGB6
Protein
Integrin beta-6
Organism
Ovis aries
Length
787 amino acids
Function
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity).
Similarity
Belongs to the integrin beta chain family.
Mass
85.746 kDa
Sequence
MGIELLCLFFLFLGRNDHVQGGCAMGGAETCEDCLLIGPQCAWCSQENFTHLSGVGERCDTPANLLAKGCQLTFIENPVSQVEILTNKPLSIGRQKNSSNIVQISPQSLALKLRPGLEQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSLLSKEMSKLTSNFRLGFGSFVEKPISPFMKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTILEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGVLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNSGVPFPHQKKCSHMKVGDTASFNVTVSLPNCERRSRHVILKPVGLGDALEILVSPECSCDCQKEVEVNSSKCSNGNGSFQCGVCACNPGHVGHHCECGEDTLSTESCKEAPELPSCSGRGDCYCGQCVCHLSPYGNIYGPYCQCDNFSCVRHKGLLCGDNGDCDCGECVCRSGWTGEYCNCTTSTDPCVSEDGILCSGRGDCVCGKCICTNPGASGPACERCPTCSDPCNSKRNCIECYLSADGQAQEECVDKCKLAGATINEEEDFSKDSSVSCSLQGENECLITFLLTTDNEGKTVIHSIEKDCPKPPNIPMIMLGVSLAILLIGVALLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHKEKQKVDLSTDG
Protein
Integrin beta-6: ITGB6

Gene
ITGB6
Protein
Integrin beta-6
Organism
Cavia porcellus
Length
577 amino acids
Function
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity).
Similarity
Belongs to the integrin beta chain family.
Mass
62.299 kDa
Fragment
single
Sequence
SASMDDDLNTIKELGSLLSKEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEIANPCSSIPYICLPTFGFKHILPLTNDAERFNEIVKKQKISANIDNPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVMEYPTIGQLIDKVVQNNVLLIFAVTQEQVPLYENYAKLIPGATVGLLHKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFSAVCNNGTLFPHQKKCLHMKVGETASFNVTVSIPNCERKSRHVIIKPVGLGDTLEILVSPECSCDCQKEVEVNSSKCHNGNGSYQCGVCACNPGHMGPHCECGEDTLSTDSCKETPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGDNGDCECGECVCRSGWTGEYCNCTTSTDTCISEDGTLCSGRGDCVCGKCVCTNPGASGPTCERCPTCSDPCNSKRSCIECHLSADGQPGEECVDKCKLAGVTISKEADFSKDSSVSCSLQGENECLITFLISTDNEGKTIIHNISEKDCPKPPNIPMIMLGVSLA
Protein
Integrin beta-6: ITGB6