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Gpha2

Gene
Gpha2
Protein
Glycoprotein hormone alpha-2
Organism
Rattus norvegicus
Length
130 amino acids
Function
Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.
Similarity
Belongs to the glycoprotein hormones subunit alpha family.
Mass
14.199 kDa
Sequence
MPMAPRVLLFCLLGLAVTEGHGLEAAVPIPGCHLHPFNVTVRSDRHGTCQGSHVAQACVGHCESSAFPSRYSVLVASGYRHNITSVSQCCTISSLKKVRVWLHCVGNQRGELEIFTARACQCDMCRLSRY

Gene
GPHA2
Protein
Glycoprotein hormone alpha-2
Organism
Homo sapiens
Length
129 amino acids
Function
Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production (PubMed:12045258). Plays a central role in controlling thyroid cell metabolism (PubMed:12045258).
Similarity
Belongs to the glycoprotein hormones subunit alpha family.
Mass
14.163 kDa
Sequence
MPMASPQTLVLYLLVLAVTEAWGQEAVIPGCHLHPFNVTVRSDRQGTCQGSHVAQACVGHCESSAFPSRYSVLVASGYRHNITSVSQCCTISGLKKVKVQLQCVGSRREELEIFTARACQCDMCRLSRY

Gene
Gpha2
Protein
Glycoprotein hormone alpha-2
Organism
Mus musculus
Length
128 amino acids
Function
Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.
Similarity
Belongs to the glycoprotein hormones subunit alpha family.
Mass
14.03 kDa
Sequence
MPMAPRVLLLCLLGLAVTEGHSPETAIPGCHLHPFNVTVRSDRLGTCQGSHVAQACVGHCESSAFPSRYSVLVASGYRHNITSSSQCCTISSLRKVRVWLQCVGNQRGELEIFTARACQCDMCRFSRY