Protein
ABC transporter GPY2
Organism
Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)
Function
ABC transporter; part of the gene cluster that mediates the biosynthesis of gibepyrone A, a 2H-pyran-2-one metabolite exhibiting a moderate antimicrobial activity against Gram-positive bacteria and yeasts (PubMed:27856636). GPY2 seems to have a minor impact on the efflux of gibepyrone A out of the cell, but it was shown to repress expression of the key gene GPY1 (PubMed:27856636).
Similarity
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Sequence
MPPPNCLLHVEDTFGPVVKGCGSNFDFTLLFEETILCILPLCVAICLAIFRVTRLWKKPVIFKGCFILPLKLIAWNLVLGSQASVVALFSIRDETRTRASIAAGSIGIVGSAILACLSFLEHQRAVRTSSILVLYLLSTIPMDAARARTLWRMLDGRDPAIAVMVLGATKVCALVTEMLWKCSLANRHELCDAPEESNGIIERALMLRMMPIFWAGYRTPLQTEHLSKLDTKLQNAELRPSEKGPKRKQAPIKLAKEIFFSHTYEFLAPIFPRLCYLSLTFAQPFLVRRAIDYISKPKTEGSGERGDGLIAAYALVYYGIAFVSSLYEQSAVRATTVVRADLSMRIYQQSLLLDRVVDTGDSSTTMMTADVERVQLGVRKLHDAWASFVSVAIGLWLIEAQLGLAALVTLGLIGGSLLLGGYWSGRASRFQKNWMAAIEKRLHKTVQVLKGIKSIKQMGAAPAIKTMLEDERQSEIKLSKKFRLQLIALVTLSFTSLTMLPALGLSVHNAVSDKSSGRILTAQTAFQVMTLFNIVSSSIQDCTSHVMAIMVGLGSLQRIESFLNQHTWTDPRKSIRDASISTDESSVGGTSEKKVLTDVAVKIQNVSAKWTEDGEAIIRDATFDVPAHGLTVVAGPTGSGKSTLLRVVLGDLAPSSGTVSVDDSQVAFCDQTPWIANISIKENIVGALPFYEERYRMALHACALDQDIEDLTDGDKHLCGLNGQSVSGGQKVRIALARAIYSKATLVLLDDCLVGLDTNTERHILGEIFAPRGLLSSAPTTTILATSSPRYLPFANYIILIDADGRIVRQGTYAEIAPHIEQLEHDVLQVSDHAATAREPRAQDSDELPNTAITNDIAFKKGANGDWAVYKWYFGVIGWMDFVVFLFLCLGFVIGVIFPQIYLGLWSEKSLQNQIDTLPSFYGIFFGVGSMAWVALFSACVWLFLRIAVRTAALFHHLILTTTLNARMDFFSQTDSGVTLNRFSQDLQITDMELPLAFVGATMNLLMLIAQCIVVTIQSHYAGFAILAIAVVIGFFHEFYLRTSRRLRVMDIEARSPVLSLLLESLDGLATVRAYGWAAWYLRRGIEVLERSQVPFHFLQSAQVTLNLSVDLFVATLALVVISIAVVQMNTSGGSLGLALFNIVGLGQSVKGVVFFWTSLEITLGAVARIRDFTEDTKSEHESDTKPPVEWPSRGEIHFSDVTLTHSTSLPPTISNLTLDIKPGSKMAICGRTGSGKSTLVNSLLGLVQVSSGIITIDDVDISTLAKDEVRSRFVVLPQESLILSVSIREYAKLFGISDEQEIIQGLKKTGLWQTIEQGGGLDMIASSDTFSHGERQLFAMTLACLKKGKLVLMDEPTSHVDNDIQTQLRQAVFDTFPDSTVLCVTHQVATIVDFDIVLVLDDGKIVEQGDPKELLHQPTSRFAQLYSAGEL