IFT57

Intraflagellar transport protein 57

469 amino acids

Required for the maintenance and formation of cilia.

Belongs to the IFT57 family.

51.309 kDa

MSSKRGGRSSLAKAPEEAVNGEAFAPEASPPPPGDDGDAGGEDGGAPAPPPPPATKGGPVAVGRSLEIQTTPDVCMEMLADKLKLLNYEADFCRKKKPYRKPLSRLYFAVPLANSSEQFFYFTSLATWLLGLAGVELPAPKEFDDPNLTCQNILGAVKKLGFAPPSYHPTKLTVGNGKEVVGVLDGLVDFVLERRHHKYSRPAYGNDGQPEEGVQLDDEAEAAAMEGADELAMPAQNQADDDEEEEGVYVDPGRGDAAGPGTGASAAMDAEKAVLVSKVDPTLWKIELERVAPKLRITIAADSKDWRSHLDEAHQHKEVISKAWPDSKTSLERLRADLNGTLEKLQTREKFLNEQFESLMQQYRAARTTFTDVQETYNRKTEAVADRNQEMHRIGETLEEVKAMMDEKGSNIADATPVARIKTAIKQLNKELHDMEVRIGVVSHTLLQLSLRNKRLLQAQAALSDEEED

IFT57

Intraflagellar transport protein 57 homolog

429 amino acids

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

Belongs to the IFT57 family.

49.108 kDa

MTAALAVVTTSGLEDGVPRSRGEGTGEVVLERGPGAAYHMFVVMEDLVEKLKLLRYEEEFLRKSNLKAPSRHYFALPTNPGEQFYMFCTLAAWLINKAGRPFEQPQEYDDPNATISNILSELRSFGRTADFPPSKLKSGYGEHVCYVLDCFAEEALKYIGFTWKRPIYPVEELEEESVAEDDAELTLNKVDEEFVEEETDNEENFIDLNVLKAQTYHLDMNETAKQEDILESTTDAAEWSLEVERVLPQLKVTIRTDNKDWRIHVDQMHQHRSGIESALKETKGFLDKLHNEITRTLEKISSREKYINNQLENLVQEYRAAQAQLSEAKERYQQGNGGVTERTRLLSEVMEELEKVKQEMEEKGSSMTDGAPLVKIKQSLTKLKQETVEMDIRIGIVEHTLLQSKLKEKSNMTRNMHATVIPEPATGFY

Ift57

Intraflagellar transport protein 57 homolog

429 amino acids

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

Belongs to the IFT57 family.

48.772 kDa

MAAAAAVIPPSGLDDGVSRARGEGAGEAVVERGPGAAYHMFVVMEDLVEKLKLLRYEEELLRKSNLKPPSRHYFALPTNPGEQFYMFCTLAAWLINKTGRAFEQPQEYDDPNATISNILSELRSFGRTADFPPSKLKSGYGEQVCYVLDCLAEEALKYIGFTWKRPSYPVEELEEETVPEDDAELTLSKVDEEFVEEETDNEENFIDLNVLKAQTYRLDTNESAKQEDILESTTDAAEWSLEVERVLPQLKVTIRTDNKDWRIHVDQMHQHKSGIESALKETKGFLDKLHNEISRTLEKIGSREKYINNQLEHLVQEYRGAQAQLSEARERYQQGNGGVTERTRLLSEVTEELEKVKQEMEEKGSSMTDGTPLVKIKQSLTKLKQETVQMDIRIGVVEHTLLQSKLKEKCNMTRDMHAAVTPESAIGFY

IFT57

Intraflagellar transport protein 57 homolog

429 amino acids

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear (By similarity).

Belongs to the IFT57 family.

48.96 kDa

MAAAAAVVTPSGLEDEVSRSRGEGAGEMVVERGPGAAYHMFVVMEDLVEKLKLLRYEENLLRKNNLKPPSRHYFALPTNPGEQFYMFCTLAAWLINKAGRPFEQPQEYDDPNAIISNILSELRSFGRTADFPPSKLKSGYGEHVCYVLDCLAEEALKYIGFTWKRPAYPVEELEEETVAEDDAELTLNKVDEEFVEEETDNEENFIDLNVLKAQTYRLDMNESAKQEDILESTTDAAEWSLEVERVLPQLKVTIRTDNKDWRIHVDQMHQHKSGIESALKETKGFLDRLHNEISRTLEKIGSREKYINNQLEHLVQEYRAAQAQLSEARERYQQGNGGVTERTRILSEVTEELEKVKQEMEEKGSSMTDGAPLVKIKQSLTKLKQETVQMDIRIGVVEHTLLQSKLKEKSNMTRDMHATIIPESAIGSY

ift57

Intraflagellar transport protein 57 homolog

411 amino acids

Required for the formation of cilia. May also have pro-apoptotic function (By similarity).

