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H2AX

Gene
H2AX
Protein
Histone H2AX
Organism
Dictyostelium discoideum
Length
154 amino acids
Function
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Phosphorylation of H2AX seems to be performed by atr1 and/or possibly dnapkcs, as ATM ortholog is absent in the genome of this organism.
Similarity
Belongs to the histone H2A family.
Mass
16.824 kDa
Sequence
MSETKPASSKPAAAAKPKKVIPRVSRTGEPKSKPESRSARAGITFPVSRVDRLLREGRFAPRVESTAPVYLAAVLEYLVFEILELAHNTCSISKKTRITPQHINWAVGNDLELNSLFQHVTIAYGGVLPTPQQSTGEKKKKPSKKAAEGSSQIY