Ifnar1

Interferon alpha/beta receptor 1

590 amino acids

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:1533935, PubMed:14532120, PubMed:23872679). Functions in general as heterodimer with IFNAR2 (By similarity). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:14532120). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (PubMed:23872679). Contributes to modulate the innate immune response to bacterial lipopolysaccharide (PubMed:23872679).

Belongs to the type II cytokine receptor family.

65.796 kDa

MLAVVGAAALVLVAGAPWVLPSAAGGENLKPPENIDVYIIDDNYTLKWSSHGESMGSVTFSAEYRTKDEAKWLKVPECQHTTTTKCEFSLLDTNVYIKTQFRVRAEEGNSTSSWNEVDPFIPFYTAHMSPPEVRLEAEDKAILVHISPPGQDGNMWALEKPSFSYTIRIWQKSSSDKKTINSTYYVEKIPELLPETTYCLEVKAIHPSLKKHSNYSTVQCISTTVANKMPVPGNLQVDAQGKSYVLKWDYIASADVLFRAQWLPGYSKSSSGSRSDKWKPIPTCANVQTTHCVFSQDTVYTGTFFLHVQASEGNHTSFWSEEKFIDSQKHILPPPPVITVTAMSDTLLVYVNCQDSTCDGLNYEIIFWENTSNTKISMEKDGPEFTLKNLQPLTVYCVQARVLFRALLNKTSNFSEKLCEKTRPGSFSTIWIITGLGVVFFSVMVLYALRSVWKYLCHVCFPPLKPPRSIDEFFSEPPSKNLVLLTAEEHTERCFIIENTDTVAVEVKHAPEEDLRKYSSQTSQDSGNYSNEEEESVGTESGQAVLSKAPCGGPCSVPSPPGTLEDGTCFLGNEKYLQSPALRTEPALLC

IFNAR1

Interferon alpha/beta receptor 1

560 amino acids

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:8318540). Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).

Belongs to the type II cytokine receptor family.

63.819 kDa

MLALLGATTLMLVAGRWVLPAASGEANLKPENVEIHIIDDNFFLKWNSSSESVKNVTFSADYQILGTDNWKKLSGCQHITSTKCNFSSVELENVFEKIELRIRAEEGNNTSTWYEVEPFVPFLEAQIGPPDVHLEAEDKAIILSISPPGTKDSIMWAMDRSSFRYSVVIWKNSSSLEERTETVYPEDKIYKLSPEITYCLKVKAELRLQSRVGCYSPVYCINTTERHKVPSPENIQINADNQIYVLKWDYPYENATFQAQWLRAFFKKIPGNHSDKWKQIPNCENVTSTHCVFPREVSSRGIYYVRVRASNGNGTSFWSEEKEFNTEMKTIIFPPVISVKSVTDDSLHVSVGASEESENMSVNQLYPLIYEVIFWENTSNAERKVLEKRTNFIFPDLKPLTVYCVKARALIENDRRNKGSSFSDTVCEKTKPGNTSKTWLIVGTCTALFSIPVVIYVVSVFLRCVKYVFFPSSKPPSSVDEYFSDQPLRNLLLSTSEEQTERCFIIENASIITEIEETDEIDEVHKKYSSQTSQDSGNYSNEDENSGSKISEEFPQQDSV

IFNAR1

Interferon alpha/beta receptor 1

560 amino acids

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).

Belongs to the type II cytokine receptor family.

63.221 kDa

MLGLLGATTLMLVAGAPWVLPAGGADLRSPENVVVSIIDDNFILKWKSSSESVSNVTFSADYQITGMDNWIKLPGCQYVTSTECNFSSIKLKSVYEKTKLRIRAETGNSTSPWYEVEPFIPFQEAQIGPPDVHLEAEDKAIIINLSPPGTKNSVMWAMDSSSFVYSLVIWKNSSSLEERTKTVYARDKIHQLSPETTYCLKVKAGLRSPRKVGVYSPVYCINTTVKHHLPSPENLEINAENRVYVLKWNYTYENVTFQAQWLHAFLKKIPEDHSDKWKQIPNCENVKTTHCVFPQNVFTKGIFFIRVQASNGNSTSLWSEEKRFNTEMQTILFPPVINMKPINDASLRVGIGAPKESEDKSVNQLYPLIYEVIFRENTSDTERDVLEKRTDFTFSNLKPLTVYCVKARALIENDRWNRSSVFSDTVCEKTKPGSTSQAWLIAGILSAILLFPAVFYGVKVVSRCINYVFFPSSKPPSTIDEYFAEQPLKNLLLSTSEEQTEICFIVENTNTITTIEETDQIDDNHSRCSSQTNRDSGVYSNEDENSGSKIGEEILRQAAV

IFNAR1

Interferon alpha/beta receptor 1

560 amino acids

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).

Belongs to the type II cytokine receptor family.

63.918 kDa

MLSLLGATTLMLVAGRWVLPAASGEANLKSENVEIHIIDDNFFLKWNSSSESVRNVTFSADYQILGTDNWKKLPGCQHITSSKCNFSSVELKDVFEKIELRIRAEEGNNTSTWYEVEPFVPFLKAQIGPPDVHLEAEDKAIILSISPPGTEDSIMWALDRSSFRYSVVIWKNSSSLEERTETVYPEDKIYKLSPEITYCLKVKAELRLQSRVGCYSPVYCINTTERHKVPSPENVQINVDNQAYVLKWDYPYESTTFQAQWLRAFLKKIPGKHSNKWKQIPNCENVTTTHCVFPRDIFSMGIYYVRVRASNGNGTSFWSEEKEFNTEVKPIIFPPVISMKSITDDSLHVSVSASEESENMSVNQLYPLVYEVIFWENTSNAERKVLEKRTDFTFPNLKPLTVYCVKARALIENDRWNKGSSYSDTVCEKTKPGNTSKTWLIAGICTALFSILVVIYVVRVFLRCVKYVFFPSSKPPSSVDQYFSDQPLRNLLLSTSEEQTERCFIIENASIITEIEETNEVAEVHEEYNSQASQDSGNYSNEDENSGSKISEEFLQQDSV

IFNAR1

Interferon alpha/beta receptor 1

557 amino acids

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).

Belongs to the type II cytokine receptor family.

63.525 kDa

MMVVLLGATTLVLVAVAPWVLSAAAGGKNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSFTPFRKAQIGPPEVHLEAEDKAIVIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVEERIENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPVHCIKTTVENELPPPENIEVSVQNQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKWKQIPDCENVKTTQCVFPQNVFQKGIYLLRVQASDGNNTSFWSEEIKFDTEIQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTPVIQDYPLIYEIIFWENTSNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSVFSDAVCEKTKPGNTSKIWLIVGICIALFALPFVIYAAKVFLRCINYVFFPSLKPSSSIDEYFSEQPLKNLLLSTSEEQIEKCFIIENISTIATVEETNQTDEDHKKYSSQTSQDSGNYSNEDESESKTSEELQQDFV