HMGCS-1

Hydroxymethylglutaryl-CoA synthase 1

453 amino acids

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

50.332 kDa

MWPSDVGIVALELIFPSQYVDQVDLEVYDNVSAGKYTVGLGQARMGFCTDREDINSLCLTVVSRLMERWSIPYSQIGRLEVGTETLLDKSKSVKTVLMQLFKDNTDIEGVDTVNACYGGTSALFNAISWVESSSWDGRYALVVAGDIAVYAKGSARPTGGAGAVAMLVGANAPLVFDRGVRSSHMQHAYDFYKPDLSSLYPTVDGKLSIQCYLSALDHCYQLYCSKIQKQLGEKFDIERLDAVLFHAPYCKLVQKSLARLVLNDFVRASEEERTTKYSSLEALKGVKLEDTYFDREVEKAVMTYSKNMFEEKTKPSLLLANQVGNMYTPSLYGGLVSLLVSKSAQELAGKRVALFSYGSGLASSMFSLRISSDASAKSSLQRLVSNLSHIKPQLDLRHKVSPEEFAQTMETREHNHHKAPYTPEGSIDVLFPGTWYLESVDSLYRRSYKQVPG