Protein
17-beta-hydroxysteroid dehydrogenase type 6
Function
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids (By similarity).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Sequence
MWLYLAVLLGLYYLLRWFRERQVVSHLQDKFVFITGCDSGFGNQLARQLDLRGLRVLAGCLTEQGAEQLRNQTSDRLQTVILDVTKTESIAAATEWVKECVGDRGLWGLVNNAGIFHSHGYAEWIKIETYRDTLRVNLIGVIEVTLSMLPLVRKAQGRIVNVSSILGRIAFFGAVYSCSKYGVEAFSDILRRELQHFGVKVSMVEPGYFRTAMTDWQKFSEIMKQIWKETPAHIKETYGQKFFDAYHDLMKQGLLSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFVPLSYLPTSLADYILTRSWPKPAQAV