Function
Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood (By similarity).
Similarity
Belongs to the integrin alpha chain family.
Sequence
MVFKTIWIERYRKLINLFRALASCHGSNLDVEKPVVFKEDAASFGQTVVQFGGSRLVVGAPLEAVAVNQTGQLYDCAPATGVCQPILLHIPLEAVNMSLGLSLVADTNNSQLLACGPTAQRACAKNMYAKGSCLLLGSSLQFIQAIPATMPECPGQEMDIAFLIDGSGSIDQSDFTQMKDFVKALMGQLASTSTSFSLMQYSNILKTHFTFTEFKSSLSPQSLVDAIVQLQGLTYTASGIQKVVKELFHSKNGARKSAKKILIVITDGQKFRDPLEYRHVIPEAEKAGIIRYAIGVGDAFREPTALQELNTIGSAPSQDHVFKVGNFVALRSIQRQIQEKIFAIEGTESRSSSSFQHEMSQEGFSSALSMDGPVLGAVGSFSWSGGAFLYPSNMRSTFINMSQENEDMRDAYLGYSTALAFWKGVHSLILGAPRHQHTGKVVIFTQESRHWRPKSEVRGTQIGSYFGASLCSVDMDRDGSTDLVLIGVPHYYEHTRGGQVSVCPMPGVRSRWHCGTTLHGEQGHPWGRFGAALTVLGDVNGDSLADVAIGAPGEEENRGAVYIFHGASRQDIAPSPSQRVTGSQLFLRLQYFGQSLSGGQDLTQDGLVDLAVGAQGHVLLLRSLPLLKVGISIRFAPSEVAKTVYQCWGRTPTVLEAGEATVCLTVRKGSPDLLGDVQSSVRYDLALDPGRLISRAIFDETKNCTLTRRKTLGLGDHCETMKLLLPDCVEDAVTPIILRLNLSLAGDSAPSRNLRPVLAVGSQDHVTASFPFEKNCKQELLCEGNLGVSFNFSGLQVLEVGSSPELTVTVTVWNEGEDSYGTLIKFYYPAELSYRRVTRAQQPHPYPLRLACEAEPTGQESLRSSSCSINHPIFREGAKATFMITFDVSYKAFLGDRLLLRASASSENNKPETSKTAFQLELPVKYTVYTVISRQEDSTKHFNFSSSHGERQKEAEHRYRVNNLSPLTLAISVNFWVPILLNGVAVWDVTLRSPAQGVSCVSQREPPQHSDLLTQIQGRSVLDCAIADCLHLRCDIPSLGTLDELDFILKGNLSFGWISQTLQKKVLLLSEAEITFNTSVYSQLPGQEAFLRAQVSTMLEEYVVYEPVFLMVFSSVGGLLLLALITVALYKLGFFKRQYKEMLDLPSADPDPAGQADSNHETPPHLTS