About Products Protein Database Contact

ICL1

Gene
ICL1
Protein
Isocitrate lyase
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
560 amino acids
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
62.585 kDa
Sequence
MSPSVRDARNDLASLQQQAAAEAEDIRRWWSQPRWAGTKRVYTAEDIVKRRGTFPVVEYPSSVMADKLVETLARHSRNGTVSQTFGVLDPVQMTQMVKYLDTIYVSGWQCSATASTSNEPGPDLADYPMDTVPNKVEHLFMAQLFHDRKQREARLSCTTQRELDQLGPEIDYLRPIVADADTGHGGLTAVFKLTKMFIERGAAGIHMEDQSSSNKKCGHMAGRCVIPVQEHISRLVTVRMCADVMHSNLVLVARTDSEAATLLSSNIDARDHYYIVGASNPEVTVPLIEVLDAAQQAGASGDRLAQLEEDWCKKAKLRLFHEAFADQVNASPSIKDKAGVIAKFNSQIGPQTGASIREMRKLGRELLGQDVYFDWDLPRAREGLYRYKGGTQCAIMRARAFAPYADLVWFESNFPDFQQAKEFAQGVREKFPNKWMAYNLSPSFNWPKAMPPKEQENYIQRLGEIGYVWQFITLAGLHTNALAIDNFSREFSRFGMRAYAQGIQQREMDEGVDVLKHQKWAGAEYVDSILKLAQGGVSSTASMGKGVTEEQFGSSNGAKL

Gene
ICL1
Protein
Isocitrate lyase 1
Organism
Glycine max
Length
558 amino acids
Function
Involved in storage lipid mobilization during the growth of higher plant seedling.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
62.845 kDa
Fragment
single
Sequence
EAEVAEVQAWWNSERFRLTKRPYTARDVVSLRGNLRQTYASNEMAKKLWRLLKNHQANGTASRTFGALDPVQVTQMAKHLDTIYVSGWQCSATHTTSNEPGPDLADYPYDTVPNKVEHLFFAQQYHDRKQKEERMRMSREERARTPYVDYLRPIIADGDTGFGGTTATVKLCKLFVERGAAGIHIEDQSSVTKKCGHMAGKVLVAISEHINRLVAARLQFDVMGVETVLVARTDAEAANLIQSNIDTRDHQFILGVTNPNLKGKSLATLMQQGMAAGKNGAELQALEDEWLSKAQLKTLSEAVVEAIERQNNIGEEEKRRKLNEWMHHSSYERCLSNEEGREIAEKLGVRNLFWDWDLPRTREGFYRFKGSVTASVVRGCAFSPHADVIWMETASPNVVECTEFSEGVRSKHPQMMLGYNLSPSFNWDASGMSDEQMKDFIPKIAKLGYVWQFITVGGLHSNALITSTFARDFANRGMLAYVERIQREERNNGVDTLAHQKWAGANYYDRYLKTVQGGVASTAAMGKGVTEEQFKESWTRSGAVNIDRGSIVVAKARM

Gene
ICL1
Protein
Isocitrate lyase
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
553 amino acids
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
62.177 kDa
Sequence
MPVPNSEANEFQALQARIDADAKEIEQWWSEPRWNKTKRTYSAREIAIRRGTFPPLTYPSSVMAKKVYKVLEKHHKEGTVSRTFGALDPVQVSQMAKFLDTIYVSGWQCSSTASTSNEPGPDLADYPMDTVPNKVEHLFKAQQFHDRKQWENRAKATSQEELDAMGPAIDYMTPIIADADAGHGGLTAVFKLTKMFIERGAAGIHMEDQTSTNKKCGHMAGRCVIPVQEHINRLVTIRMCADIMHSELVIVARTDSEAATLISSTIDTRDHYFVVGATNPDIEPFAEYMDRAIMAGVSGDELQKLEAAWIEKAGLKLFHEAFADEVNKSSVSNKQEIIKKFNDKVGPLTETSHREAKKLAKELLGKDIFFDWDLPRVREGLYRYRGGTQCSVMRARAFAPYADLVWMESNYPDFEQAREFAEGVKAKYPDQWLAYNLSPSFNWPKAMSVDEQATFIERLGQLGYIWQFITLAGLHTTALAIHKFSEDFAREGMKAYAQNVQQIEMDEGVDVLKHQKWSGAEYIDGLLKLAQGGVSATAAMGQGVTEDQFKSNL

