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HI_0858

Gene
HI_0858
Protein
5-formyltetrahydrofolate cyclo-ligase
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
187 amino acids
Function
Involved in the removal of 5-formyltetrahydrofolate. In vitro, it is a potent inhibitor of various folate-dependent enzymes in the C1 metabolism network and in vivo it might function as a folate storage. 5-formyltetrahydrofolate is also used as an antifolate rescue agent in cancer chemotherapy. Catalyzes the irreversible ATP-dependent transformation of 5-formyltetrahydrofolate (5-CHO-THF) to form 5,10-methenyltetrahydrofolate (5,10-CH=THF). The reverse reaction is catalyzed by the serine hydroxymethyltransferase GlyA (SHMT) (By similarity).
Similarity
Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
Mass
21.821 kDa
Sequence
MNTQKRQQIRTEIRKIRANLTALQQHQAEQSVTQHALNLIEQRQAKNIALYFSFDGEISTKALIQSLWMQNKNVYLPVLHPFTKHYLLFLRYLPDTPMKQNQFGIWEPKLNVQNVLPLNELDILFTPLVAFDKKGNRLGMGGGFYDRTLQNWQNKSFIPVGLAYQCQQVENLPTEHWDVPLFDILVG