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GLI1

Gene
gli1
Protein
Zinc finger protein GLI1
Organism
Xenopus laevis
Length
1360 amino acids
Function
Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3' (By similarity). May regulate the transcription of specific genes during normal development (PubMed:9216996). Mediates SHH signaling (PubMed:9216996). Plays a role in cell proliferation and differentiation via its role in SHH signaling (By similarity).
Similarity
Belongs to the GLI C2H2-type zinc-finger protein family.
Mass
149.422 kDa
Fragment
single
Sequence
MASRQCPPAAVFNSMNPPVNSYVEHCYLRSPNVMAEGMNEMPYCHQTNLMTSHHGFGLAQGSDHLAGTDGSRFSTPRSTMKLSKKRAMSISPLSDASIDLQTMIRTSPNSLVAFINSRCSSASGSYGHLSIGTISPSLGYQNCLNHQRPQAGPYGSNPLMPYNSHEHLSSRGMSMLQPRSSVKHCQLKSEPLSITGLDTIGSKRLEDGSEGDISSPASVGTQDPLLGLLDGRDDLEKDDGKHEPETVYETNCHWESCTKEFDTQEHLVHHINNEHIHGEKKEFVCHWQDCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRGDGMLRAQPGHEGPGNQNVKGENQLDMEASSACKEDGRLAVPDITLKSQPSPGGQSSCSSERSPLGSTNNNDSGVEMNANTGGSFEDLTNLDDIPSVDSMGTAGASALRKLENLRIDKLNQLRKTPSSGKMVKLPSIHNSGPQGDMSVVCGPLGMSHNQHGIELPASSHVNHLNDRRNSTTSTMSSAYTVSRRSSVVSPYLPNQRAGDSGNMVDSYDISTDPSGHSNEAVCASGLPGLTPAQQYRLKAKYAAATGGPPPTPLPNMERMNTNNRMAFASSDYRGSAISSLQRRHSSNEYHNYGTGIIHPAQAPGAGIRRASDPARTGGDIQAVPKVQRFKSMTNMNVSMMGRQGTSIQQAYGGSDANLQRHMFSPRPPSITENVFMETAGPDEVCHTKEQGFIQSNEMQHYMNYQGQGSQLTAPNDHMNFNPQIHGLDGQSQNVYSHSQRAISNMHLNAENYSGQSNVSNFNQCQMTAHNQHFQNTRQAYNCANLPVQWNEVSSGTMDNPVQRPNHQIMHQNMSPGNHCQSQLSNCTVPESTKQGCPVNRNSCQQGMYMNNQKYNHGGQVQVKPEQQFHHSAPAMMSCQNMKHPSRQEHHFTKTNTMPLSSEATNCDYQGQQDSTQNSCFNVGLNLNLLSPPGRRSQTPIMQVKEIMVRNYVQSQQALMWEQHPKSMAMMTNSGDDVDTRQNQHKNTLNAAVYMGPKYMNYQGKPSPNNLMSPSSQDSQSSHTKAMGSPSSQCYNFDMMPHPPCGPKPLSRQHSVSSQSTYMGSPNQLSPSYQSSESSPRRMACLPPIQPQSEVTNNTSMMYYTGQMEMHQSKPGVHKLTTPLNLNQTSCDGHQHGQYNASHSFLKTVPYTSSCPAANTLDSLDLENTQIDFTAIIDDADNALMPGNISPNVLAGSSQASSHLTTLRNTGAVVPNMVVGDLNSMLSSLAGENKYLNTM

Gene
gli1
Protein
Zinc finger protein GLI1
Organism
Xenopus laevis
Length
1360 amino acids
Function
Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3' (By similarity). May regulate the transcription of specific genes during normal development (PubMed:9216996). Mediates SHH signaling (PubMed:9216996). Plays a role in cell proliferation and differentiation via its role in SHH signaling (By similarity).
Similarity
Belongs to the GLI C2H2-type zinc-finger protein family.
Mass
149.422 kDa
Fragment
single
Sequence
MASRQCPPAAVFNSMNPPVNSYVEHCYLRSPNVMAEGMNEMPYCHQTNLMTSHHGFGLAQGSDHLAGTDGSRFSTPRSTMKLSKKRAMSISPLSDASIDLQTMIRTSPNSLVAFINSRCSSASGSYGHLSIGTISPSLGYQNCLNHQRPQAGPYGSNPLMPYNSHEHLSSRGMSMLQPRSSVKHCQLKSEPLSITGLDTIGSKRLEDGSEGDISSPASVGTQDPLLGLLDGRDDLEKDDGKHEPETVYETNCHWESCTKEFDTQEHLVHHINNEHIHGEKKEFVCHWQDCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRGDGMLRAQPGHEGPGNQNVKGENQLDMEASSACKEDGRLAVPDITLKSQPSPGGQSSCSSERSPLGSTNNNDSGVEMNANTGGSFEDLTNLDDIPSVDSMGTAGASALRKLENLRIDKLNQLRKTPSSGKMVKLPSIHNSGPQGDMSVVCGPLGMSHNQHGIELPASSHVNHLNDRRNSTTSTMSSAYTVSRRSSVVSPYLPNQRAGDSGNMVDSYDISTDPSGHSNEAVCASGLPGLTPAQQYRLKAKYAAATGGPPPTPLPNMERMNTNNRMAFASSDYRGSAISSLQRRHSSNEYHNYGTGIIHPAQAPGAGIRRASDPARTGGDIQAVPKVQRFKSMTNMNVSMMGRQGTSIQQAYGGSDANLQRHMFSPRPPSITENVFMETAGPDEVCHTKEQGFIQSNEMQHYMNYQGQGSQLTAPNDHMNFNPQIHGLDGQSQNVYSHSQRAISNMHLNAENYSGQSNVSNFNQCQMTAHNQHFQNTRQAYNCANLPVQWNEVSSGTMDNPVQRPNHQIMHQNMSPGNHCQSQLSNCTVPESTKQGCPVNRNSCQQGMYMNNQKYNHGGQVQVKPEQQFHHSAPAMMSCQNMKHPSRQEHHFTKTNTMPLSSEATNCDYQGQQDSTQNSCFNVGLNLNLLSPPGRRSQTPIMQVKEIMVRNYVQSQQALMWEQHPKSMAMMTNSGDDVDTRQNQHKNTLNAAVYMGPKYMNYQGKPSPNNLMSPSSQDSQSSHTKAMGSPSSQCYNFDMMPHPPCGPKPLSRQHSVSSQSTYMGSPNQLSPSYQSSESSPRRMACLPPIQPQSEVTNNTSMMYYTGQMEMHQSKPGVHKLTTPLNLNQTSCDGHQHGQYNASHSFLKTVPYTSSCPAANTLDSLDLENTQIDFTAIIDDADNALMPGNISPNVLAGSSQASSHLTTLRNTGAVVPNMVVGDLNSMLSSLAGENKYLNTM

