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GRHL1

Gene
GRHL1
Protein
Grainyhead-like protein 1 homolog
Organism
Homo sapiens
Length
618 amino acids
Function
Isoform 2: May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed.
Similarity
Belongs to the grh/CP2 family. Grainyhead subfamily.
Mass
70.113 kDa
Sequence
MTQEYDNKRPVLVLQNEALYPQRRSYTSEDEAWKSFLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRERRSSTAKPEVEHPEPDHSKRNSIPIVTEQPLISAGENRVQVLKNVPFNIVLPHGNQLGIDKRGHLTAPDTTVTVSIATMPTHSIKTETQPHGFAVGIPPAVYHPEPTERVVVFDRNLNTDQFSSGAQAPNAQRRTPDSTFSETFKEGVQEVFFPSDLSLRMPGMNSEDYVFDSVSGNNFEYTLEASKSLRQKPGDSTMTYLNKGQFYPITLKEVSSSEGIHHPISKVRSVIMVVFAEDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEIAYNAISFTWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQVDTYSYNNRSNKPVHRAYCQIKVFCDKGAERKIRDEERKQSKRKVSDVKVPLLPSHKRMDITVFKPFIDLDTQPVLFIPDVHFANLQRGTHVLPIASEELEGEGSVLKRGPYGTEDDFAVPPSTKLARIEEPKRVLLYVRKESEEVFDALMLKTPSLKGLMEAISDKYDVPHDKIGKIFKKCKKGILVNMDDNIVKHYSNEDTFQLQIEEAGGSYKLTLTEI

Gene
Grhl1
Protein
Grainyhead-like protein 1 homolog
Organism
Mus musculus
Length
618 amino acids
Function
Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:18288204, PubMed:21081122). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier (PubMed:18288204, PubMed:24586629). There is no genetic interaction with GRHL3 no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (PubMed:21081122).
Similarity
Belongs to the grh/CP2 family. Grainyhead subfamily.
Mass
70.176 kDa
Sequence
MTQEYDNKRPVLVLQNEALYPQRRSYTSEDEAWKSFLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRERRSSAVKPEGEHPEPEHSKRNSIPNVTEQPLISAGENRVQVLKNVPFNIVLPHSNQLGIDKRGHLTAPDTTVTVSIATMPTHSIKTEIQPHGFAVGIPPAVYHSEPTERVVVFDRSLSTDQFSSGTQPPNAQRRTPDSTFSETFKEGVQEVFFPSELSLRMPGMNSEDYVFDNVSGNNFEYTLEASKSLRQKQGDSTMTYLNKGQFYPVTLKEGSSNEGIHHPISKVRSVIMVVFAEDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEIAYNAISFTWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQIDTYSYNNRSNKPVHRAYCQIKVFCDKGAERKIRDEERKQSKRKVSDVKVQLLPSHKRTDITVFKPFLDLDTQPVLFIPDVHFTNLQRGSHVLSLPSEELEGEGSVLKRGPFGTEDDFGVPPPAKLTRTEEPKRVLLYVRKESEEVFDALMLKTPSLKGLMEAISDKYDVPHDKIGKIFKKCKKGILVNMDDNIVKHYSNEDTFQLQIEEAGGSYKLTLTEI

Gene
GRHL1
Protein
Grainyhead-like protein 1 homolog
Organism
Pongo abelii
Length
618 amino acids
Function
Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development.
Similarity
Belongs to the grh/CP2 family. Grainyhead subfamily.
Mass
70.158 kDa
Sequence
MTQEYDNKRPVLVLQNEALYPQRRSYTSEDEAWKSFLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRERRSSTAKPEVEHPEPDHSKRNSIPIVTEQPLISAGENRVQVLKNVPFNIVLPHGNQLGIDKRGHLTVPDTTVTVSIATMPTHSIKTETQPHGFTVGIPPAVYHPEPTERVVVFDRNLSTDQFSSGAQAPNAQRRTPDSTFSETFKEGVQEVFFPSDLSLRMPGMNSEDYVFDSVSGNNFEYTLEASKSLRQKPGDSTMTYLNKGQFYPITLKEVSSNEGIHHPISKVRSVTMVVFAEDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEIAYNAISFTWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQIDTYSYNNRSNKPVHRAYCQIKVFCDKGAERKIRDEERKQSKRKVSDVKVPLLPSHKRMDITVFKPFIDLDTQPVLFIPDVHFASLQRGTHVLPIASEELEGEGSVLKRGPYSTEDDFAVPPSAKLARIEEPKRVLLYVRKESEEVFDALMLKTPSLKGLMEAISDKYDVPHDKIGKIFKKCKKGILVNMDDNIVKHYSNEDTFQLQIEEAGGSYKLTLIEI

Gene
grhl1
Protein
Grainyhead-like protein 1 homolog
Organism
Xenopus laevis
Length
609 amino acids
Function
Transcription factor involved in epithelial development (PubMed:15705857). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' and modulates expression of epidermal-specific genes, including XK81A1 (PubMed:15705857). Important regulator of DSG1 in the context of epidermal differentiation. Regulates the maintenance of skin barrier. No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Functions downstream of BMP-signaling cascade modulating endogenous bmp4-responsive targets (PubMed:15705857).
Similarity
Belongs to the grh/CP2 family. Grainyhead subfamily.
Mass
69.732 kDa
Sequence
MTQDYDNKRPVLVLQNDGLYQQRRSYTNEDEAWKSFLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRERRLSAAKQEHDHADHEHSKRNGLPQINEQALLPDNRVQVLKTVPFNIVVPLANQVDKRGHLTTPDTTAAVSIAHPIKTESQSHCFSVGLQSVFHTEPTERIVAFDRAVPSDHFTSNNQPPNSQRRTPDSTFSETYKEDVPEVFFPPDLSLRMGSMNSEDYVFDSVAGNNFEYTLEASKSLRPKPGDSTMTYLNKGQFYPITLKEIGSNKGIHHPISKVRSVIMVVFADDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEIAYNAISFTWDLNDEGKVFISVNCLSTDFSSQKGVKGLPLNLQIDTYSYNNRSNKPVHRAYCQIKVFCDKGAERKIRDEERKQSKRKVQDVKVGLLPTHKRTDITVFKPMMDLDTQPVLFIPDVHFANLQRTTHVLPISPEDMEGELNPGMKRLPFSPEEDFNTPPAKLPRVDEPKRVLLYVRRETEEVFDALMLKTPTLKGLMEAVSEKYEVPIEKIGKIFKKCKKGILVNMDDNIIKHYSNEDTFHLQIEESGGSYKLTLTEI