Il12rb2

Interleukin-12 receptor subunit beta-2

874 amino acids

Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. Can also activate STAT3.

Belongs to the type I cytokine receptor family. Type 2 subfamily.

98.197 kDa

MAQTVRECSLALLFLFMWLLIKANIDVCKLGTVTVQPAPVIPLGSAANISCSLNPKQGCSHYPSSNELILLKFVNDVLVENLHGKKVHDHTGHSSTFQVTNLSLGMTLFVCKLNCSNSQKKPPVPVCGVEISVGVAPEPPQNISCVQEGENGTVACSWNSGKVTYLKTNYTLQLSGPNNLTCQKQCFSDNRQNCNRLDLGINLSPDLAESRFIVRVTAINDLGNSSSLPHTFTFLDIVIPLPPWDIRINFLNASGSRGTLQWEDEGQVVLNQLRYQPLNSTSWNMVNATNAKGKYDLRDLRPFTEYEFQISSKLHLSGGSWSNWSESLRTRTPEEEPVGILDIWYMKQDIDYDRQQISLFWKSLNPSEARGKILHYQVTLQEVTKKTTLQNTTRHTSWTRVIPRTGAWTASVSAANSKGASAPTHINIVDLCGTGLLAPHQVSAKSENMDNILVTWQPPKKADSAVREYIVEWRALQPGSITKFPPHWLRIPPDNMSALISENIKPYICYEIRVHALSESQGGCSSIRGDSKHKAPVSGPHITAITEKKERLFISWTHIPFPEQRGCILHYRIYWKERDSTAQPELCEIQYRRSQNSHPISSLQPRVTYVLWMTAVTAAGESPQGNEREFCPQGKANWKAFVISSICIAIITVGTFSIRYFRQKAFTLLSTLKPQWYSRTIPDPANSTWVKKYPILEEKIQLPTDNLLMAWPTPEEPEPLIIHEVLYHMIPVVRQPYYFKRGQGFQGYSTSKQDAMYIANPQATGTLTAETRQLVNLYKVLESRDPDSKLANLTSPLTVTPVNYLPSHEGYLPSNIEDLSPHEADPTDSFDLEHQHISLSIFASSSLRPLIFGGERLTLDRLKMGYDSLMSNEA

IL12RB2

Interleukin-12 receptor subunit beta-2

862 amino acids

Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.

Belongs to the type I cytokine receptor family. Type 2 subfamily.

97.135 kDa

MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIRVYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKYPIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLVDLYKVLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLKMRCDSLML

IL12RB2

Interleukin-12 receptor subunit beta-2

861 amino acids

Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. On IL12 stimulation, enhances IFN-gamma expression.

Belongs to the type I cytokine receptor family. Type 2 subfamily.

96.208 kDa

MAHTVGGCSLALIFIIMLLLVKAKIDVCKRGDVTVQPSHVISLGSAVNISCSLKPKQGCLPSSSFNKLILYKFDRRIYVQHGHSLSSQVKGLPLGTTLFVCKLACSSSDEIRICGAEISVGVVPEQPRNLSCIQKGERGTVTCTWHRGRDTHLYTAYTLQLNGPKNLTWQKQCNDHYCDHLDLGINLTPESLESSYTVKVTAINSLGSASSFPFSFTLLDIVRPLPPWDIRIKFVNASVDRCTLLWRDEGLVLLNRLRYRPINSRSWNMVNVTNAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRTQTPEEEPIGMLNVWYMRQHIDYNRQQISLFWKNLSLSEARGKILHYQVTLQKVAGGEITLQNITEHTSWTWVIPRTGNWAAAVSAANSKGSSLPTRINITDLCGAELLAPQQVLAKSEGMDKLMVTWTPPEKATAAVQEYVVEWRELHPGAGMQPPLGWLWSPPYRLSALISENIKPYICYEIRVHALAGDQGGCNSTRGNSQHKAPLSGPHINAISEEKGSVLISWDEIPAREQMGCILHYRIYWKERDSNSQPQLCEIPYRISPNSHPIDSLQPRVTYVLWMTALTAAGESPQGNEREFCLQGKANWSTFVAPSICMAVIMVGVLSMRCFRQKVFVLLLALRPQWCSKEIPDPANSTWAKKYPIVEEKTQLALDRLLTEWPTPEEPEPLVINEVLCRVTPVFRPPHHRSWSEKGQGVQGHYTSEEDTGYSASSPPPPRAPTAETGQGVDLYKVLGSKGPDSKPGNPASPLTILPVDYLPTHDGYLPSNMDYLPSHEAPITDPLEELPQHISLSIFPSSSLRPLTFSCGEKLTLDQLKMGCGSLML

IL12RB2

Interleukin-12 receptor subunit beta-2

861 amino acids

Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway.

Belongs to the type I cytokine receptor family. Type 2 subfamily.

96.056 kDa

MARTVCGCSWALIFIIMSLLVKAKIDVCKRGDVTVQPSHVISLGSAVNISCSLKPRQGCLQVSSLNKLILYRFHRRIHFQRGHSLSSQVTGLPLGTTLFVCKLACSSKEEIRICGAEISVGVVPEQPQNVSCMQKGERGTVACSWDRGRDTHLYTAYTLQLNGPKNLTWQKQCSDYYCDSLDLGINLPPESPESSYTAQVTAINSLGTASSLPSTFTFLDVVRPLPPWDIRIKCVNASVSTCTLQWRDEGLVLLNRLRYRPVYSRSWNMVNATNAKGRHDLVDLKPFTEYEFQISSKPHLQKGRWSDWSESLRTQTPEKEPTGMLDVWYMKQHIDYKRQQISLFWKNLSLSEARGKILHYQVTLQEVAEGNATLQNITERNSWTWTIPRTGIWAAAVSAANSKGSSLPTRINIADLCGAGLLAPQQVSANPEGSDNLLVKWTSPGEGATAVQEYVVEWRELHLRGGMQPPLSWLRSPPYNTSTLISDNIKPYICYEIRVHALSGDQGGCSSIRGDLKHKAPLSGPHINAISEEKGSILISWDEIPAQEQMGCILHYRIYWKERDSDSQPQLCEIPYRVSPKSHPINSLQPRVTYVLWMTALTAAGESPQGNEREFCLQGKANWSTFVAPSICIAVITVGVFSMRCFRQKVFVLLLALRPQWCSREIPDPANSTWAKKYPIVEEKKQLSLDRLLADWPTPEEPEPLVINEVLPQVTPVFRRPHHPNWPGKGQRLQGRHASEEDTGSSASSPPPPRALTAETGPAVDLYKVLGSRRPDSKPGNPVSHLTVLPVDYLPTHEGYLPSNMDYLPSHEAPITDSLEELPQHISLSVFPSNSLHPLTFSCGEKLALDQLKMGCGSLML