Gene
ICL1
Protein
Isocitrate lyase
Organism
Candida albicans
Length
550 amino acids
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
61.395 kDa
Sequence
MPYTPIDIQKEEADFQKEVAEIKKWWSEPRWRKTKRIYSAEDIAKKRGTLKINHPSSQQADKLFKLLETHDADKTVSFTFGALDPIHVAQMAKYLDSIYVSGWQCSSTASTSNEPSPDLADYPMDTVPNKVEHLWFAQLFHDRKQREERLTLSKEERAKTPYIDFLRPIIADADTGHGGITAIIKLTKMFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPVQEHINRLVAIRASADIFGSNLLAVARTDSEAATLITSTIDHRDHYFIIGATNPEAGDLAALMAEAESKGIYGNELAAIESEWTKKAGLKLFHEAVIDEIKNGNYSNKDALIKKFTDKVNPLSHTSHKEAKKLAKELTGKDIYFNWDVARAREGYYRYQGGTQCAVMRGRAFAPYADLIWMESALPDYAQAKEFADGVKAAVPDQWLAYNLSPSFNWNKAMPADEQETYIKRLGKLGYVWQFITLAGLHTTALAVDDFSNQYSQIGMKAYGQTVQQPEIEKGVEVVKHQKWSGATYIDGLLKMVSGGVTSTAAMGQGVTEDQFKESKAKA

Gene
ICL1
Protein
Isocitrate lyase
Organism
Candida tropicalis
Length
550 amino acids
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
61.577 kDa
Sequence
MAYTKIDINQEEADFQKEVAEIKKWWSEPRWRKTKRIYSAEDIAKKRGTLKIAYPSSQQSDKLFKLLEKHDAEKSVSFTFGALDPIHVAQMAKYLDSIYVSGWQCSSTASTSNEPSPDLADYPMDTVPNKVEHLWFAQLFHDRKQREERLNMTKEERANTPYIDFLRPIIADADTGHGGITAIIKLTKLFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPVQEHINRLVAIRASADIFGSNLLAVARTDSEAATLITSTIDHRDHYFIIGATNPESGDLAALMAEAEAKGIYGDELARIETEWTKKAGLKLFHEAVIDEIKAGNYSNKEALIKKFTDKVNPLSHTSHKEAKKLAKELTGKDIYFNWDVARAREGYYRYQGGTQCAVMRGRAFAPYADLIWMESALPDYNQAKEFADGVKAAVPDQWLAYNLSPSFNWNKAMPADEQETYIKRLGQLGYVWQFITLAGLHTTALAVDDFANQYSQIGMRAYGQTVQQPEIEKGVEVVKHQKWSGANYIDGLLRMVSGGVTSTAAMGAGVTEDQFKETKAKV

Gene
ICL1
Protein
Isocitrate lyase
Organism
Cyberlindnera jadinii
Length
550 amino acids
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
62.394 kDa
Sequence
MPYTPIDIKAEQEAFEREVAAVEQWWKEPRWRKTTRIYTAKDIVQKRGTLQIHYPSSDQAKKLYKLLEEHDRNKTASFTFGALDPIHVTQMAKYLDTVYISGWQSSSTASTSNEPSPDLADYPYDTVPNKCEHLWFAQLFHDRKQHEERFRMTPEERAKTPYTDFLRPIIADADTGHGGITAIIKLTKLFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPIQEHINRLVAIRTAADIFGSDLLCVARTDSEAATLLTSTIDHRDHYFIIGSTNKDLQPLSEVMFQAEQRGLLKVMLAAVEEDWTKKAGLKLFHEAVIDEINSGYYPNKQALIAEFTTKVHPLSNTSNKEARALAKKLTGKDIFFDWEAPRVREGYYRYQGGTQCAVNRARAYAPYADIIWMESKLPDYAQAKEFADGVKAQWPEQWLSYNLSPSFNWNKAMSVLYQETYIQKLAKLGYVWQFITLAGLHTTALAVDNFARDYAKIGMRAYGQQIQAPEIENGVEVVKHQKWSGAEYIDNLLKLVTGGVTSTAAMGKGVTEDQFKDDKSKL

