Protein
Regulator of telomere elongation helicase 1 homolog
Organism
Drosophila virilis
Function
ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.
Similarity
Belongs to the helicase family. RAD3/XPD subfamily.
Sequence
MPENIIAGIPVHFPFEPYEVQRAYMEKVIMCLRDGTNGVLESPTGTGKTLSLLCASLAWIRTRQSEQQQYMQKLQLDQQKQATGGAGAGVADLNAVMGKANNWGVPKVIYASRTHSQLSQAMRELKRTAYANMKSVVLGSRDQLCIHPDVMREQGNSNKVNMCKLKVHAKTCSFQLRVESKKDHPDFRGPSIMDIEDLVKVGQRLKMCPYFASKELVNGADITFMPYNYLLDPKARKANKIELSNTIVILDEAHNIEKICEESASVQIRSSDVAMAIEDITHIMKIFTSGDAQDTGGPEEPKDFTLDDLTLLKEMLLELEKAIDGVVVDNKAEGTTYPAAHIYELLGKANFTYGNCATIVALLDKLVQYLMVASQHSTMLRKGGSFMVLADLLNIVFANKEDVMSKVHRSFKVHVEIEDNKQSKNAANSAKPQTGWLGKGNNAASSVTKAAKIINFWCFNPGFGMEQLLNAHVRSVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDRSQVYVKIIGTGPDREQLISNYKNRDNPKYISSLGQTILNVSRIVPDGLLVFFPSYPMLNQCVDAWQASGLWADISCRKPIFLEPRGKDQFTSTMEEFYQAIRDSKGACFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVVLKRRYLETNRTKENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDARFQDMSQVQQLSKWIRGHLGARPQSSPFGPIVRELRQFFKHAEQTMAQPEERVVEPLLQTVCKEEQPTLACASSSQITIKREPGTGGTKFQLASELAAQAEMANTIKTWTPADYANAAGSSTLGRRAPDAMDFMSRLNANVTSIDFNSADAGQDLVKIHKRERSSPTASESSMIAKKRYKLIGNGPLKTEPSEPATTSSSFCPTPAQSQLKEAPESRADFLREVRSVIDCDQFRSFGKALLAYKTGGDGCFETLMVLLLDVLGAPQLRYLLLGMRRYLKNEHKLEFDVRLASFQAT