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HFE

Gene
Hfe
Protein
Hereditary hemochromatosis protein homolog
Organism
Rattus norvegicus
Length
360 amino acids
Function
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Similarity
Belongs to the MHC class I family.
Mass
40.988 kDa
Sequence
MDRSAGLPVRLLLLLLLLLLWSVAPQALRPGSHSLRYLFMGASKPDLGLPFFEALGYVDDQLFVSYNHESRRAEPRAPWILGQTSSQLWLQLSQSLKGWDYMFIVDFWTIMGNYNHSKVTKLRVVPESHILQVILGCEVHEDNSTSGFWKYGYDGQDHLEFCPKTLNWSAAEPRAWATKMEWEEHRIRARQSRDYLQRDCPQQLKQVLELQRGVLGQQVPTLVKVTRHWASTGTSLRCQALNFFPQNITMRWLKDSQPLDAKDVNPENVLPNGDGTYQGWLTLAVAPGEETRFSCQVEHPGLDQPLTATWEPSRSQDMIIGIISGITICAIFFVGILILVLRKRKVSGGTMGDYVLTECE
Protein
Hereditary hemochromatosis protein homolog: Hfe

Gene
Hfe
Protein
Hereditary hemochromatosis protein homolog
Organism
Mus musculus
Length
359 amino acids
Function
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Similarity
Belongs to the MHC class I family.
Mass
40.534 kDa
Sequence
MSLSAGLPVRPLLLLLLLLWSVAPQALPPRSHSLRYLFMGASEPDLGLPLFEARGYVDDQLFVSYNHESRRAEPRAPWILEQTSSQLWLHLSQSLKGWDYMFIVDFWTIMGNYNHSKVTKLGVVSESHILQVVLGCEVHEDNSTSGFWRYGYDGQDHLEFCPKTLNWSAAEPGAWATKVEWDEHKIRAKQNRDYLEKDCPEQLKRLLELGRGVLGQQVPTLVKVTRHWASTGTSLRCQALDFFPQNITMRWLKDNQPLDAKDVNPEKVLPNGDETYQGWLTLAVAPGDETRFTCQVEHPGLDQPLTASWEPLQSQAMIIGIISGVTVCAIFLVGILFLILRKRKASGGTMGGYVLTDCE
Protein
Hereditary hemochromatosis protein homolog: Hfe

Gene
HFE
Protein
Hereditary hemochromatosis protein homolog
Organism
Ceratotherium simum
Length
348 amino acids
Function
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Similarity
Belongs to the MHC class I family.
Mass
39.822 kDa
Sequence
MGPRARPALFFLILLRTVAAQGRPPRSHSLRYLFMGASERDHGLPLFEALGYVDDELFVAYNHESRRAESRAQWVLGEAHSQLWLQLSQSLKGWDHMFIVDFWTIMDNHNHSKESHTLQVILGCEVQEDNSTRGFWKYGYDGQDHLEFCPETLDWRAAESRALTTKLEWEVNKIRAKQNRAYLERDCPEQLQWLLELGRGVLDQQVPPLVKVTHHVASAVTTLRCQALNFYPQNITMRWLKDRKPMDVKDAESKDVLPSGDGTYQSWEALAVPPGEEQRYTCQVEHPGLDQPLTATWEPSLSNTLVTGVISGIAVCVIIFFIGILFRILRKRQASRGAMGDYVLGECE
Protein
Hereditary hemochromatosis protein homolog: HFE

Gene
HFE
Protein
Hereditary hemochromatosis protein homolog
Organism
Diceros bicornis
Length
348 amino acids
Function
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Similarity
Belongs to the MHC class I family.
Mass
39.818 kDa
Sequence
MGPRARPALFFLILLRTVAAQGRPPRSHSLRYLFMGASERDHGLPLFEALGYVDDELFVAYNHESRRAESRAQWVLGEAHSQLWLQLTQSLKGWDHMFIVDFWTIMDNHNHSKESHTLQVILGCEVQEDNSTRGFWKYGYDGQDHLEFCPETLDWRAAESRALTTKLEWEVNKIRAKQNRAYLERDCPEQLQWLLELGRGVLDQQVPPLVKVTHHVASAVTTLRCQALNFYPQNITMRWLKDRKPVDVKDAESKDVLPSGDGTYQSWEALAVPPGEEQRYTCQVEHPGLDQPLTATWEPSLSNTLVTGVISGIAVCVIIFFIGILFRILRKRQASRGAMGDYVLAECE
Protein
Hereditary hemochromatosis protein homolog: HFE

Gene
HFE
Protein
Hereditary hemochromatosis protein homolog
Organism
Dicerorhinus sumatrensis
Length
348 amino acids
Function
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Similarity
Belongs to the MHC class I family.
Mass
39.74 kDa
Sequence
MGPRARPALFFLILLRTVAAQGRPPRSHSLRYLFMGASERDHGLPLFEALGYVDDELFVAYNHESRRAESRAQWVLGEAHSQLWLQLSQSLKGWDHMFIVDFWTIMDNHNHSKESHTLQVILGCEVQEDNSTRGFWKYGYDGQDHLEFCPETLDWRAAESRALTTKLEWEVNKIRAKQNRAYLERDCPEQLQWLLELGRGVLDQQVPPLVKVTHHVASAVTTLRCQALNFYPQNITMRWLKDRKPVDVKDAESKDVLPSGDGTYQSWVALAVPPGEEQRYTCQVEHPGLDQPLTATWEPSLSNTLVTGVISGIAVCVIIFLIGILFRILRKRQASRGAMGDYVLAECE
Protein
Hereditary hemochromatosis protein homolog: HFE

Gene
HFE
Protein
Hereditary hemochromatosis protein
Organism
Homo sapiens
Length
348 amino acids
Function
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Similarity
Belongs to the MHC class I family.
Mass
40.108 kDa
Sequence
MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVTSSVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRGAMGHYVLAERE
Protein
Hereditary hemochromatosis protein: HFE

Gene
HFE
Protein
Hereditary hemochromatosis protein homolog
Organism
Pan troglodytes
Length
348 amino acids
Function
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Similarity
Belongs to the MHC class I family.
Mass
40.108 kDa
Sequence
MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVTSSVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRGAMGHYVLAERE
Protein
Hereditary hemochromatosis protein homolog: HFE

Gene
HFE
Protein
Hereditary hemochromatosis protein homolog
Organism
Rhinoceros unicornis
Length
348 amino acids
Function
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Similarity
Belongs to the MHC class I family.
Mass
39.743 kDa
Sequence
MGPRARPALFFLILLRTVAAQGRPPRSHSLRYLFMGASERDHGLPLFEALGYVDDELFVAYNHESRRAESRAQWVLGEAHSQLWLQLSQSLKGWDHMFIVDFWTIMDNHNHSKESHTLQVILGCEVQEDNSTRGFWMYGYDGQDHLEFCPETLDWRAAESRALTTKLEWEVNKIRAKQNRAYLERDCPEQLQWLLELGRGVLDQQVPPLVKVTHHVASAVTTLRCQALNFYPQNITMRWLKDRKPVDVKDAESKDVLPSGDGTYQSWVALAVPPGEEQRYTCQVEHPGLDQPLTATWEPSLSNTLVTGVISGIAVCVIIFLIGILFRILRKRQASRGAMGDYVLAECE
Protein
Hereditary hemochromatosis protein homolog: HFE