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HIVEP3

Gene
HIVEP3
Protein
Transcription factor HIVEP3
Organism
Homo sapiens
Length
2406 amino acids
Function
Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.
Mass
259.465 kDa
Sequence
MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAATQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGVPKVFVPRPSQVSLKPTEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPGEEFEEPTEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHKPEDTHTIKQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRSHSMPSAACTISTPHHPFRGSYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPKESELTKKTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTSPEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKSLGDEEEPPAFESTKSQFGSPGPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEISVIQHTSSFEKSDSLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLGTHMLTVPSHHPHAREMRRSASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVAPPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPSAKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSSLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQIKTSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSSATVALPKFEEPPSKGTTVCGADVHEVGPGPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRRELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEALKEYPQPSGKPHRRGLTPLSVKKEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEERRGEPEEDAPASQRGEPARIKIFEGGYKSNEEYVYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLFQDSEGREGSEAVEEHQFSDLEDSDSDSDLDEDEDEDEEESQDELSRPSSEAPPPGPPHALRADSSPILGPQPPDAPASGTEATRGSSVSEAERLTASSCSMSSQSMPGLPWLGPAPLGSVEKDTGSALSYKPVSPRRPWSPSKEAGSRPPLARKHSLTKNDSSPQRCSPAREPQASAPSPPGLHVDPGRGMGALPCGSPRLQLSPLTLCPLGRELAPRAHVLSKLEGTTDPGLPRYSPTRRWSPGQAESPPRSAPPGKWALAGPGSPSAGEHGPGLGLDPRVLFPPAPLPHKLLSRSPETCASPWQKAESRSPSCSPGPAHPLSSRPFSALHDFHGHILARTEENIFSHLPLHSQHLTRAPCPLIPIGGIQMVQARPGAHPTLLPGPTAAWVSGFSGGGSDLTGAREAQERGRWSPTESSSASVSPVAKVSKFTLSSELEGGDYPKERERTGGGPGRPPDWTPHGTGAPAEPTPTHSPCTPPDTLPRPPQGRRAAQSWSPRLESPRAPTNPEPSATPPLDRSSSVGCLAEASARFPARTRNLSGEPRTRQDSPKPSGSGEPRAHPHQPEDRVPPNA

Gene
Hivep3
Protein
Transcription factor HIVEP3
Organism
Mus musculus
Length
2348 amino acids
Function
Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.
Mass
253.413 kDa
Sequence
MDPDQSIKGTKKADGSPRKRLTKGEAIQTSVSSSAPYPGSGTTAPSESATQELLATQPFSGPSQEKTGQQQKPARRPSIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASILPPEELPGIPKVFVPRPSQVSLKPAEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGSSSEMYPPGLEMERIPGEEFEEPTEGESTDSEEETGAASGPSTDVLPKPKHPLLSSSLYSSGSHGSSQERCSLSQSSTGPSLEDPAPFAEASSEHPLSHKPEDTHTIKQKLALRLSERKKLIEEQTFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTSMLASTSTQPLLPLSSEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLTRRSSVESPKSSLYRDSLSSHGEKTKQEQSLLSLQHPPSSTHPVPLLRSHSMPSAACTISTHHHTFRGSYSFDDHVADPEVPSRNTPVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDPTSKPSDEPEPKESDLTKKTKKGFKTKGANYECTICGARYKKRDNYEAHKKYYCSELQITKAHSVGAHEVEKTQAEPEPWSQMMHYKLGATLELTPLRKRRKEKSLGDEEEPPAFGSPGPSETAHNRPLGSTKSPAEASKSAPSLEGPTSFQPRTPKPGAGSEPGKERRTMSKEISVIQHTSSFEKSDPPEQPSGLEEDKPPAQFSSPPPAPHGRSAHSLQPRLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESSISLSGSSRSASFDREDHGKAEAPGPFSDTRSKTLGSHMLTVPSHHPHAREMRRSASEQSPNVPHSSHMTETRSKSFDYGSLSPTGPSLAVPAAPPPPAAPPERRKCFLVRQASLNRPPEAELEAVPKGKQESSEEPAASKPSTKSSVPQISVGTTQGGPSGGKSQMQDRPPLGSSPPYTEALQVFQPLGTQLPPPASLFSLQQLLPQEQEQSSEFFPTQAMAGLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHAADIPFQQPPSFLPMPCPAPSTLSGYFLPLQSQFALQLPGEIESHLPPVKTSLPPLATGPPGPSSSTEYSSDIQLPPVTPQATSPAPTSAPPLALPACPDAMVSLVVPVRIQTHMPSYGSAMYTTLSQILVTQSPGSPASTALTKYEEPSSKSMTVCEADVYEAEPGPSSISKEQNRGYQTPYLRVPERKGTSLSSEGILSLEGCSSTASGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVSTCSVVLTSTEDRKKTEKPHVGGQGRSRREAETLSSLSSDVSDPKELSPLSHSTLSHGTAPGSEALKEYAQPSSKAHRRGLPPMSVKKEDPKEQTDLPPLAPPSSLPLSDTSPKPAKLQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSNSRKPRMTEVHLPSLVSPESQKDPARVEKEEKQGKAEEGTPTSKRGEPARVKIFEGGYKSNEEYIYVRGRGRGRYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLHQDSEGQEGAEAVEEHQFSDLEDSDSDSDLDEDEEEEEEEEESQDELSGPCSEAAPPCLPPTLQENSSPVEGPQAPDSTSDEVPQGSSISEATHLTASSCSTPSRGTQGLPRLGLAPLEKDMSSAPSPKATSPRRPWSPSKEAGSRPSLTRKHSLTKNDSSPQQCSPAREAQASVTSTPGPQMGPGRDLGPHLCGSPRLELSCLTPYPIGREAPAGLERATDTGTPRYSPTRRWSLGQAESPPQTVLPGKWALAGPCSPSADKSGLGLGPVPRALLQPVPLPHTLLSRSPETCTSAWRKTESRSPSAGPAPLFPRPFSAPHDFHGHLPSRSEENLFSHLPLHSQLLSRAPCPLIPIGGIQMVQARPGAQPTVLPGPCAAWVSGFSGGGSDLTGAREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTGRGPGRPPDWEPHRAEAPPGPMGTHSPCSPQLPQGHQVAPSWRGLLGSPHTLANLKASSFPPLDRSSSMDCLAETSTYSPPRSRNLSGEPRTRQGSPELLGRGELRTPLFLPKGSGPPSI