GUCY1A2

Guanylate cyclase soluble subunit alpha-2

732 amino acids

Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

81.75 kDa

MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNCSCLTFLIKECENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKFEDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYNIGTMFLRETSL

Gucy1a2

Guanylate cyclase soluble subunit alpha-2

730 amino acids

Has guanylyl cyclase on binding to the beta-1 subunit.

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

81.787 kDa

MSRRKISSESFSSLGSDYLETSPEEEGECPLSKLCWNGSRSPPGPPGSRAAAMAATPVPAASVAAAAAAVAAGSKRAQRRRRVNLDSLGESISLLTAPSPQTIHMTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSSADHSNKEEIEDVSGILRCTANVLGLKFQEIQERFGEEFFKICFDENERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLKLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQIENEKFCSDGSTPSNYSCLTFLIKECETTQITKNIPQGTSQIPTDLRISINTFCRTFPFHLMFDPNMVVLQLGEGLRKQLRCDNHKVLKFEDCFEIVSPKVNATFDRVLLRLSTPFVIRTKPEASGTDNEDKVMEIKGQMIHVPESNAILFLGSPCVDKLDELIGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLEKTHQALEEEKKKTVDLLYSIFPGDVAQQLWQRQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINISPTTYQLLKREDSFTFIPRSREELPDNFPKEIPGVCYFLELRTGPKPPKPSLSSSRIKKVSYNIGTMFLRETSL