Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Required for appropriate cellular patterning in the root epidermis. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
Sequence
MLLKFEASSELRLVDPSVSLTVLRKIRLSHLPDMTMTSESSGKKCGEGDGKVAGKSQRKVGLVYDETMCKHDTPNGKVDVECPDRIRVIWEKLQLAGVTQRCVVLGGSKAEDKHLKLVHTKKHVNLVKSISTKKKDSRRNKIASQLDSIYLNGGSSEAAYLAAGSVVKVAEKVAEGELDCGFAIVRPPGHHAESDEAMGFCLFNNVAVAASFLLNERPDLDVKKILIVDWDIHHGNGTQKMFWKDSRVLIFSVHRHDHGSFYPFGDDGDFNMVGEGPGEGFNINVPWEQGGCGDADYLAVWNHILIPVTKEFKPDIILLSAGFDAAIGDPLGGCCVTPYGYSVMLKKLMEFAHGKIVLALEGGYNLESLGKSSLACVQVLLEDKQIHGSSETYPLESTRRVIQAVRERLCTYWPSLDASMASNENLKNPSAERNSADALLREVEELKSLMAARDGELEARRKELKAKNKELEANEKELEAGLMLIRAREDVICGLHAKIESLQQERDEAVAKAERIDKELQEDRARSQEFKEDTEFCLSTLRREKELAIMAKNKDLEAKEKELEARLMLVHAREDKIHAKIERLQQERDEAVAKAERIDKELQEDRSRSRVGNGSFAFSQEFYEDMDLDELEPLSPEFNEDMDSEELEPFQVIKKNMERSHKKFIKDMECIKFIASERARVL