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GLYR1

Gene
GLYR1
Protein
Putative oxidoreductase GLYR1
Organism
Homo sapiens
Length
553 amino acids
Function
Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity (PubMed:23260659). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664).
Similarity
Belongs to the HIBADH-related family. NP60 subfamily.
Mass
60.547 kDa
Sequence
MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHNSSDDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVSSGSSERGSKSPLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFHHFLLSQTEKPAVCYQAITKKLKICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH
Protein
Putative oxidoreductase GLYR1: GLYR1

Gene
GLYR1
Protein
Putative oxidoreductase GLYR1
Organism
Pongo abelii
Length
553 amino acids
Function
Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity. Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6.
Similarity
Belongs to the HIBADH-related family. NP60 subfamily.
Mass
60.662 kDa
Sequence
MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHNSSDDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVSSGSSERGSKSPLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTATEPVKDADPHFHHFLLSQTEKPAVCYQAITKKLKICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWDRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPRKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH
Protein
Putative oxidoreductase GLYR1: GLYR1

Gene
GLYR1
Protein
Putative oxidoreductase GLYR1
Organism
Bos taurus
Length
553 amino acids
Function
Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity. Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6.
Similarity
Belongs to the HIBADH-related family. NP60 subfamily.
Mass
60.556 kDa
Sequence
MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHSSADDKNRRNSSEERSRPISGDEKRKLSLSEGKVKKNMGEGKKRVPSGSSERGSKSPLKRAQEQSPRKRGRPPKDEKDLSIPESSTVKGMMAGPMATFKWQPNVSEPVKDADPHFHHFLLSQTEKPAVCYQAITKKLKICEEETGSTSIQAADSTAVNGSVTPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH
Protein
Putative oxidoreductase GLYR1: GLYR1

Gene
GLYR1
Protein
Putative oxidoreductase GLYR1
Organism
Gallus gallus
Length
553 amino acids
Function
May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of MAPK14 and specifically regulating MAPK14 signaling.
Similarity
Belongs to the HIBADH-related family. NP60 subfamily.
Mass
60.601 kDa
Sequence
MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHLHKEEMIKINKGKRFQQAVDAVEEFLRKTKGKDQASSHNSSEEKNRRNSSEERGKQSAREEKRKASLSEGKLKKGTGEGKKRVSSVSSERGSKSPLKRAQDQSPRKRGRPPKDEKDLTIPESSTVKRVMTGTVAGFKWPPSVSEPVKDSDPHFHHFLLSQTEKPAVCYQAITKKLKVCEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDSVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH
Protein
Putative oxidoreductase GLYR1: GLYR1

Gene
Glyr1
Protein
Putative oxidoreductase GLYR1
Organism
Rattus norvegicus
Length
552 amino acids
Function
Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity. Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6.
Similarity
Belongs to the HIBADH-related family. NP60 subfamily.
Mass
60.421 kDa
Sequence
MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHTSADDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVTSGSADRGSKCLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFHHFLLSQTEKPAVCYQAITKKLKICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH
Protein
Putative oxidoreductase GLYR1: Glyr1

Gene
Glyr1
Protein
Putative oxidoreductase GLYR1
Organism
Mus musculus
Length
546 amino acids
Function
Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity. Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6.
Similarity
Belongs to the HIBADH-related family. NP60 subfamily.
Mass
59.716 kDa
Sequence
MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHTSADDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVTSGSADRGSKCLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTATEPVKDADPHFHHFLLSQTEKPAVCYQAITKKLKICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH
Protein
Putative oxidoreductase GLYR1: Glyr1

Gene
glyr1
Protein
Putative oxidoreductase GLYR1
Organism
Xenopus tropicalis
Length
534 amino acids
Function
May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of mapk14 and specifically regulating mapk14 signaling.
Similarity
Belongs to the HIBADH-related family. NP60 subfamily.
Mass
58.475 kDa
Sequence
MAAVSLRQGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCLFVKFFGTEDHAWIKVEQLKPYHAHKEEMIKANKGKRFQQAVDAVEEFLKKAKAKEHAKEHNSSDEKGKKGEGKGKKQTGEKRRKSSESSSHSPQKRSRDQSPRKRGRPPKDDKDSPSPQPSSLKKLAMKTVSRFSWPPPSTEDDLGSDSWLIHGHRTLGTEMILKKPSVTYQAITKRLKISEEDSGSTSIQAADSTAINGNIIPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGAHMGRTPAEVVSTCDITFACVADPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDPETVAELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDQGVYEDCSSCFLAMGKTSFFLGEVGNAARMMLILNMVQGSFMATIAEGMTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDSVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH
Protein
Putative oxidoreductase GLYR1: glyr1

Gene
glyr1
Protein
Putative oxidoreductase GLYR1
Organism
Danio rerio
Length
462 amino acids
Function
May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of mapk14 and specifically regulating mapk14 signaling.
Similarity
Belongs to the HIBADH-related family. NP60 subfamily.
Mass
50.601 kDa
Sequence
MATVHLRIGDLVWGKLGRYPPWPGKVVSPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHPHKEEMIKVNKGKRFQQAVDAVEEYLKKAKGKDQSHSDDKSKSDKGRKAAKPMKIIEEDDEDAFKGGSSDKPASSMEPITKRLKIIEEDTRSTSIQAADSTAINGSITPTDKRIGFLGLGLMGSGVVSNLLKMGHVVTVWNRTAEKCDLFIQEGARLGRTPAEVVSMCDITFSCVSDPKAARDLVLGPSGVLQGIRPGKCYVEMSTVDPETITELSQVITSRGGRFLEAPVSGSQQLSNDGMLVIVAAGDRSVYEDCSSCFQAMGKTSFFIAGEAGNAARMMLILNMVQGSFMATIAEGLTLAQATGQSQQTFLDILCQGQMASTFVDQKCQNILQGNFKPDYYLKHIQKDLRLAISMGDSVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH
Protein
Putative oxidoreductase GLYR1: glyr1

Gene
GLYR1
Protein
Glyoxylate/succinic semialdehyde reductase 1
Organism
Arabidopsis thaliana
Length
289 amino acids
Function
Catalyzes the NADPH-dependent reduction of glyoxylate to glycolate as well as succinic semialdehyde (SSA) to gamma-hydroxybutyrate in vitro. May function in redox homeostasis and play a role in oxidative stress tolerance by detoxifying glyoxylate and SSA generated in glycolate metabolism and GABA metabolism, respectively.
Similarity
Belongs to the HIBADH-related family. NP60 subfamily.
Mass
30.692 kDa
Sequence
MEVGFLGLGIMGKAMSMNLLKNGFKVTVWNRTLSKCDELVEHGASVCESPAEVIKKCKYTIAMLSDPCAALSVVFDKGGVLEQICEGKGYIDMSTVDAETSLKINEAITGKGGRFVEGPVSGSKKPAEDGQLIILAAGDKALFEESIPAFDVLGKRSFYLGQVGNGAKMKLIVNMIMGSMMNAFSEGLVLADKSGLSSDTLLDILDLGAMTNPMFKGKGPSMNKSSYPPAFPLKHQQKDMRLALALGDENAVSMPVAAAANEAFKKARSLGLGDLDFSAVIEAVKFSRE
Protein
Glyoxylate/succinic semialdehyde reductase 1: GLYR1