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HSK3

Gene
HSK3
Protein
DASH complex subunit HSK3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
69 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids.
Similarity
Belongs to the DASH complex HSK3 family.
Mass
8.088 kDa
Sequence
MNANKQRQYNQLAHELRELQTNLQETTKQLDIMSKQCNENLVGQLGKVHGSWLIGSYIYYMEQMLGKTQ

Gene
HSK3
Protein
DASH complex subunit HSK3
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
68 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
Similarity
Belongs to the DASH complex HSK3 family.
Mass
7.971 kDa
Sequence
MDQTKRRHYSQLSQQLQLLQKNLEATTQHVETMSVQCNEHLVNKLGKIQASWFIGGNRCFEQELLGKR