Protein
Heat shock protein beta-6
Function
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.
Similarity
Belongs to the small heat shock protein (HSP20) family.
Sequence
MEIPVSVQPSWLRRASAPLPGLSAPGRLFDQRFGEGLLEAELAALCPAALAPYYLRAPSVALPTAQVSTDPGHFSVLLDVKHFSPEEIAVKVVGDHVEVHARHEERPDEHGYIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQAAPAPAQAPLQSPPGAAAK