HNF1A

Hepatocyte nuclear factor 1-alpha

634 amino acids

Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. May participate in the control of the hormone-dependent expression of the lysozyme gene in the oviduct and liver. In liver it could repress the gene while in oviduct it may act as an activator.

Belongs to the HNF1 homeobox family.

69.189 kDa

MVSKLSHLQVELLGALLESGLTKETLIKGLSEAEPYVLQSESQHAINALQTEKGESCPEIPNLPNGMGETRLSEDETSDDGEEFTPPIMKELENLSPEEAAHQKAVVERLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGILTEEPMGDDLPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEEREALVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDNFSGPQPTSAPPLTPHNSSSLQPPPALSPTKVHGVRYNQQPASEAESSSSNHHGNSSMVTTQTILHQVSPPGLEPSQNLLSTDTKLISAPGGTLPPVSTLTALHSLEQNPHALGQQTQNLIMASLPGVMAIGAGETSSLAPRFTNTGGSTLVIGLTSTQPQSVPVINSMGSSLTTLQPVQFSQQLHPSYQQPLMQQVQSHINQSPFMATMAQIQNPHALYGPKSEVAQYTHTGLLPQTMVITDTANLSALTNLTPTKQAFTSDSETHTDSGIHTPVSQAPAIHLQNQDTAIQHLQSGPRLTPSPAVSSSSLVLYQSSDSTNSHSQLLPSTHNVIETFISTQMASSTQ

HNF1A

Hepatocyte nuclear factor 1-alpha

631 amino acids

Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:12453420, PubMed:10966642). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity).

Belongs to the HNF1 homeobox family.

67.356 kDa

MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSHSLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPHALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTKQVFTSDTEASSESGLHTPASQATTLHVPSQDPAGIQHLQPAHRLSASPTVSSSSLVLYQSSDSSNGQSHLLPSNHSVIETFISTQMASSSQ

Hnf1a

Hepatocyte nuclear factor 1-alpha

628 amino acids

Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (PubMed:19289501). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:10966642). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (PubMed:30555544).

Belongs to the HNF1 homeobox family.

67.253 kDa

MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGEGPLDKGESCGGSRGDLTELPNGLGETRGSEDDTDDDGEDFAPPILKELENLSPEEAAHQKAVVESLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGPALPAHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGGPLVTVSAALHQVSPTGLEPSSLLSTEAKLVSATGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVAQSPFMATMAQLQSPHALYSHKPEVAQYTHTSLLPQTMLITDTNLSTLASLTPTKQVFTSDTEASSEPGLHEPPSPATTIHIPSQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQSSDSNGHSHLLPSNHSVIETFISTQMASSSQ

Hnf1a

Hepatocyte nuclear factor 1-alpha

628 amino acids

Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity).

Belongs to the HNF1 homeobox family.

67.213 kDa

MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGDGPLDKGESCGGTRGDLTELPNGLGETRGSEDDTDDDGEDFAPPILKELENLSPEEAAHQKAVVESLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGPALPAHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGGPLVTVSAALHQVSPTGLEPSSLLSTEAKLVSATGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVAQSPFMATMAQLQSPHALYSHKPEVAQYTHTSLLPQTMLITDTNLSTLASLTPTKQVFTSDTEASSEPGLHEPSSPATTIHIPSQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQSSDSNGHSHLLPSNHGVIETFISTQMASSSQ

hnf1a

Hepatocyte nuclear factor 1-alpha

559 amino acids

Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreas and liver (By similarity). Binds to the promoter of the albumin gene.

Belongs to the HNF1 homeobox family.

61.531 kDa

MEGEERKGEAGPGPGRLSALQEQLIWALLGSGLSREVLVHALGELERERVTPGAEKGDRGDGESSEEGEMDFPPPIFQELEALAPEEAARQRALVDQLLQEDPWRVAKLVKSYMQQHNLPQREVVESIGLNQSHLSQHLNKGTPMKNQKRAALYSWYVRKQGEISQQFTNARHALGSGEEQGEDVRKGRRNRFKWGPASQQILFHAYERQRNPSKEEREGLVEECNRAECLQRGVSPSQLAGLGSNLVTEVRVYNWFANRRKEEAFRHKLALDMPYNSQSASSTNHTLSHSPEQGMKYSQQITCDNLGSSRGHNGDRGLGGRLASPIQLEPSHTLLETHHHKPVSGGGPLPPVSTLTSLHSLSASPAPHHGLIMTSLPSVMSLGESSLLIGQTVPVINNVGGGFTTLQPISFQQQLHSTSQQQLTQQFQSHMGHHHSPFMATMAQLPCHMYSKSDMSHYPPSSLLSQAMVITDSSSLGTLTSLTTVRQILTTDPEEQTDQPIQEDSLHLQSPSPVPVSSGNLQLYPPSQSSESHPPHRLSSSPADINSYIPAQMVSTAQ