ICE1

Little elongation complex subunit 1

2266 amino acids

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780).

Belongs to the ICE1 family.

247.891 kDa

MMPGETHSAAPGTAADLSRCQGCASLQQNLNEYVEALITLKQKIINTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKSSLKLYQDTHQEYARVKEECLKSDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNEKELRHIGTQISSDSYGSIDKRKVKLLLKELWLCVNTTHRLPGEGSRCVPEKPAKAITSSRVPGEDGTLPPTQGSPLRTSNVQTCLTKLSMEIKEDFLCQNVEKQSSSGTNCSSDHVFNENGNLEVLVQSHRDGGSTEFVDHDHFFDEDLQAAIDFFKLPPPLLSPVPSPPPMSSPHPGSLPSSFAPETYFGEYTDSSDNDSVQLRNSAECVSEDDTTESQNYFGSLRKNKGSGTWEEKPKSHEAIQALNTWEVNKVTTSGLETFTATLRESSATHSLVGEKHWTTASRSMSDRKRDILHETKTQMEVREMDKSVQTEKTIHKLTRGLCIERLSASPAQEKEAAPGKSELCSSPLGKRPLNELMESEGKTVLSKMMGSPKSEFTKWTRINEITSEPDRITVSGHFHRLSRELEKEKEDTQGFTLGESPESEDDDSGDGMDVAGLDIETSFSSSSTLVALSVGSNPQSSSGLDCGNDTDITTKVFSTEPHHSEHKLQTKTLNTLHLQSEPPECSIGGNNLENSLCALSPELGASNFNDQKSSGIEYTKVVKGLTKIHSLPRSVFMKATKDGQCESQDPRIELTLNKPDFTSLIGSQAALIKSGLGFVKSTSWHHSDLLRKGGEESLRAKSEHEQKTSHQLQKAMPFLQNRGPTPKPDLLRENNNPVEFKTTASVLPNQVSVITKQTRPEKVQSAKLEHLRPHRVEPTLVTENSGNKTGMSTVAKCDGERDDTTQNITEVAAVKSISPEVSASRRKLDFNSPGGSSPVENSDCSTNSRLSFSPENILIQNQDIVREAAVQGDGQKQRQPQATDLDSSGTHGSEMLPATEVTVSGGFSVEETSCGDTGRSGGEALAVANDSTSTPQNANGLWKLKSTTPGGALPECFGTTDTTFSSAFCRKHGETQDTSQSSLPGTLHCYTGIREGGDDTEVESEAFSCSEGSEQQDAPDDSQKNLGDTDAAVAEVRPSLEVGYLTSALQDFNISTFSELDRLSTSEVVMFLESCQLGDYSSGDSVSECSSKGTLSKEMNKELKASEIGEKYRKQPCEEETLGTCEEWIESEEDDYSLKNTSQLTQCSLETLSEVLTKIRQELQTNSEDCNGKDTGSLLLLNVNNNMTTENLKEKSPFRETTGSSSHASEPTPQAAALDTEGSSPISGMPQNENPQSRPEARSDAGRQTDGGEEDLPEPVEPSALCSDSVMEPSIEQSSNCEAETTFQCQIATVTSEVINVLINKDQNLVIEKGDNWTIISGVAVLPHVDQVTLCDIPGDIPISQDQGELEAGCIPVTSAEKSPEASHTGPAFQEAPCGNNLSCPQEDVSSSGQSTNFDKSRLRNRPVKPSIWISSQIYDQNFETQIVASDHTYYNSKLEPSGKNKNRSKISNKDQSNKPVKTSASSRVETHQSEVAQSFSGEKANTKTQRSQTQTILANADTSTPTDCSPDTLSKIRQEVGPPLPPLLAPLIATPPRTSQPLSPLISSSSPSSPASPVGQVSPFRETPVPPAMSPWPEDPRRASPPDPSPSPSAASASERVVPSPLQFCAATPKHALPVPGRLPPCASGHAAVGGPQENSVKILDTMYPELSARARTLNILKGNIQLTRGPPADCKNLPGPASAMIGFKTITSAATAFVKTGSSSGGDCNQDKSRDLGTQQDSSGKRTLSTSTLRSAKRLRLDTGSPEPETRGVTAEGIHKNLPGNLPPAEVATTNEERSCSSPAVSAVSQLPLSPKETVESHDKAIANALKKIAEFSFDLLPVIRSHVYVGNISKKPVMRDQEKEVVYEFSTTKKHLAECLLHSILSELKIQKISMDHNYIHALCRVYVGICRQLGDLERARLFCYSLLKEDFPESEKLTLFIANMWHDIFLSQSVINKAMQLVARQRAKGEVLNCLRAFLNWEKNAPVDVGFMVSKLLLTIQLCPKTEFQPSEKFGEDLSDNTWEYIFAIDLLCCHQKWIWTHDNIISKELWPVMDKWIKYRKGHANIAYTPDIIIASILRLIGRLGQLGLKEGFPSAVKNISSVIGMFIQHAHDEDIPWGIQLAAVYALCDLSPSNPAEISKILEAWRREASKSVPSAIVSCLEEVSALSTEELG

Ice1

Little elongation complex subunit 1

2241 amino acids

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (By similarity).