Gene
ICL1
Protein
Isocitrate lyase
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
550 amino acids
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
61.776 kDa
Sequence
MPYTKIDVNEEEKFFQDQVKEIQQWWKEPRWAKTKRIYQAEDIAKKRSSLKVDYPSSNQAKKLYKLLQEHDKNKSASFTFGALDPVQVTQMAKYLDSIYVSGWQCSSTASTSNEPSPDLADYPMDTVPNKVEHLWFAQLFHDRKQREERLNLSKEERAKTPYTDFLRPIIADADTGHGGITAILKLTKLFVERGAAGIHIEDQAPGTKKCGHMAGKVLVPVQEHINRLVAIRASADILGSDLLCVARTDSEAATLLTSTIDHRDHYFVLGATNPESPDLAALMAEAESNGIYGDKLASIEVEWTKKAGLKLFHEAVIDEINNGNFSNKQALIKKFTDKVNPLSATSNKEARKLAREILGKDVFFDWDVARAREGYYRYQGGTQCAVMRGQAYAPYADMIWMESALPDFKQAKEFAEGVKAKWPDQWLAYNLSPSFNWNRAMPPNEQETYIKRLSELGYVWQFITLAGLHTTALAVDDFANQYSQIGMRAYGQTIQAPEIEKGVEVVKHQKWSGAEYIDGLLKMVTGGVSSTAAMGAGVTEDQFKEKAAGK

Gene
ICL1
Protein
Isocitrate lyase
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Length
547 amino acids
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate (By similarity). plays an important role in plant pathogenicity.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
61.001 kDa
Sequence
MASKNMVNPAVEPSMEDDLFAREVAEVKQWWSDPRWRYTKRPFTAEQIVSKRGNLKIEYPSNAQSKKLWKILEGRFQKRDASYTYGCLEPTMVTQMAKYLDTVYVSGWQSSSTASSSDEPGPDLADYPYTTVPNKVSHLFMAQLFHDRKQRHERLSAPKSERSKLQNIDYLRPIIADADTGHGGLTAVMKLTKLFIEKGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLVAIRAQADIMGVDLLAIARTDAEAATLITTSIDPRDHAFILGCTNPSLQPLADLMNTAEQSGKTGDQLQAIEDEWMAKANLKRFDDAVVDVINSSSSIRNPKDVAAKYLQAAKGKSNREARAIASSLGVPEIFFDWDSPRTREGYFRIKGGCDCAINRAIAYAPYADAIWMESKLPDYEQAKEFAEGVHAVYPEQKLAYNLSPSFNWKTAMPRDEQETYIRRLAGLGYCWQFITLAGLHTTALISDRFARAYSEVGMRAYGELVQEPEMELGVDVVKHQKWSGATYVDELQKMVTGGVSSTAAMGKGVTEDQFH

Gene
ICL1
Protein
Isocitrate lyase
Organism
Magnaporthe oryzae (strain Y34)
Length
547 amino acids
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
61.028 kDa
Sequence
MASKNMVNPAVEPSMEDDLFAREVAEVKQWWSDPRWRYTKRPFTAEQIVSKRGNLKIEYPSNAQSKKLWKILEGRFQKRDASYTYGCLEPTMVTQMAKYLDTVYVSGWQSSSTASSSDEPGPDLADYPYTTVPNKVSHLFMAQLFHDRKQRHERLSAPKSERSKLQNIDYLRPIIADADTGHGGLTAVMKLTKLFIEKGAAGIHIEDQAPGTKKCGHMAGKVLVPINEHINRLVAIRAQADIMGVDLLAIARTDAEAATLITTSIDPRDHAFILGCTNPSLQPLADLMNTAEQSGKTGDQLQAIEDEWMAKANLKRFDDAVVDVINSSSSIRNPKDVAAKYLQAAKGKSNREARAIASSLGVPEIFFDWDSPRTREGYFRIKGGCDCAINRAIAYAPYADAIWMESKLPDYEQAKEFAEGVHAVYPEQKLAYNLSPSFNWKTAMPRDEQETYIRRLAGLGYCWQFITLAGLHTTALISDRFARAYSEVGMRAYGELVQEPEMELGVDVVKHQKWSGATYVDELQKMVTGGVSSTAAMGKGVTEDQFH

