About Products Protein Database Contact

ISS1

Gene
ISS1
Protein
Aromatic aminotransferase ISS1
Organism
Arabidopsis thaliana
Length
394 amino acids
Function
Coordinates and prevents auxin (IAA) and ethylene biosynthesis, thus regulating auxin homeostasis in young seedlings (PubMed:23377040, PubMed:26163189). Shows aminotransferase activity with methionine; can use the ethylene biosynthetic intermediate L-methionine (L-Met) as an amino donor and the auxin biosynthetic intermediate, indole-3-pyruvic acid (3-IPA) as an amino acceptor to produce L-tryptophan (L-Trp) and 2-oxo-4-methylthiobutyric acid (KMBA) (PubMed:23377040). Can also use tryptophan (Trp), phenylalanine (Phe), and tyrosine (Tyr) as substrates. Regulates tryptophan (Trp) homeostasis and catabolism in mature plants. Also possibly involved in the metabolism of other aromatic amino acids and phenylpropanoid homeostasis (PubMed:26163189).
Similarity
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Mass
43.762 kDa
Sequence
MGSFGMLSRRTLGTDMPVMAQIRSLMAELTNPMSLAQGVVHWQPPQKALEKVKELVWDPIISSYGPDEGLPELRQALLKKLREENKLTNSQVMVTAGANQAFVNLVITLCDAGDSVVMFEPYYFNSYMAFQMTGVTNIIVGPGQSDTLYPDADWLERTLSESKPTPKVVTVVNPGNPSGTYVPEPLLKRIAQICKDAGCWLIVDNTYEYFMYDGLKHCCVEGDHIVNVFSFSKTYGMMGWRLGYIAYSERLDGFATELVKIQDNIPICAAIISQRLAVYALEEGSGWITERVKSLVKNRDIVKEALEPLGKENVKGGEGAIYLWAKLPEGHRDDFKVVRWLAHRHGVVVIPGCASGSPGYLRVSFGGLQEVEMRAAAARLRKGIEELLHHGMVE