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IRX3

Gene
Irx3
Protein
Iroquois-class homeodomain protein IRX-3
Organism
Mus musculus
Length
507 amino acids
Function
Transcription factor involved in SHH-dependent neural patterning (PubMed:10830170, PubMed:15201216). Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube (PubMed:10830170, PubMed:15201216). Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals (PubMed:10830170, PubMed:15201216). Involved in the transcriptional repression of MNX1 in non-motor neuron cells (PubMed:15201216). Acts as a regulator of energy metabolism (PubMed:24646999).
Similarity
Belongs to the TALE/IRO homeobox family.
Mass
52.693 kDa
Sequence
MSFPQLGYQYIRPLYPPERPGAAGGGGGGSSAGGRSGPGAGASELAASGSLSNVLSSVYGAPYAAAAAAAAAAQGYGAFLPYATELPIFPQLGAQYELKDSPGVQHPATAAAFPHPHPAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEESKRELEMEEEELAGEEEDTGGEGLADDDEDEEIDLENLDSAAAGSELTLAGAAHRNGDFGLGPISDCKTSDSDDSSEGLEDRPLSVLSLAPPPPPVARAPASPPSPPSSLDPCAPAPAPSSALQKPKIWSLAETATSPDNPRRSPPGAGGSPPGAAVAPPTLQLSPAAAAAAAAAHRLVSAPLGKFPAWTNRPFPGPPAGPRPHPLSMLGSAPQHLLGLPGAAGHPAAAAAAYARPAEPESGTDRCSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS

Gene
IRX3
Protein
Iroquois-class homeodomain protein IRX-3
Organism
Homo sapiens
Length
501 amino acids
Function
Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism.
Similarity
Belongs to the TALE/IRO homeobox family.
Mass
52.119 kDa
Sequence
MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAPYAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSEDSSEGLEDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAETATSPDNPRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFPGPPPGPRLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS

Gene
irx3
Protein
Iroquois-class homeodomain protein irx-3
Organism
Xenopus laevis
Length
448 amino acids
Function
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Both up-regulates and down-regulates gene expression during neural development. Acts early in neural plate development to induce proneural gene expression and specify a neural precursor state. Also up-regulates repressors that prevent neuronal differentiation. Required during at least two stages of pronephros kidney development; during neurula stages, maintains transcription of key renal genes to define the size and identity of the pronephric anlage, probably in part through regulation of bmp-signaling. Subsequently required for proper formation of the intermediate tubule segment of the pronephros.
Similarity
Belongs to the TALE/IRO homeobox family.
Mass
49.312 kDa
Sequence
MSFPQLGYQYIRPLYPSDRQSVGVTRSGTELSPAGTLSNVLSSVYGAPYAAAAAAQAYGAFLPYSAELPIFPQLGSQYDMKDSPGVQHAAFSHPHPAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSDHEEDKHEDEEEIDLENIDTEDIESKEDLDDPDTDIHSDSKTDTRSDSEVSDGFEDLNVPEDRLLKSVVGQRQLLNEEPQDKCALSSDAKVPQPACEQIKLNRLPPSPPQENNMPVAHKPKIWSLAETATTPDNPRNSPNTGGSVNTQNLIAQHRLIASPGSRFQGWTGRAFSAQQLSLLNSAHFLQGLGVSHTAPCSGNASFPKAAESKCSTNSLTDRPSTVDIEKTIPVLNTAFQPVQRRSQNHLDAAMILSALSSS

Gene
irx3
Protein
Iroquois-class homeodomain protein irx-3
Organism
Xenopus tropicalis
Length
448 amino acids
Function
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Both up-regulates and down-regulates gene expression during neural development. Acts early in neural plate development to induce proneural gene expression and specify a neural precursor state. Also up-regulates repressors that prevent neuronal differentiation. Required during at least two stages of pronephros kidney development; during neurula stages, maintains transcription of key renal genes to define the size and identity of the pronephric anlage, probably in part through regulation of bmp-signaling. Subsequently required for proper formation of the intermediate tubule segment of the pronephros.
Similarity
Belongs to the TALE/IRO homeobox family.
Mass
49.174 kDa
Sequence
MSFPQLGYQYIRPLYPSDRQNVGGTRSGTELSPAGTLSNVLSSVYGTPYAAAAAAQAYGAFLPYSAELPIFPQLGSQYEMKDSPGVQHAAFSHPHAAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSDHEEDKHEDDEEIDLENIDTEDIESKEDLDDPDTDIHSDSKTDARSDSEASDGFEDLNAPEDRLLKSVVGQRQVLNEEPQDKCALSSDAKASQPACEQIKLDRIPSSPPLENNIPAAHKPKIWSLAETATTPDNPRRSPNTGGSVNTQNLIAQHRLIASPGSRFQGWTGRAFSAQQLSLLNSAHFLQGLSVSHTALGSGTASFPKAAEPKHSTDSLTDRSSTVDIEKKIPVLNTAFQPVQRRSQNQLDAAMILSALSSS