Gene
Gli1
Protein
Zinc finger protein GLI1
Organism
Mus musculus
Length
1111 amino acids
Function
Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling.
Similarity
Belongs to the GLI C2H2-type zinc-finger protein family.
Mass
118.56 kDa
Sequence
MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETSSCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQSRGPRATCQLKSELDMMVGKCPEDPLEGDMSSPNSTGTQDHLLGMLDGREDLEREEKPEPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKREREGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARGSGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFKSLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLNPYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPENWGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLVCNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPASANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPEVGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTPSPSGPPNMAVGNMSVLLGSLPGETQFLNSSA

Gene
Gli1
Protein
Zinc finger protein GLI1
Organism
Mus musculus
Length
1111 amino acids
Function
Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling.
Similarity
Belongs to the GLI C2H2-type zinc-finger protein family.
Mass
118.56 kDa
Sequence
MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETSSCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQSRGPRATCQLKSELDMMVGKCPEDPLEGDMSSPNSTGTQDHLLGMLDGREDLEREEKPEPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKREREGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARGSGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFKSLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLNPYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPENWGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLVCNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPASANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPEVGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTPSPSGPPNMAVGNMSVLLGSLPGETQFLNSSA

Gene
GLI1
Protein
Zinc finger protein GLI1
Organism
Homo sapiens
Length
1106 amino acids
Function
Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.
Similarity
Belongs to the GLI C2H2-type zinc-finger protein family.
Mass
117.904 kDa
Sequence
MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETNSCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLKSELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREGGPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSSLDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLERRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGGTSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSLGCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNPYMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETWGEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGPPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCNYVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHKSGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGPPNMAVGNMSVLLRSLPGETEFLNSSA

Gene
GLI1
Protein
Zinc finger protein GLI1
Organism
Homo sapiens
Length
1106 amino acids
Function
Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.
Similarity
Belongs to the GLI C2H2-type zinc-finger protein family.
Mass
117.904 kDa
Sequence
MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETNSCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLKSELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREGGPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSSLDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLERRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGGTSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSLGCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNPYMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETWGEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGPPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCNYVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHKSGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGPPNMAVGNMSVLLRSLPGETEFLNSSA

Gene
GLI1
Protein
Zinc finger protein GLI1
Organism
Gallus gallus
Length
556 amino acids
Function
Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3' (By similarity). May regulate the transcription of specific genes during normal development (PubMed:8948590). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract (PubMed:8948590). Mediates SHH signaling (PubMed:8948590). Plays a role in cell proliferation and differentiation via its role in SHH signaling.
Similarity
Belongs to the GLI C2H2-type zinc-finger protein family.
Mass
60.216 kDa
Fragment
single
Sequence
MFNPVTPQARPYAEHCCPRPLHGASAGTPGLQGLDFPVCHQPNLASSHHGYGLVPGTEHPGGAADGSRFSTPRGAGKLGKKRALSISPLSDSSVDLQTVIRTSPNSLVAFINSRCASAGGSYGHLSISTISPSLGYQNPPGQQKGQGQLFSHTPPLPPCSSHETLSSRPGLLHPTPARGTIKHCQQLKLERSLSSPLTAKYPEEKSEGDISSPASTGTQDPLLGMLSVRDDLEKEDGKPESETIYETNCYWDGCAKEFDTQEQLVHHINNEHIHGEKKEFVCHWAACSREQRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKHRGSVVPGHALPASAAPQDMKQEKNTNGPAEIRKDDGKLLVPDLVSKPQPSPGGQSSCSSDRSPLGSTTNNDSGVEMTGNTGGSYEDLVHAGGCGARGSHGHLGADGLQKLENLRIDKLKQMRKPSTKGLNLPAIPEPVCRRCVRVCV