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IFT81

Gene
IFT81
Protein
Intraflagellar transport protein 81
Organism
Chlamydomonas reinhardtii
Length
683 amino acids
Function
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis.
Similarity
Belongs to the IFT81 family.
Mass
77.073 kDa
Sequence
MGDVSYIVDSLGLPPFSYQMSLLSFTEKGPQELLQLLSDVFSTISPKHQKVDVAKEVPDQTADRLIGFLKIIKYRPNVQDPLLFRQLVAAGDRETLYQILRWVVPQAQLLEKRAFVGYYLSFPDMPEEFNFDPDIMELKEEIKAMQQEFIELHKSSDAIKTLSKDTQALKNKIKSLEEEKERLGEKVERAKGAVDKLPDRSSYMEVCTNLRKQQDEEVNLSTAIQTQRALQEKAEASYHRAAARLRELQTSYQEGSAGKLLETLNEDVKNLRAQVNERYPKEVEKRQKRQAALSEALASGISTEMDLQRLQHQATALHNQITEIQERKVAQDKARQGDKAYLQLRQAQQMATVSARKKEELGAKQERLQEKKTALTAQLDKLNAEGGGSGAVFSEEEWRTKYESMKSKLPIYKKMKKELGDLEAEVFVLAHTEELLASQEGGLLEKVKRLEKQQGISGFTETAQHLEKVSEAKSQMDEEKGMTLIEISRTVEEINNAINQRKQQLAPQIKKLRSVRQDFAEFEAKYLEKKTAYDNVVATFEARTSALEGEVSGLKAEVSENETKYHMLHCQLHITDQNIKKVTSGPAAERLRDKYEAKVKEAEDSTKALRDRQREIKDTHSTGLSQIDIMNDMLRLLQLKLNLARGIAVDMSQYGGGGGAAGGANGGMAGQTYDTGSANVLQL
Protein
Intraflagellar transport protein 81: IFT81

Gene
IFT81
Protein
Intraflagellar transport protein 81 homolog
Organism
Homo sapiens
Length
676 amino acids
Function
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region (PubMed:23990561). Required for ciliogenesis (PubMed:27666822, PubMed:23990561). Required for proper regulation of SHH signaling (PubMed:27666822).
Similarity
Belongs to the IFT81 family.
Mass
79.746 kDa
Sequence
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGEDRLIL
Protein
Intraflagellar transport protein 81 homolog: IFT81

Gene
Ift81
Protein
Intraflagellar transport protein 81 homolog
Organism
Mus musculus
Length
676 amino acids
Function
Isoform CDV-1R: May play a role in development of the testis and spermatogenesis.
Similarity
Belongs to the IFT81 family.
Mass
79.285 kDa
Sequence
MSDQIKFIVDSLNKEPFKKNYNLITFDSLGPMQLLQVLNDVLAEIDPKQDVDIREEMPEQTAKRMLNLLGILKYKPPGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRSNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKECEQLKTSGFSTAEIRRDISAMEEEKDQLMKRVERLKKRVETVQNHQRMLKIARQLRVEKEREEFLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRHAAADAKPESLMKRLEEEIKFNSYMVTEKFPKELESKKKELHFLQKVVSEPAMGHSDLLELETKVNEVNTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQETKEKLASLEREVLVKTNQTREFDGTEVLKGDEFKRYVSKLRSKSTVFKKKHQIIAEFKAEFGLLQRTEELLKQRQETIQHQLRTIEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLNSLVSEKKSALAPVIKELRQLRQKCQELTQECDEKKAQYDSCAAGLESNRSKLEQEVRGLREECLQEESKYHYTNCMIKNLEVELRRATDEMKAYVSSDQQEKRKAIREQYTKNITEQENLGKKLREKQKAVRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSPASIGQVIQEGGEDRLVL
Protein
Intraflagellar transport protein 81 homolog: Ift81

Gene
Ift81
Protein
Intraflagellar transport protein 81 homolog
Organism
Rattus norvegicus
Length
675 amino acids
Function
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling.
Similarity
Belongs to the IFT81 family.
Mass
79.029 kDa
Sequence
MSDQIKFIVDSLNKEPFKKNYNLITFDSLGPMQLLQVLNDVLAEIDPKQDVDIREETPEQTAKRMLSLLGILKYKPPGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRSSELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKALHKECEQLKTSGFSTAEIRRDISAMEEEKDQLMKRVERLKKRVETVQNHQRMLKIARQLRVEKEREEFLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRHAAADAKPESLMKRLEEEIKFNSYMVTEKFPKELESKKKELHFLQKVVSEPAMGHSDLLELESKVNEVNAEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQETKEKLASLEREVSVKTNQTREFDGTEVLKGDEFKRYVSKLRSKSTVFKKKHQIIAEFKAEFGLLQRTEELLKQRQETIQHQLRTIEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLNSLVSEKKSALAPVIKELRQLRQKCQLTQECDEKRTQYDSCAAGLESNRSKLEQEVRGLREECLQEESKYHYTNCMIKNLEVQLRRATDEMKAYVSSDQQEKRKAIREQYTKNITEQENLGKKLREKQKAVRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSPASIGQVIQEGGEDRLVL
Protein
Intraflagellar transport protein 81 homolog: Ift81