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GRK4

Gene
GRK4
Protein
G protein-coupled receptor kinase 4
Organism
Homo sapiens
Length
578 amino acids
Function
Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
Similarity
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Mass
66.583 kDa
Sequence
MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC

Gene
GRK4
Protein
G protein-coupled receptor kinase 4
Organism
Homo sapiens
Length
578 amino acids
Function
Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
Similarity
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Mass
66.583 kDa
Sequence
MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC

Gene
Grk4
Protein
G protein-coupled receptor kinase 4
Organism
Rattus norvegicus
Length
575 amino acids
Function
Specifically phosphorylates the activated forms of G protein-coupled receptors. Plays an important role in the regulation of renal sodium handling and blood pressure.
Similarity
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Mass
66.788 kDa
Sequence
MELENFMANTLLLKARQGFTKKTGRSKKWRELLKLPPVSMCSDLRHSIEKDFSSLCDQQPIGRLLFRQFCNTKPDLKRCIEFLDAAAEYEVTIEEEQREFGLSIYSRFFKENSEVSLPQIPPDLVKECKCNLKQSSPSQNVFQDCAGVIYKYLSEKPFEEYQESTYYNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGNPGFEEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDHGHIRISDLGLALEIPEGEMVRGRVGTVGYMAPEIISHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREEMERRVKTETEEYSERFSENAKSICSMLLTKDPSKRLGCQSDGASAVKQHPIFKDINFSRLEANMLDPPFCPDPEAIYCKDILDIGQFSVVKGVNLDTNDEIFYTQFATGCVTIPWQNEMIESGCFKDLNEYEDKGLSPLEKHKICSCILRPKRNFFHRLFRRAACLNIAHSEEREPTEH

Gene
Grk4
Protein
G protein-coupled receptor kinase 4
Organism
Rattus norvegicus
Length
575 amino acids
Function
Specifically phosphorylates the activated forms of G protein-coupled receptors. Plays an important role in the regulation of renal sodium handling and blood pressure.
Similarity
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Mass
66.788 kDa
Sequence
MELENFMANTLLLKARQGFTKKTGRSKKWRELLKLPPVSMCSDLRHSIEKDFSSLCDQQPIGRLLFRQFCNTKPDLKRCIEFLDAAAEYEVTIEEEQREFGLSIYSRFFKENSEVSLPQIPPDLVKECKCNLKQSSPSQNVFQDCAGVIYKYLSEKPFEEYQESTYYNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGNPGFEEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDHGHIRISDLGLALEIPEGEMVRGRVGTVGYMAPEIISHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREEMERRVKTETEEYSERFSENAKSICSMLLTKDPSKRLGCQSDGASAVKQHPIFKDINFSRLEANMLDPPFCPDPEAIYCKDILDIGQFSVVKGVNLDTNDEIFYTQFATGCVTIPWQNEMIESGCFKDLNEYEDKGLSPLEKHKICSCILRPKRNFFHRLFRRAACLNIAHSEEREPTEH

Gene
Grk4
Protein
G protein-coupled receptor kinase 4
Organism
Mus musculus
Length
574 amino acids
Function
Specifically phosphorylates the activated forms of G protein-coupled receptors.
Similarity
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Mass
66.928 kDa
Sequence
MELENFVANNLLLKARLGFNKQTGRSKKWRELLKFPPVSMCTELRWSIEKDFSSLCDKQPIGRLLFRQFCDTKPDLKRCIEFLDAVAEYEVTIEEEQREFGLAIFSRFFKEKSEVPLPEIPPDIVKECKWNLKQNSPSQNVFEECAGIVCKYLSETPFEEYQESTYFNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGDPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPEGEMVRGRVGTVGYMAPEIINHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREELERRVKNETEEYSERFSEDAKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIFKDINFSRLEANMLDPPFIPDPQAIYCRNILDIGQFSVVKGVNLDTNDEIFYAEFATGSVTIPWQNEMIESGCFKDLNENEDDLSSLEKYKMCSSILRPKRNFFRRLFRRTGCLNIALSEEREPTEH

Gene
Grk4
Protein
G protein-coupled receptor kinase 4
Organism
Mus musculus
Length
574 amino acids
Function
Specifically phosphorylates the activated forms of G protein-coupled receptors.
Similarity
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Mass
66.928 kDa
Sequence
MELENFVANNLLLKARLGFNKQTGRSKKWRELLKFPPVSMCTELRWSIEKDFSSLCDKQPIGRLLFRQFCDTKPDLKRCIEFLDAVAEYEVTIEEEQREFGLAIFSRFFKEKSEVPLPEIPPDIVKECKWNLKQNSPSQNVFEECAGIVCKYLSETPFEEYQESTYFNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGDPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPEGEMVRGRVGTVGYMAPEIINHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREELERRVKNETEEYSERFSEDAKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIFKDINFSRLEANMLDPPFIPDPQAIYCRNILDIGQFSVVKGVNLDTNDEIFYAEFATGSVTIPWQNEMIESGCFKDLNENEDDLSSLEKYKMCSSILRPKRNFFRRLFRRTGCLNIALSEEREPTEH