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GUCA1B

Gene
GUCA1B
Protein
Guanylyl cyclase-activating protein 2
Organism
Bos taurus
Length
204 amino acids
Function
Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.
Mass
23.728 kDa
Sequence
MGQQFSWEEAEENGAVGAADAAQLQEWYKKFLEECPSGTLFMHEFKRFFKVPDNEEATQYVEAMFRAFDTNGDNTIDFLEYVAALNLVLRGTLEHKLKWTFKIYDKDRNGCIDRQELLDIVESIYKLKKACSVEVEAEQQGKLLTPEEVVDRIFLLVDENGDGQLSLNEFVEGARRDKWVMKMLQMDLNPSSWISQQRRKSAMF

Gene
Guca1b
Protein
Guanylyl cyclase-activating protein 2
Organism
Mus musculus
Length
201 amino acids
Function
Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).
Mass
23.52 kDa
Sequence
MGQQLSWEEAEAAGEMDVAELQEWYKKFVVECPSGTLFMHEFKRFFKVTGNEEASQYVESMFRAFDKNGDNTIDFLEYVAALNLVLRGSLEHKLKWTFKIYDKDRNGCIDRLELLDIVEAIYKLKKACRAELDLEHQGQLLTPEEVVDRIFLLVDENGDGQLSLTEFIEGARRDKWVMKMLQMDINPGCWITQQRRRSAMF

Gene
GUCA1B
Protein
Guanylyl cyclase-activating protein 2
Organism
Homo sapiens
Length
200 amino acids
Function
Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.
Mass
23.42 kDa
Sequence
MGQEFSWEEAEAAGEIDVAELQEWYKKFVMECPSGTLFMHEFKRFFKVTDDEEASQYVEGMFRAFDKNGDNTIDFLEYVAALNLVLRGTLEHKLKWTFKIYDKDGNGCIDRLELLNIVEGIYQLKKACRRELQTEQGQLLTPEEVVDRIFLLVDENGDGQLSLNEFVEGARRDKWVMKMLQMDMNPSSWLAQQRRKSAMF

Gene
GUCA1B
Protein
Guanylyl cyclase-activating protein 2
Organism
Gallus gallus
Length
198 amino acids
Function
Stimulates synthesis of cGMP in photoreceptors. Thought to mediate Ca(2+)-sensitive regulation of guanylyl cyclase (GC), a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).
Mass
23.128 kDa
Sequence
MGQQFTNAEGEQTEIDVAELQEWYKKFVVECPSGTLFMHEFKRFFGVQDNHEAAEYIENMFRAFDKNGDNTIDFLEYVAALNLVLRGKLEHKLRWTFKVYDKDGNGCIDKPELLEIVESIYKLKKVCRSEVEERTPLLTPEEVVDRIFQLVDENGDGQLSLDEFIDGARKDKWVMKMLQMDVNPGGWISEQRRKSALF

Gene
GUCA1B
Protein
Guanylyl cyclase-activating protein 2
Organism
Lithobates pipiens
Length
197 amino acids
Function
Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).
Mass
23.019 kDa
Sequence
MGQHLSEESNKVEIDVAELQEWYKKFVVECPSGTLFMHEFKRFFGVQDNQEAADYVEHMFRAFDKNGDNTIDFLEYVAALNLVLRGKLEHKLKWTFKVYDRDGNGCIDKTELLEIVESIYNLKKVCRQGQDDRIPLLSPEQVVDRIFQLVDENGDGQLSLDEFIDGARKDKWVMKMLQMDVSPGSWINEQRRKSALF