Belongs to the ICE1 family.

242.254 kDa

MMPGETHPAAPGPADLARCQGCASLQQNLNEYVEALIALKQKIINTDNLLTEYQKKCDELQFARRENSTLHHQVEQMLQKISPLQKCQEELGSLKAELEEKKSSLKLYQDTHQEYARVKEECLRTDAQKKKLEAKVKKLEEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNEKELRHIGTQISSDSHGSIDKRKVKVLLKELWLCVNTAHRLSGEGGRRIPEKPAKGSSAARASEQDELLPVQGGPARAADMRSFFSKLSMEMEGDFSSSESAEEELPSGASPSTEHAFCEERHSEVSGQRPDDGNRTNVYDHEHFFDDDLQAAIDFFKLPPPLLSPVPSPPPMASGSLPSSLAPESFFGEFTDSSDSDSVPPRDSMESALEDYTAESRAYFDLLEKIKRSDQYVKKPGSLEATQAVNSLTPLGFVTGRTALGEPSAAASLAQGRHWTESSEFVRDRGDSVEEAERMVEAREVDKSVQVGKGLLKHNRKLWLEMASRGPARKKEAGAGESEICFSSLGKRTFSELIESEGKTLSSKALCPSQSEFSKRTLTDGSASKSPCVTGSGRFQRRERDVRESTPQSGICAAAAGRGHSARLPSSSSATSVPVSVCSNHQTPWPGCVSVGTPAEGTCTEQKSPTRTLNTFLLRSEPTACFPKENDPENSLSTLSPKSKLGTSTFSDWKSRGLESFSTLKSTAKGHSLPQSVFPKPTGGGQCKGRGPGATLILPKSDWTSLARSQAGFTRRSSGSADSTSWHRSDVLRRGSGGSPRASSEYQQRTRLQLEKATPASQNSSLTAMHGPSGESTIPPESNAAAALLPNQVSVITKQARPRRVLGSSLEPWQPHGNTLSPAVNGGKETGLMPSVSACVGDGDPIAQVPEQIADKETPSPEVSVSWRNPICDSPSDSLLAENFSCSTDRKLPFSSEDNIFQCAMNEHLQQKPTKSPQTTQSGASRLEAGELLPSGVTSGVFPAEQVPHGPHHQADTEAPVVARESHSAPQNASAPPVVPSRGPLRARVPTVPVCPSSLSRAEEETQGTSQSSLPGASYCYTGIRERGEEDTEVEDEAVSCSEGEHEAEAVMGRRQQEQAEDSHRPLGDPEAGVGEAGHPSDVGDLTSALEECNLSTLLYIDKLSTSEVVMVLESCQLGDYSSRVSASECASKGSLSEEMNTELRQSEISRKKCGKRLWEEKLLRASEEWAESEGDDSCGRTSCQHAQCPLEVPSDVLTKTGEELDTNPVDCGGTDTEHALLESTHHSQAAEDLTEDALPEETSSPMPHTAELPDPSAVDGGGSSPLSSRSDPEHIQSSYEDEPNSGECLSIGEEGLAEPGELLTLSSDSSTPPRLEQSSDCVAETAFRYQISAVTSEVISVLINKDQDLVIEKGDNWTIISGVAISPGMEQVVLCDTLGDAASSQDQGGLDDGSMEKSPEASPSGPLPQEPPCGGDLSGAQEDISSNGQSANFDKSRLRNRPVKPSIWIRSQIYDQTLETEKVASDHTYYNWKLEPLGKNKPRSKISNKDQASKLAKTLVLNRGEVHLNEVPQPASGEGTNIKLPRSQAQPIMAGTDRSTPTNCSPDTLSKIRQEVGPPLPPLLPPLIATPPRSSQTLSPLVPNSGPSSRSSPAGHVSPLCEVPGPPVLSPWPEELQQASPLDPSPSPSTAAASGRIVSSPLQFCAATPKHALPVPGRLPSCAPGHAAVSGPQQENSVKILDTMYPELSARARTLSLLKGNMQLSRGSTVDGKVLPGRVSALLGLKAITSTSTAFVLTGGSSGADGSQGKSQDSGVQQDAGGKRTLAVSMLRSAKRLRLDNKSPEPDTREVTGEGVPEDPQGGSPLAEVVPAEEEQADVPVCSAASLLRVNPREMAESYNIAITRALRKIAESSFDLLPVIRSHVYVGNISKKPVMRDQEKEVVYEFSTTNKHLGEYLLRSILSELKIQKTSLDHSYIHALCRVYVGICRQLGDLERARLFCYSLLKEDFPESEKLTLFIANMWREVFLSQSAISEAMQLVARQRARGEVLNCLRAFLSWEKNAPIDVGIVVSKLLLTIQLCPKTEFQSSEEFGEDLSANIWEYIFAIDLLCCHQRWIWTHDNIISKELWPVMDKWIKYRKGHSNIAYTPDVIVASVLRLIGRLGQLGLKEGFPTAVKNISSVIGMFIQHAQDEDIPWGVQLAAVYALCDLSPSNPAEISKILEAWRTQTSNAIPSAIVHCLEEVGSLSADGSAGCTSKGDSAP

