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HES2

Gene
hes2
Protein
Transcription factor HES-2
Organism
Xenopus laevis
Length
191 amino acids
Function
Transcriptional repressor. Essential in the retina to govern glial versus neuronal differentiation. Promotes gliogenesis through the inhibition of neuronal differentiation by at least two distinct mechanisms; represses proneural gene transcription, and also physically interacts with proneural proteins, including neurod1.
Mass
21.823 kDa
Sequence
MAPNVALADSMHNYQPKPGKRNQEASELRKTLKPLMEKRRRARINESLNQLKTLILPLIGKDNSRYSKLEKADILEMTVRFLRDIPPVQAQNQADRYKEGYRACVERLSAILGKSHVLTGEASNRLLEYLQRSPELCSSDCNHPPKPQRPRIVLQVSPRTSQFGSPLQNQPSSHRPAPCPPQLNSSIWRPW

Gene
HES2
Protein
Transcription factor HES-2
Organism
Homo sapiens
Length
173 amino acids
Function
Transcriptional repressor of genes that require a bHLH protein for their transcription.
Mass
18.47 kDa
Sequence
MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPASSWPTAAPLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSSGPSAPAPAPASAPEPASAPVPSPPSPPCGPGLWRPW

Gene
Hes2
Protein
Transcription factor HES-2
Organism
Mus musculus
Length
157 amino acids
Function
Transcriptional repressor of genes that require a bHLH protein for their transcription.
Mass
17.259 kDa
Sequence
MRLPRRVEDAAELRKNLKPLLEKRRRARINESLSQLKGLVLPLLGAETSRSSKLEKADILEMTVRFLQEQPATLYSSAAPGPLNSYLEGYRACLARLARVLPACSVLEPAVSARLLEHLRQRTVSDDSPSLTLPPAPAPAPSPPVPPPGSSGLWRPW

Gene
Hes2
Protein
Transcription factor HES-2
Organism
Rattus norvegicus
Length
157 amino acids
Function
Transcriptional repressor of genes that require a bHLH protein for their transcription.
Mass
17.028 kDa
Sequence
MRLPRGVGDAAELRKSLKPLLEKRRRARINESLSQLKGLVLPLLGAETSRYSKLEKADILEMTVRFLREQPASVCSTEAPGSLDSYLEGYRACLARLARVLPACSVLEPAVSARLLEHLRQRTVSGGPPSLTPASASAPAPSPPVPPPSSLGLWRPW