Gene
ICL1
Protein
Isocitrate lyase
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
546 amino acids
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
60.826 kDa
Sequence
MASQNMTNPSINPDIEDELFQKEVEAVKTWWSDSRWRQTKRPFTAEQIVSKRGYLPIDYASNTQAKKLWKILEHRFENRDASYTYGCLEPTMVTQMAKYLDTVYVSGWQSSSTASASDEPGPDLADYPYTTVPNKVGHLFMAQLFHDRKQRQERLSVPKEQRANLLNIDYLRPIVADADTGHGGLTAVMKLTKLFIEKGAAGIHIEDQAPGTKKCGHMAGKVLVPIQEHINRLVAIRAQADIMGSDLLAIARTDAEAATLLSTNIDPRDHAFILGSTNSTLKPLNDLMIAAEATGKSGAELQRIEDEWLAKANLSSFDDAVAAAIDAGSFSDKAGIKQEYTSRAKGKSNFEARAVARQLLGRDIFFDWDAPRTREGYFRLKGGCDCAVNRAIAYAPYCDAIWMESKLPDFAQAEQFAQGVHAVWPEKKLAYNLSPSFNWKTAMPRDEQETYIRRLAKLGYCWQFITLAGLHTTALISDQFAKAYSTVGMRAYGELVQEPEMDQKVDVVKHQKWSGATYVDELQKMVTGGISSTAAMGAGVTEDQFK

Gene
ICL1
Protein
Isocitrate lyase
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
542 amino acids
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
60.382 kDa
Sequence
MVSVKASAAEKKEFLQSQIDEIEKWWSEPRWKDTKRIYSAYEIAKRRGSVKPNTFPSTVMSQKLFKILGEHAKNGTVSKTFGALDPVQVTQMSKYLDTIYVSGWQCSSTASTSNEPGPDLADYPMDTVPNKVEHLFKAQQFHDRKQWERICDGTIEESEIIDYLTPIVADGDAGHGGLTAVFKLTKMFIERGAAGIHIEDQTSTNKKCGHMAGRCVIPVQEHINRLITCRMAADVLGSDLILVARTDSEAATLLSSTADSRDHYFILGASNPAVKGKPLNDLLNKAILDGATIDDLQTIEKEWLAKADVKLFHEVFADAAKAAGKDQSVIDQFNSKVNPLSETSIYEMQALAKELLGTELFFDWDLPRGREGLYRYQGGTQCSVMRARAFAPYADLCWMESNYPDYEQAKEFAEGVTAKFPGKWMAYNLSPSFNWTKAMSVDEQETFIQRLGDLGYIWQFITLAGLHTSGLAIEQFSKNFAKLGMKAYAQDIQKKELDNGIDMVKHQKWSGAEYIDGLLRLAQGGLAATAAMGQGVTEDQFK