Belongs to the IFT57 family.

47.274 kDa

MSEDSRRAEDDDRGPGAAYQAFLMMEDLLDKLKLLSYEDEVLRKQNMKPLSRHYFALPTNPGEQFYMFCTLSAWLINKAGNNFDQPQEYDDPNATISNILSQLRSFGYSVDFPPSRLKAGYGEQVCYVLDCFAEEVLKHIRFSWKRPTYPTEEQDEETVVEDDAELTLNKIEDEIAEEDSDNDQEHFIDLKALSAQTQKLNAEESSKPEEILESNTDAAEWILEVERVLPQLKVTIRTDNKDWRVHVDQMHQHRDGIDTSLKETKGYLDKLHNEIAKALEKVSSREKYINNQLEQLVQEYRSAQAQLSEAKERYQQASGGVTERTRILAEITEELEKVKQEMEEKGSSMTDGAPLVKIKQALTKLKHEIVQMDIRTGVVEHTLLQSTLKEKSNMTRDMHALNIPDSSIGAY

ift57

Intraflagellar transport protein 57 homolog

411 amino acids

Required for the formation of cilia. May also have pro-apoptotic function (By similarity).

Belongs to the IFT57 family.

47.357 kDa

MSEDSRRVEDDDRGPGAAYQAFLMMEDLLDKLKLLSYEDEVLRKQNMKPLSRHYFALPTNPGEQFYMFCTLAAWLISKAGHHFDQPQEYDDPNATISNILSELRSFGYSVDFPPSRLKAGYGEQVCYVLDCFAEEVLKHIHFSWKRPTYPTEEQDEENVIEDDAELTLNKIEDEIAEEDSDNDQEHFIDLNALSAQTQKLNTKESSKPEEILESNTDAAEWILEVERVLPQLKVTIRTDNKDWRVHVDQMHQHRDGIDTSLKETKGYLDKLHNEVAKALEKVSSREKYINNQLEQLVQEYRSVQAQLSEAKERYQQASGGVTERTRILAEITEELEKVKQEMEEKGSSMTDGAPLVKIKQALTKLKHEIVQMDIRTGVVEHTLLQSTLKEKSNMTRDMHALNIPESSIGAY

ift57

Intraflagellar transport protein 57 homolog

407 amino acids

Required for the formation of cilia. Essential for differentiation and survival of sensory neurons. May also have pro-apoptotic function.

Belongs to the IFT57 family.

46.593 kDa

MAEEEERGPGSVYQMFVLMEDLLDKLKVLDYEQHVLDKHNIKPLSRHYFVSSPHVLSNPGEQFYMFSVIAAWLITLCGRPFDTPQEYDDPNATVSNILSELRTLGGQVDFPPSKLKTGSGEHVCYVLDQLVEKALKSKGFAWNRPLYPSVEVEDECVQEDDAELTLSKVEEEMTQEDEEYEEEDGLDLDALKTRTNGELSGSRPAVVLESDVDAAEWNLEVERVLPQLKVTIRTDNKDWRIHLDQMHQHQDGINTSLQDAKGCLFKLREDISKTLEKVSSREKYLNTQLEHLISEYRQAQSQLNKVKELYQQASGGVTERTRILAEISEELDKVKQEMEEKGSSMSDGAPVVKIRQSLTKLKQEIEQMDVRMGVVEHTLLQAKLREKNNMTRDMHATHLLEPNAQAY

IFT57

Intraflagellar transport protein 57 homolog

405 amino acids

Required for the formation of cilia.

Belongs to the IFT57 family.

47.173 kDa

MQQDDEQEKSQQLQNFQSDDLLEKLKLLNYEKHLLKEFKLKPLSRFYFVKATNPGEQFYMFTLICWWLCKKLGKDMERPQEYDDPNTVAANIIKLLGEIDVPVDFQPNKLIRGAGPICLSVLEVLSTQACKVAQVGYQKLHIAQEEEFLGDYLEDNAEIILEKLEDEQNAAALSDDSDMELEAHNFRQLNWLNRPQKKSNGDVNLDERNPELDARMSDHQEWHLELERVLPQLKVFVKADARDWRTHISQMETLKTNILENSDTAEAQLKKLHSEFTFDLEKIESREKHLNNELKPLIQQFKELSIELSTIQYAQNQLQEDMEKQTAELNEVMMEQELKKEEMERRGQAMSDGSSVQQIRKAIAKLKDDTAQLNLEVALLVHAHDQDIVVRQLQQNQTTDLANNP