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GSTZ1

Gene
GstZ1
Protein
Probable maleylacetoacetate isomerase 1
Organism
Drosophila melanogaster
Length
246 amino acids
Function
Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Possesses low glutathione thioltransferase activity toward 4-hydroxynonenal (4-HNE). Has no glutathione thioltransferase activity with adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED).
Similarity
Belongs to the GST superfamily. Zeta family.
Mass
27.89 kDa
Sequence
MASATQLTHRGIHLAGLYRSSWSKPLFRHLATKPILYSYWPSSCSWRVRVALAIKKIDYDIKPTSLLKTVSGHAYTDEYREVNPMQKVPSLKIDGHTLCDSVAIIHYLEETRPQPALLPQDPVKRAKIREIVELICSGIQPLQNVSVLDHIGKDQSLQWAQHWISRGFQGLEKVLSHSAGKFCVGDELSMADICLVPQVRNARRYKADLTPYPTIVRLNQELQELDVFKATHPSTQPDCPPEFAKK

Gene
GSTZ1
Protein
Glutathione S-transferase Z1
Organism
Arabidopsis thaliana
Length
221 amino acids
Function
Acts a maleylacetone isomerase. Also catalyzes the glutathione-dependent dehalogenation of dichloroacetic acid to glyoxylic acid. In vitro, possesses glutathione peroxidase activity toward cumene hydroperoxide and linoleic acid-13-hydroperoxide.
Similarity
Belongs to the GST superfamily. Zeta family.
Mass
24.888 kDa
Sequence
MANSGEEKLKLYSYWRSSCAHRVRIALALKGLDYEYIPVNLLKGDQFDSDFKKINPMGTVPALVDGDVVINDSFAIIMYLDEKYPEPPLLPRDLHKRAVNYQAMSIVLSGIQPHQNLAVIRYIEEKINVEEKTAWVNNAITKGFTALEKLLVNCAGKHATGDEIYLADLFLAPQIHGAINRFQINMEPYPTLAKCYESYNELPAFQNALPEKQPDAPSSTI

Gene
GSTZ1
Protein
Maleylacetoacetate isomerase
Organism
Homo sapiens
Length
216 amino acids
Function
Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.
Similarity
Belongs to the GST superfamily. Zeta family.
Mass
24.212 kDa
Sequence
MQAGKPILYSYFRSSCSWRVRIALALKGIDYKTVPINLIKDRGQQFSKDFQALNPMKQVPTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA

Gene
Gstz1
Protein
Maleylacetoacetate isomerase
Organism
Mus musculus
Length
216 amino acids
Function
Probable bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with t-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid (By similarity).
Similarity
Belongs to the GST superfamily. Zeta family.
Mass
24.275 kDa
Sequence
MQAGKPILYSYFRSSCSWRVRIALALKGIDYEIVPINLIKDGGQQFTEEFQTLNPMKQVPALKIDGITIVQSLAIMEYLEETRPIPRLLPQDPQKRAIVRMISDLIASGIQPLQNLSVLKQVGQENQMQWAQKVITSGFNALEKILQSTAGKYCVGDEVSMADVCLVPQVANAERFKVDLSPYPTISHINKELLALEVFQVSHPRRQPDTPAELRT

Gene
Gstz1
Protein
Maleylacetoacetate isomerase
Organism
Rattus norvegicus
Length
216 amino acids
Function
Probable bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with t-butyl and cumene hydroperoxides (By similarity). Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.
Similarity
Belongs to the GST superfamily. Zeta family.
Mass
23.961 kDa
Sequence
MQAGKPVLYSYFRSSCSWRVRIALALKGIDYEIVPINLIKDGGQQFSEEFQTLNPMKQVPALKIDGITIGQSLAILEYLEETRPIPRLLPQDPQKRAIVRMISDLIASGIQPLQNLSVLKQVGQENQMPWAQKAITSGFNALEKILQSTAGKYCVGDEVSMADVCLAPQVANAERFKVDLSPYPTISHINKALLALEAFQVSHPCRQPDTPAELRT

Gene
GSTZ1
Protein
Glutathione S-transferase
Organism
Triticum aestivum
Length
213 amino acids
Function
Has a glutathione transferase activity with ethacrynic acid and nitrophenyl acetate. Has low glutathione peroxidase activity with cumene hydroperoxide.
Similarity
Belongs to the GST superfamily. Zeta family.
Mass
23.752 kDa
Sequence
MATAKPILYGAWISSCSHRVRIALNLKGVDYEYKAVNPRTDPDYEKINPIKYIPALVDGDFVLSDSLAIMLYLEDKYPQHPLVPKDIKTKGLDLQIANIVCSSIQPLQGYGVIGLHEGRLSPDESLEVVQRYIDKGFRAIEKLLDGCDSKYCVGDEVHLGDVCLAPQIHAAINRFQIDMTKYPILSRLHDAYMKIPAFQAALPQNQPDAPSAK