Gene
icl1
Protein
Isocitrate lyase
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
538 amino acids
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
60.244 kDa
Sequence
MGFLEDEDQKYWDDVQAVKAWWKDSRWRYTKRPYTAEQIVAKRGNLKIHYPSNDQSKKLWKILESNFEKKVASFTYGCLEPTMLTQMAKYLDTVYVSGWQSSSTASSTDEPSPDLADYPMNTVPNKVNQLFMAQLFHDRKQREERITTPKDQRSKLPNIDYLRPIIADADTGHGGLTAVMKLTKLFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLVAIRAQADIMGTDLLAIARTDSEAATLITSTIDHRDHAFIVGSTNPNLQPLNDLMLAGEQAGKTGEELQAIEDQWIAQAGLKLFDDAVVDTIKAGVHVNKDALIKEYLTAAKGKSNSEARAIAKGITGVDIYWDWDAPRTREGYYRYQGGTQCAINRAVAYAPFADLIWMESKLPDYAQAKEFADGVHAVWPEQKLAYNLSPSFNWKKAMPREEQETYIKRLGALGYAWQFITLAGLHTTALISDQFARAYAKQGMRAYGELVQEPEMEQGVDVVTHQKWSGANYVDNMLKMLTGGVSSTAAMGKGVTEDQFKH

Gene
ICL1
Protein
Isocitrate lyase
Organism
Coccidioides immitis (strain RS)
Length
538 amino acids
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
60.383 kDa
Sequence
MSLSVEQEEQKYWEEVEAVKQWWKDSRWRYTKRPFTAEQIVAKRGNLKIEYPSNVQSKKLWKLVEEKFKTKTASFTYGCLDPTMVTQMVKYLDTVYVSGWQSSSTASSTDEPSPDLADYPMNTVPNKVNQLWMAQLFHDRKQREERLRNPKEKRASLANIDYLAPIIADADTGHGGLTAVMKLTKLFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLVAIRAQADIMGTDLLAIARTDSEAATLITSTIDPRDHAFVVGSTNPNLEPLNDLMIAAERAGKNGAELQAIEDSWTAKAGLKRFEDAVIDQIKASSAANKQAAIDAFLREIKGKSNKEARAIARQILGTDIFWDWDAPRTREGYYRYQGGCQCAINRAVAFAPFADLIWMESKLPDYAQAKEFAEGVHAVWPQQKLAYNLSPSFNWKAAMPRDEQETYIRRLGELGYCWQFITLAGLHTTALISDQFAKAYAKQGMRAYGELVQEPEMENKVDVVTHQKWSGANYVDELLKMVTGGVSSTSAMGKGVTEDQFK

Gene
ICL1
Protein
Isocitrate lyase
Organism
Leptosphaeria maculans
Length
537 amino acids
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate (By similarity). Plays an important role in plant pathogenicity.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
60.126 kDa
Sequence
MSHMDAEDAQFQKEVAEVKQWWNDSRWRYTKRTFTAEEIVSKRGNLKITYPSNSQSKKLWNIVEHRFKNKDVSYTYGCLDPVMVTQMAKYLDTVYVSGWQASSTASSTDEPGPDLADYPYTTVPNKVGHLFMAQLFHDRKQREERLTTPKADRAKVANVDYLRPIIADADTGHGGLTAIMKLTKLFIEKGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLVAIRAQADIMGTDLLAVARTDSEAATLITSTIDPRDHYYIQGCTNPALQPLSELMYAAEQSGKSGSELQAIEDAWVKEANLKLFHEAVVDTINAGVHVNKQELINQFLEQSKGKSNAEARTIAQGLTGVDVYFNWDAARTREGYYRYKGGCQCAINRAIAYAPFCDMIWMESKLPDYAQAKEFADGVHAVWPEQKLAYNLSPSFNWKAAMPRDEQETYIQRLAQLGYCWQFITLAGLHQSALMADTFSKAYSKQGMRAYGEIIQEPEAENKVDVLTHQKWSGANYVDNMLKMVSGGVSSTAAMGKGVTEDQFK

Gene
icl1
Protein
Isocitrate lyase 1
Organism
Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Length
428 amino acids
Function
Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. It also catalyzes the formation of pyruvate and succinate from 2-methylisocitrate, a key step in the methylcitrate cycle (propionate degradation route).
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
47.087 kDa
Sequence
MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGSTEEGQFH

Gene
icl1
Protein
Isocitrate lyase 1
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
428 amino acids
Function
Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. It also catalyzes the formation of pyruvate and succinate from 2-methylisocitrate, a key step in the methylcitrate cycle (propionate degradation route).
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Mass
47.087 kDa
Sequence
MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGSTEEGQFH