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HMGR

Gene
HMGR
Protein
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Organism
Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)
Length
1183 amino acids
Function
Catalyzes the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis (By similarity).
Similarity
Belongs to the HMG-CoA reductase family.
Mass
127.666 kDa
Sequence
MAAILLPQRFRGEAPVTEKTTPSWASKRLTPIAQFLSRLACSHPIHTVVVVAVLASTSYVGLLQESLFNTDVESATLGKADWSTLVEGSRVLRAGPETAWNWKAVEQDVVADAGSDADHLALLTLVFPDSLSAESSSTAPRSHHVPIPQNLSITSLPSTENPFTAYSQDSILAYALPYSEGPEFLAAAQEIPNEDAVEIETKHGREKKTWIMKAAKVNTRNSVVQWVSNAWSEFLDLLKNAETLDIVIMLLGYIAMHLTFVSLFLSMRKMGSKFWLGICTLFSSVFAFLFGLVVTTKLGVPISVILLSEGLPFLVVTIGFEKNIVLTRAVMSHAIEHRRIQAQNSKSGKRSPERSTQNMIQYAVQAAIKEKGFEIIRDYAIEIVILVIGAASGVQGGLQQFCFLAAWTLFFDFILLFTFYTAILSIKLEINRIKRHVDMRMALEDDGVSRRVAENVAKGDDELNRVRGDAPLFGRKSSSIPKFKVLMILGFIFVNIVNICSIPFRNPSSMSTIRTWASSLGGVIAPLSVDPFKVASNGLDAILATAKSNNRPTLVTVLTPIKYELEYPSIHYALGSAASNPAYNDAFHHHFQGYGVGGRMVGGILKSLEDPVLSKWIVIALALSVALNGYLFNVARWGIKDPNVPEHNIDRNELARAQQFNDTGSATLPLGEYVPPTPMRTQPSTPAITDDEAEGLHMTKARPANLPNRSNEELEKLLSEKRVREMTDEEVISLSMRGKIPGYALEKTLGDFTRAVKIRRSIIARNKATTDITHSLDRSKLPYENYNWERVFGACCENVIGYMPLPVGVAGPLVIDGQSYFIPMATTEGVLVASASRGCKAINSGGGAITVLTADGMTRGPCVAFETLERAGAAKLWLDSEAGQDMMKKAFNSTSRFARLQSMKTALAGTNLYIRFKTTTGDAMGMNMISKGVEHALSVMANDGGFDDMQIISVSGNYCTDKKAAALNWIDGRGKGVVAEAIIPGEVVRSVLKSDVDSLVELNVAKNLIGSAMAGSVGGFNAHAANIVAAIFLATGQDPAQVVESANCITIMKNLNGALQISVSMPSLEVGTLGGGTILEPQGAMLDILGVRGSHPTNPGDNARRLARIIGAAVLAGELSLCSALAAGHLVRAHMQHNRSAAPSRSTTPAPPMTPVSLAMTSAQERSASTTSMSAAAIQRSKR

Gene
HMGR
Protein
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Organism
Gibberella fujikuroi
Length
976 amino acids
Function
Catalyzes the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis (By similarity).
Similarity
Belongs to the HMG-CoA reductase family.
Mass
105.395 kDa
Sequence
MDHEGCQGQHPQQCCQWVSNAWSEFLDLLKNAETLDIVIMLLGYIAMHLTFVSLFLSMRKMGSKFWLGICTLFSSVFAFLFGLVVTTKLGVPISVILLSEGLPFLVVTIGFEKNIVLTRAVMSHAIEHRRIQAQNSKSGKRSPDGSTQNMIQYAVQAAIKEKGFEIIRDYAIEIVILVIGAASGVQGGLQQFCFLAAWTLFFDFILLFTFYTAILSIKLRSTVSSVMSICVWPLRMMASRRVAENVAKGDDELNRVRGDAPLFGRKSSSIPKFKVLMILGFIFVNIVNICSIPFRNPSSMSTIRTWASSLGGVIAPLSVDPFKVASNGLDAILPTAKSNNRPTLVTVLTPIKYELEYPSIHYALGSAASNPAYNDAFHHHFQGYGVGGRMVGGILKSLEDPVLSKWIVIALALSVALNGYLFNVARWGIKDPNVPEHNIDRNELARAREFNDTGSATLPLGEYVPPTPMRTQPSTPAITDDEAEGLHMTKARPANLPNRSNEELEKLLSENALREMTDEEVISLSMRGKIPGYALEKTLGDFTRAVKIRRSIIARNKAAADITHSLDRSKLPYENYNWERFFGACCENVIGYMPLPVGVAGPLVIDGQSYFIPMATTEGVLVASASRGCKAINSGGGAITVLTADGMTRGPCVAFETLERAGAAKLWLDSEAGQDMMKKAFNSTSRFARLQSMKTALAGTNLYIRFKTTTGDAMGMNMISKGVEHALSVMANDGGFDDMQIISVSGNYCTDKKAAALNWIDGRGKGVVAEAIIPGEVVRSVLKSDVDSLVELNVAKNLIGSAMAGSVGGFNAHAANIVAAIFLATGQDPAQVVESANCITIMKNLNGALQISVSMPSLEVGTLGGGTILEPQGAMLDILGVRGSHPTNPGDNARRLARIIGAAVLAGELSLCSALAAGHLVRAHMQHNRSAAPSRSTTPGSSHDARLTGHDQCPRALSVNNVDERRRYSEVKAIDE

Gene
HMGR
Protein
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Organism
Agrotis ipsilon
Length
833 amino acids
Function
Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation.
Similarity
Belongs to the HMG-CoA reductase family.
Mass
89.79 kDa
Sequence
MKVWGAHGEFCARHQWEVIVATLALLACAASVERNGPGNRSEHCAGWARACPGLEAEYQAADAVIMTFVRCAALLYAYYQISNLHKIASKYLLIIAGVFSTFASFIFTSAVASLFWSELASIKDAPFLFLLVADVARGARMAKAGWSAGEDQGKRVGRALALLGPTATLDTLLAVLLVGVGALSGVPRLEHMCTFACLALLVDYLVFVTFYPACLSLVADFASGRKEMSPDSPFSEADLKPNPVVQRVKMIMAAGLLCVHLTSRWPWSSDNGIIEGPTDTLTPTSNDNILLHSYVKWFSVSADYIVIATLLCALIIKFVFFEEQRNWVIDMNDMTVKEVVQEQARSKPKFSVGDDSNSEVSTQTEGVLEDEWPTLSPSSSAAKLNSKKRPMAECLEIYRSEGACVSLSDEEVVMLVEQSHIPLHRLEAVLGDPLRGVRLRRKVVGARFQTELAIKQLPYLNYDYSKVLNACCENVIGYVGVPVGYAGPLVVDGKPYMIPMATTEGALVASTNRGAKAIGIRGVTSVVEDVGMTRAPAIKLPNVVRAHECRQWIDNKDNYAVIKEAFDSTSRFARLQEIHIGVDGATLYLRFRATTGDAMGMNMVSKGAENALKLLKNYFPDMEVISLSGNYCSDKKAAAINWVKGRGKRVVCETTITSDSLRTIFKTDAKTLARCNKIKNLSGSALAGSIGGNNAHAANMVTAIYIATGQDPAQNVTSSNCSTNMEVCGENGEDLYVTCTMPSLEVGTVGGGTILTGQGACLDILGVKGAGARPAENSARLASLICATVLAGELSLMAALVNSDLVKSHMRHNRSTVNVQVQAENITLKVPTL

Gene
HMGR
Protein
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Organism
Nicotiana sylvestris
Length
604 amino acids
Function
Catalyzes the synthesis of mevalonate, the specific precursor of all isoprenoid compounds present in plants. Possible role in plant defense mechanisms as well as in the cell cycle.
Similarity
Belongs to the HMG-CoA reductase family.
Mass
65.085 kDa
Sequence
MDVRRRSEKPAYPTKEFAAGEKPLKPHKQQQEQDNSLLIASDALPLPLYLTNGLFFTMFFSVMYYLLSRWREKIRNSTPLHVVTFSELVAIASLIASVIYLLGFFGIGFVQSFVSRDNNDECWDEEDENDEQFLLEEDSRRGPATTLGCTAVPPPPALQIVPMVPPQPSKVAAMSEKPAPLVTPAASEEDEEIIKSVVQGKMPSYSLESKLGDCKRAASIRKEALQRITGKSLEGLPLEGFDYESILGQCCEMPIGYVQIPVGIAGPLLLDGREYSVPMATTEGCLVASTNRGCKAIYASGGATSVLLRDGMTRAPCVRFGTAKRAAELKFFVEDPVKFETLAAVFNQSSRFARLQRIQCAIAGKNLYMRFVCSTGDAMGMNMVSKGVQNVLDYLQNEYPDMDVIGISGNFCSDKKPAAVNWIEGRGKSVVCEAIITEEVVKKVLKTEVAALVELNMLKNLTGSAMAGALGGFNAHASNIVSAVYIATGQDPAQNIESSHCITMMEAVNDGKDLHVSVTMPSIEVGTVGGGTQLASQSACLNLLGVKGANREVPGSNARLLATIVAGSVLAGELSLMSAISAGQLVKSHMKYNRSTKDVTKASS

Gene
HMGR
Protein
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Organism
Catharanthus roseus
Length
601 amino acids
Function
Catalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants.
Similarity
Belongs to the HMG-CoA reductase family.
Mass
64.107 kDa
Sequence
MDSRRRSPTVTAKAAAGELPLAPHEGQNQQPSIPRSSDVLPLPLYLANGVFFTLFFSVMYFLLTRWREKIRNATPLHVVTLSELAALASLIASVIYLVSFFGLDFVQSLIYKPNNEGWEIEEEILMVEDSRNGTNCTTLGCAVPPPSVPKIAPVVPQQPSKMVIIEKPAPLITPQNSEEDEDIIKAVVAGKIPSYSLESKLGDCKRAAGIRREALQRITGKSLEGLPLEGFDYASILGQCCEMPVGYVQLPVGIAGPLLLDGREYMLPMATTEGCLVASTNRGCKAILASGGANSVLLRDGMTRAPVVRFGTAKRAAELKFYMEDTQNFETISVVFNKSSRFAKLQSVQCAIAGKNLYIRFSCSTGDAMGMNMVSKGVQNVLEFLQTDYPDMDVLGISGNFCADKKPAAVNWIEGRGKSVVCEAIIKEEIVKTVLKTEVAALIELNMVKNLAGSAIAGALGGFNAHASNIVSAIFIATGQDPAQNVESSQCITMMEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACLNLLGVKGASKDSPGANSRLLATIVAGSVLAGELSLMSAISAGQLVRSHMKYNRSSKDITNIASSQLESDS

Gene
HMGR
Protein
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Organism
Zea mays
Length
579 amino acids
Function
Catalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants.
Similarity
Belongs to the HMG-CoA reductase family.
Mass
60.931 kDa
Sequence
MEVRGGVGQGSAARHPPAPEPSRAAARVQAGDALPLPIRHTNLIFSALFAASLAYLMRRWREKIRSSTPLHAVGLAEMLAIFGLVASLIYLLSFFGIAFVQSIVSSGDDDEDFLVGSGSSGSAAAPSRQHAQAPAPCELLGSPAAAPEKMPEDDEEIVASVVAGKVPSYALEARLGDCRRAAGIRREALRRITGRDIEGLPLDGFDYASILGQCCELPVGYVQLPVGVAGPLLLDGRRFYLPMATTEGCLVASTNRGCKAIAESGGATSVVLRDAMTRAPVARFPTARRAAELKAFLEDPANFDTLSVVFNRSSRFARLQGVQCAMAGRNLYMRFSCSTGDAMGMNMVSKGVQNVLDFLQDDFHDMDVISISGNFCSDKKPSAVNWIEGRGKSVVCEAVIGEEVVKKVLKTDVQSLVELNTIKNLAGSAVAGALGGFNAHASNIVTAIFIATGQDPAQNVESSHCITMLEPVNAGRDLHISVTMPSIEVGTVGGGTQLASQSACLDLLGVRGASRDRPGSNARLLATVVAGGVLAGELSLLSALAAGQLVKSHMKYNRSSKDVSSTTATEKTRQREVDV