Protein
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Organism
Cyberlindnera jadinii
Function
Catalyzes the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.
Similarity
Belongs to the HMG-CoA reductase family.
Sequence
MFYHGASANQHWIAVDDLSKVPVDVDHYNVVPFQFRRAGEYKEPVLSGIVELDEVKFVVSQSDAAEQWQQLTAEDGTVWRSRAYHGKLGKYSDMAVGAFNKVLNLVRGAETFDIALVTCAYIAMFYTLFNLFARMRAVGSKVWLGLSTLVSSFFAFLFALYITTRVLDLSIPFLSLSEGIPFFVAVVGFNNKILLAEKVLQNQLNAQSSKNDAPTVLYQALREQGPLLLRDHLFMITAFLGCSFYASYLDGLKNFCILAALILAFDILTTSTFLSAILSLKLEINQIHRSTLLREQLEDDGLTETTVDDVLKSNSLAGTKTFTDAPSTLVTVAKVAGVSVFFGLHFYGFGSAWLSDLSAGNETNDTFTLYDAVADQIPIGSNGTLVTLFPTRFFLPEKLSTQIEAVVLSFIGLISTAARDKYISKFILFAFAVSASINVYLLNVARIHTTRLEDAIELKKPKKKASKTAVSVPKAVVVKDSETTKSSEILHSSSESESEQSSRPLEQVIELYKDGKVKTLVDDEVVSLVTAGKLPLYALEKQLGDNLRAVAIRRKAISDLADAPVLRSNKLPYLHYDYDRVFGACCENVIGYMPLPVGVAGPLIIDGKPYHIPMATTEGCLVASAMRGCKAINLGGGVTTVLTKDGMTRGPCVKFPSLKRAGQCKLWLDSDEGQEEMKKAFNSTSRFARLQHLQTALAGDLLFIRFRTVTGDAMGMNMISKGVEYALKQMTEVFGWDDMMVVSVSGNYCTDKKPAAVNWINGRGKSVVAEASIPKDAVVKVLKSSVKAVVDVNVNKNLIGSAMAGSVGGFNAQAANMVTAVYLALGQDPAQNVESSNCITLMTETEDGDLKVSVSMPSIEVGTIGGGTILDPQGSMLELLGVRGPADVPGENARQLAKIVASIVLSGELSLVSALAAGHLVQSHMQHNRAAAKK