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HTRA2

Gene
HTRA2
Protein
Serine protease HTRA2, mitochondrial
Organism
Bos taurus
Length
458 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis (By similarity).
Similarity
Belongs to the peptidase S1C family.
Mass
49.163 kDa
Sequence
MAALRAGRGAGWSLRGWRALWGGRWGKGPLLTPDLRALLTSGTPDPRTRVTYGTPSFRARLSVGVPEPRTCLRSRTSDLRARLIAGTPDPRTPEDSGTPGTRLRVWLAVALGAGGAVLLLFWGGGRGPPAVLASVLGSPPTSPRSQYNFIADVVEKTAPAVVYIEILGRHPFSGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLPSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPAKDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTSGISFAIPSDRLREFLHRGEKKNSWFGISGSQRRYIGVMMLTLTPSILAELQLREPSFPDVQHGVLIHKVILDSPAHRAGLRPGDVILAIGEQLVQNAEDIYEAVRTQSQLAVRIRRGQETLTLYVTPEVTE

Gene
HTRA2
Protein
Serine protease HTRA2, mitochondrial
Organism
Homo sapiens
Length
458 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Similarity
Belongs to the peptidase S1C family.
Mass
48.841 kDa
Sequence
MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE

Gene
Htra2
Protein
Serine protease HTRA2, mitochondrial
Organism
Mus musculus
Length
458 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis (By similarity).
Similarity
Belongs to the peptidase S1C family.
Mass
49.348 kDa
Sequence
MAALKAGRGANWSLRAWRALGGIFWRKPPLLAPDLRALLTSGTPDSQIWMTYGTPSLPAQVPEGFLASRADLTSRTPDLWARLNVGTSGSSDQEARRSPGSRRREWLAVAVGAGGAVVLLLWGWGRGLSTVLAAVPAPPPTSPRSQYNFIADVVEKTAPAVVYIEILDRHPFSGREVPISNGSGFVVASDGLIVTNAHVVADRRRVRVRLPSGDTYEAMVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQNNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSWFGTSGSQRRYIGVMMLTLTPSILIELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEKLAQNAEDVYEAVRTQSQLAVRIRRGSETLTLYVTPEVTE

Gene
HtrA2
Protein
Serine protease HTRA2, mitochondrial
Organism
Drosophila willistoni
Length
434 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
Similarity
Belongs to the peptidase S1C family.
Mass
47.589 kDa
Sequence
MAFRRINNLELFIKRCSAPTLYYSSIRTATGNNYSNNTANITTDSSSSSNNNSNRNNKNDNNNEDNNKFNWRSLVRFFVPFSLGAVASSLVMKRDDLELTPTISAARPSGRRREFNFIADVVGGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFVIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLPVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAERRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSNLMHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALGCGDKELNMIIMRGVKQMHVTITPEDP

Gene
HtrA2
Protein
Serine protease HTRA2, mitochondrial
Organism
Drosophila mojavensis
Length
430 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
Similarity
Belongs to the peptidase S1C family.
Mass
46.847 kDa
Sequence
MALRSINKLNVFVKRCATTLLYCRHKSAPSALNTNSASSPTSTNSSRNNNNKNEDDNRNNKNGFSGYSWRSAIRFFVPFSLGALASTMVAQREELTPTISARTLNGRRREFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFVIEQNGLILTNAHVVINKPNTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSVMKLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAARRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRTQNMPNTLSHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADGKKELDIVILRGVKQMRVTITPEDP

Gene
HtrA2
Protein
Serine protease HTRA2, mitochondrial
Organism
Drosophila persimilis
Length
427 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
Similarity
Belongs to the peptidase S1C family.
Mass
46.43 kDa
Sequence
MALRCINNLEIFLRRCTAPTLHRCCVASSRTAHTASSSKGSGGDNSKDQENNGQNKSGYRRFGWRSVFQFCVPFSLGALVSAVLIEGHRDELTPTISARSLKGRRNEFNFIADVVAGCGDSVVYIEIKDTRHFDYFSGQPITASNGSGFVIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIHVSGLPVMKLGKSSTLRSGEWVVALGSPLALSNTVTAGVISATQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAERRKKGSAHKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPNNLMHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALAEGRKDLEIVILRGVKQMHVKITPEDP

Gene
HtrA2
Protein
Serine protease HTRA2, mitochondrial
Organism
Drosophila pseudoobscura pseudoobscura
Length
427 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
Similarity
Belongs to the peptidase S1C family.
Mass
46.423 kDa
Sequence
MALRCINNLEIFLRRCTAPTLHRCCVASSRTAHTASSSKGSGGDNSKDKENNGQNKSGYRSFGWRSAFQFCVPFSLGALVSAVLIERHRDELTPTISARSLKGRRNEFNFIADVVAGCGDSVVYIEIKDTRHFDYFSGQPITASNGSGFVIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVSGLPVMKLGKSSTLRSGEWVVALGSPLALSNTVTAGVISATQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAERRKKGSAHKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPNNLMHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALAEGRKDLEIVILRGVKQMHVKITPEDP

