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HSP78

Gene
HSP78
Protein
Heat shock protein 78, mitochondrial
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
812 amino acids
Function
Required, in concert with mitochondrial Hsp70, for the dissociation, resolubilization and refolding of aggregates of damaged proteins in the mitochondrial matrix after heat stress. May extract proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by the Hsp70 chaperone system. Required for resumption of mitochondrial respiratory function, DNA synthesis and morphology after heat stress (By similarity).
Similarity
Belongs to the ClpA/ClpB family.
Mass
91.657 kDa
Sequence
MLSSRIPKGKLLKQTSATSYLNLAKSMPITTARYRPNQYYANELAKLNVFTIHNIPSPCFSQVRNFHSSFPRKLQMQQTEQGDNRPALEKFGSDLTQLAKEGKLDPVIGRDHEIRRTIQILSRRTKNNPVLIGNAGTGKTAVMEGLAQRIIRGEVPDSMKDKQIITLDLAGIISGAKYRGDFESKLKSILKEVEEKNGKVILFIDEFHLLMGLGKAEGSIDASNLLKPALARGKLSMCGATTIEEYRKYVEKDAALARRFSPVTVNEPTVEDTISILRGLKERYEVHHGVRIMDSALVTAALYSNRYITDRFLPDKAIDLVDEASSTLRLQHESRPDAIATLDRQIMTIEIELESLRKEEDQLSIDRKHKLEKELEVKKSELKELTDQWESEKRAIDAVKNAKSELEKAKYELEQATREGDYARASRIQYASIPELQDKIQELSKNELAAKSSNLLHDSVTSEDIAGVISKMTGIPVNNLLKGEKDKLLDMNILLRQSVVGQDEAIDAVSDAVRLQRAGLTSENRPIASFMFLGPTGTGKTEGGKSLAQFLFNDKNAVVRFDMSEFQEKHTISRLIGSPPGYVGYEESGELTEAVRRKPYSVVLFDEFEKAHPDLSKLLLQVLDEGSLTDSHGKKIDFKNTIIVMTSNIGQEILLADKNTYEDGHINSEVKSQVLENLRHHYAPEFLNRIDDIVVFNRLSKTALKEILDIRLREIGDRLVDKRIILQLTDEAKTLLCDMGYDPTYGARPLNRVLRKKLLDPLAMRLIKGQVQENETVKVEVKDHKIYVVPNHSEGTVIEKEEDYFKEDKDDN

Gene
HSP78
Protein
Heat shock protein 78, mitochondrial
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
811 amino acids
Function
Required, in concert with mitochondrial Hsp70 (SSC1), for the dissociation, resolubilization and refolding of aggregates of damaged proteins in the mitochondrial matrix after heat stress. May extract proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by the Hsp70 chaperone system. Required for resumption of mitochondrial respiratory function, DNA synthesis and morphology after heat stress. Its main role may be maintaining the molecular chaperone SSC1 in a soluble and functional state. Also required for the efficient degradation of proteins by matrix protease PIM1, independent on its protein remodeling activity.
Similarity
Belongs to the ClpA/ClpB family.
Mass
91.336 kDa
Sequence
MLRQATKAPIQKYLQRTQLLRRSTPRIYTIVQCKRSICSFNARPRVANKLLSDIKTNALNEVAISTCALKSSYGLPNFKRTYVQMRMDPNQQPEKPALEQFGTNLTKLARDGKLDPVIGRDEEIARAIQILSRRTKNNPCLIGRAGVGKTALIDGLAQRIVAGEVPDSLKDKDLVALDLGSLIAGAKYRGEFEERLKKVLEEIDKANGKVIVFIDEVHMLLGLGKTDGSMDASNILKPKLARGLRCISATTLDEFKIIEKDPALSRRFQPILLNEPSVSDTISILRGLKERYEVHHGVRITDTALVSAAVLSNRYITDRFLPDKAIDLVDEACAVLRLQHESKPDEIQKLDRAIMKIQIELESLKKETDPVSVERREALEKDLEMKNDELNRLTKIWDAERAEIESIKNAKANLEQARIELEKCQREGDYTKASELRYSRIPDLEKKVALSEKSKDGDKVNLLHDSVTSDDISKVVAKMTGIPTETVMKGDKDRLLYMENSLKERVVGQDEAIAAISDAVRLQRAGLTSEKRPIASFMFLGPTGTGKTELTKALAEFLFDDESNVIRFDMSEFQEKHTVSRLIGAPPGYVLSESGGQLTEAVRRKPYAVVLFDEFEKAHPDVSKLLLQVLDEGKLTDSLGHHVDFRNTIIVMTSNIGQDILLNDTKLGDDGKIDTATKNKVIEAMKRSYPPEFINRIDDILVFNRLSKKVLRSIVDIRIAEIQDRLAEKRMKIDLTDEAKDWLTDKGYDQLYGARPLNRLIHRQILNSMATFLLKGQIRNGETVRVVVKDTKLVVLPNHEEGEVVEEEAEK

Gene
hsp78
Protein
Heat shock protein 78, mitochondrial
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
803 amino acids
Function
Required, in concert with mitochondrial Hsp70, for the dissociation, resolubilization and refolding of aggregates of damaged proteins in the mitochondrial matrix after heat stress. May extract proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by the Hsp70 chaperone system. Required for resumption of mitochondrial respiratory function, DNA synthesis and morphology after heat stress (By similarity).
Similarity
Belongs to the ClpA/ClpB family.
Mass
90.154 kDa
Sequence
MNILPKSIPIRIQSLRRYQGSLKTSLRALSTRPIFEKRLLAETPFSIRPSNASVLIAKRSPKFGWKQVRFYAANPNGGNFRMDLGGGRKQGAALEEYGTDLTALAKQGKLDPVIGREEEIQRTIQILSRRTKNNPALVGPAGVGKTAIMEGLASRIIRGEVPESMKDKRVIVLDLGALISGAKFRGDFEERLKSVLSDLEGAEGKVILFVDEMHLLLGFGKAEGSIDASNLLKPALARGKLHCCGATTLEEYRKYIEKDAALARRFQAVMVNEPSVADTISILRGLKERYEVHHGVRITDDALVTAATYSARYITDRFLPDKAIDLVDEACSSLRLQQESKPDELRRLDRQIMTIQIELESLRKETDTTSVERREKLESKLTDLKEEQDKLSAAWEEERKLLDSIKKAKTELEQARIELERTQREGNYARASELQYAIIPELERSVPKEEKTLEEKKPSMVHDSVTSDDIAVVVSRATGIPTTNLMRGERDKLLNMEQTIGKKIIGQDEALKAIADAVRLSRAGLQNTNRPLASFLFLGPTGVGKTALTKALAEFLFDTDKAMIRFDMSEFQEKHTIARLIGSPPGYIGYEESGELTEAVRRKPYAVLLFDELEKAHHDITNLLLQVLDEGFLTDSQGRKVDFRSTLIVMTSNLGSDILVADPSTTVTPKSRDAVMDVVQKYYPPEFLNRIDDQIVFNKLSEKNLEDIVNVRLDEVQQRLNDRRIILTVTEAARKWLAEKGYSPAYGARPLNRLIQKRILNTMAMKIIQGEIKSDENVVIDVLDGELEFKANKLEPQSTSHED