Ice1

Little elongation complex subunit 1

1395 amino acids

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780).

Belongs to the ICE1 family.

157.467 kDa

MNLDEFSDFNIDQLLGPSAPLQDALVAPYKQVSLPRSNQDVYAKRSRLAERIAQNDELIRQVKQLQAQNKQLADLQRTAQEVTDLYQKEKQQRIELEKRTKQIGERCGQLEKELDVQVGNCENLQEQLQVRGLPVEAKDVLSILMQFSQRLGDDCGLLRRDQNIMKKLREHCKTIDVSVPTPKSPNSRSKRKAHQPGVNQSTQTDEEPADPKPALCSVAVQVEGLIETRNQATQHKNTTTTRGTTTASFIKHHDVGTCFPEPKPLPNIRQILDEMLSWRDDVVIEPMSPLSDLQQELQLEDVPTNASVATCTTLCDIHREIDFVTDLPTQIKVSASRPPSRTMLDSVKEEARSSRELAKELFNFLPQNQSCLTNLPPQAFEELWQVFGQMVLALLQRRSNPSMATPPSVSQADFTRWLYELYEGTENQTEQTSNGSTSKRDFATSTECMDTGTDPIIQSPNISHEGHVTPIRLPSKPKERKRKSKKRKAAATPKPIAKRKCLEMETNNELEVEREQTPETAIQFLSNLETFNMANCDNLEMELDEEELYLLQLTSNAKQNENKGNVRVQDPDDLKSPAQTSKFPKSENHLPAVLKETASSLKGYDEKQCPFPDKTEELMHKKTFEIQENIGSLTELPPNIDISAYPVSMAEVRIVSSNKPSEMEVNASEGTDSHLDKSVSNLDTGSMSLFGSDSDVESEYSIEQMAPELSDSDDTFDNSEEDCRSADEPSNSKKIRNSSLFGSESESDESEERALEADDLTEAEAKVEEKESEQKSSDVAPAASSGKLLVVEADLVTKTQPLFVEKLDLENTQHTSTCTNPKETDESEDEHGLVIDEQIFISQPEEPPLTVPIAAKRRRTQSELKTLSPPGEVRLTRQRAKQLLDEQKSGPEKGLSLVEQIRRQLKKAINKSEPFKKDSTHDSKKDSTHDLKPLEHEDELKAMQLGTNFEPIKLSCSISEESPASPPACEPMDELDPPPIEIPLEQAACTRKDDQHKSIVQHVLKMDTGLEKLVEANRKTLGKSQPQLCASIGKYLQENMQLESTCSDLAMDIYKVTKSEAVIVNAMITVICKIGLDDGPVERLLNALKYLNFSQRFLAELEERLFRNTKERPATELALNYVRLYLKATALQATMSAGYENPARLLLAKILYHFDQDMPPLVMEVLRQFPTALPHREQREYDNSDALITVIKHLLMNRQYDMQDPNGAERLLLSKLRFEYHFQPYEPSKQQVLENLVGKLKAGREEELGYAFALFCRRSPHLKVVESVVGEHLMPLATSYCDLAAQNELYDARLGLLLHCISLVLKPLPLDTDISAFVGFLKRLLVAVPRSGVQLAAVKASLRLQRFGFKYTLDALKDYRPNYELDPLTRAMIRCFAKRRRHFRHVAATGRRTEI