Gene
HtrA2
Protein
Serine protease HTRA2, mitochondrial
Organism
Drosophila ananassae
Length
426 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
Similarity
Belongs to the peptidase S1C family.
Mass
46.723 kDa
Sequence
MALRGSHRLDDFIRRCSALTLFHSQAPSRRVSHCGRDRRQQQDPPGQGRQEQQESGGGHWSRFGWRSLIRFFVPFSLGAVASSLVIKREELTPTITAKAMSGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVSNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAERRKKGAAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKHLDIVILRGVKQMHVTITPEDP

Gene
HtrA2
Protein
Serine protease HTRA2, mitochondrial
Organism
Drosophila grimshawi
Length
426 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
Similarity
Belongs to the peptidase S1C family.
Mass
46.552 kDa
Sequence
MALRSITKLETFLKRYSAPTLYYCLHRSTQSSTCNSTNTDNGSHNTNYNSSNNNNNNNDNKRFSWRSAIRFLVPFSLGALASSVVAGDRELMPTISAKTLTNNRRDFNFIADVVASCADSVVYIEIKDTRHFDYFSGQPITASNGSGFVIEQNGLILTNAHVVINKPNTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVTNLSVMKLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKLFLERAAARRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRTQNMPETLSHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADGKKDLDMVILRGVKQMRVTITPEDP

Gene
HtrA2
Protein
Serine protease HTRA2, mitochondrial
Organism
Drosophila erecta
Length
422 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
Similarity
Belongs to the peptidase S1C family.
Mass
45.845 kDa
Sequence
MALRGSHRLQVILKRCIASPLFHSHAPNRRSSQPAIKGGEPNSNGNSGHDQQNGERKGKGWRRLVSFFVPFSLGAVVSAAVIKREDFTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKNLDIVILRGVKQMHVTITPEDP

Gene
HtrA2
Protein
Serine protease HTRA2, mitochondrial
Organism
Drosophila melanogaster
Length
422 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th.
Similarity
Belongs to the peptidase S1C family.
Mass
46 kDa
Sequence
MALRGSHRLEVIFKRCIASPVLHSHAANRRSSQLAIKEGDPNSNGNSGQYQQNGEQKEKGWRRLVRFFVPFSLGAVVSAAIIQREDLTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVKQMHVTITPEDP

Gene
HtrA2
Protein
Serine protease HTRA2, mitochondrial
Organism
Drosophila sechellia
Length
422 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
Similarity
Belongs to the peptidase S1C family.
Mass
45.927 kDa
Sequence
MALRGSHRLEVIFKRCIASPVLHSQAGNRRSSQLAIKGVDPNSNGNSGQYQQNGEHKEKGWRRLVRFFVPFSLGAAVSAAIIQREDLTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVKQMHVTITPEDP

Gene
HtrA2
Protein
Serine protease HTRA2, mitochondrial
Organism
Drosophila simulans
Length
422 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
Similarity
Belongs to the peptidase S1C family.
Mass
46.005 kDa
Sequence
MALRGCHRLEVIFKRCIASPVLHSQAGNRRSSQLAIKGVDPNSNGNSGQYQQNGEHKEKGWRRLVRFFVPFSLGAAVSAAIIQREDFTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPNNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVKQMHVTITPEDP

Gene
HtrA2
Protein
Serine protease HTRA2, mitochondrial
Organism
Drosophila yakuba
Length
422 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
Similarity
Belongs to the peptidase S1C family.
Mass
45.9 kDa
Sequence
MALRGSHRLEVIFKRCIASPVFHSHAANRRSSQLAIKGTDPSSNGNSGQDQQNGEQKAKGWRRLVRFFVPFSLGAAVSAAVIKREDFTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSHLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKNLDIVILRGVKQMHVTITPEDP

Gene
HtrA2
Protein
Serine protease HTRA2, mitochondrial
Organism
Drosophila virilis
Length
421 amino acids
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
Similarity
Belongs to the peptidase S1C family.
Mass
45.903 kDa
Sequence
MALRSINKLEVFLKRYSAPTLYYCSNKSAHGATNGIGTDDSNNNYNNNNKNKNGYTGFSWRSVIRFFVPFSLGALASTMVAQREELTPTISARALSGRRREFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFVIEQNGLILTNAHVVINKPNTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSVMKLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAARRRKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRTQNMPNTLSHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADGKKELDIVILRGVKQMRVTITPEDP