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GET3

Gene
GET3
Protein
ATPase GET3
Organism
Saccharomyces cerevisiae (strain RM11-1a)
Length
354 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.
Similarity
Belongs to the arsA ATPase family.
Mass
39.354 kDa
Sequence
MDLTVEPNLHSLITSTTHKWIFVGGKGGVGKTTSSCSIAIQMALSQPNKQFLLISTDPAHNLSDAFGEKFGKDARKVTGMNNLSCMEIDPSAALKDMNDMAVSRANNNGSDGQGDDLGSLLQGGALADLTGSIPGIDEALSFMEVMKHIKRQEQGEGETFDTVIFDTAPTGHTLRFLQLPNTLSKLLEKFGEITNKLGPMLNSFMGAGNVDISGKLNELKANVETIRQQFTDPDLTTFVCVCISEFLSLYETERLIQELISYDMDVNSIIVNQLLFAENDQEHNCKRCQARWKMQKKYLDQIDELYEDFHVVKMPLCAGEIRGLNNLTKFSQFLNKEYNPITDGKVIYELEDKE

Gene
GET3
Protein
ATPase GET3
Organism
Saccharomyces cerevisiae (strain YJM789)
Length
354 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.
Similarity
Belongs to the arsA ATPase family.
Mass
39.354 kDa
Sequence
MDLTVEPNLHSLITSTTHKWIFVGGKGGVGKTTSSCSIAIQMALSQPNKQFLLISTDPAHNLSDAFGEKFGKDARKVTGMNNLSCMEIDPSAALKDMNDMAVSRANNNGSDGQGDDLGSLLQGGALADLTGSIPGIDEALSFMEVMKHIKRQEQGEGETFDTVIFDTAPTGHTLRFLQLPNTLSKLLEKFGEITNKLGPMLNSFMGAGNVDISGKLNELKANVETIRQQFTDPDLTTFVCVCISEFLSLYETERLIQELISYDMDVNSIIVNQLLFAENDQEHNCKRCQARWKMQKKYLDQIDELYEDFHVVKMPLCAGEIRGLNNLTKFSQFLNKEYNPITDGKVIYELEDKE

Gene
GET3
Protein
ATPase GET3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
354 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.
Similarity
Belongs to the arsA ATPase family.
Mass
39.354 kDa
Sequence
MDLTVEPNLHSLITSTTHKWIFVGGKGGVGKTTSSCSIAIQMALSQPNKQFLLISTDPAHNLSDAFGEKFGKDARKVTGMNNLSCMEIDPSAALKDMNDMAVSRANNNGSDGQGDDLGSLLQGGALADLTGSIPGIDEALSFMEVMKHIKRQEQGEGETFDTVIFDTAPTGHTLRFLQLPNTLSKLLEKFGEITNKLGPMLNSFMGAGNVDISGKLNELKANVETIRQQFTDPDLTTFVCVCISEFLSLYETERLIQELISYDMDVNSIIVNQLLFAENDQEHNCKRCQARWKMQKKYLDQIDELYEDFHVVKMPLCAGEIRGLNNLTKFSQFLNKEYNPITDGKVIYELEDKE

Gene
GET3
Protein
ATPase GET3
Organism
Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229)
Length
353 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
39.337 kDa
Sequence
MDLVVEPNLHSLINSSTHKWIFVGGKGGVGKTTSSCSIAIQMAQSQPHKQFLLISTDPAHNLSDAFGEKFGKDARRVTGMNNLSCMEIDPSAALKDMNDMAVSQANENGAQGDDGLGGLLQGGALAELTGSIPGIDEALSFMEVMKHIKNQEKGEGERYDTVIFDTAPTGHTLRFLQLPNTLSKLLEKFGEITGRLGPMLNSLAGAGNVDISTKLNQLKESVETIKDQFTNPDLTTFVCVCISEFLSLYETERLIQELISYDMDVNSIIVNQLLFADDDQEHNCKRCQARWKMQKKYLDQIDELYEDFHVVKMPLCAGEIRGLENLRKFSRFLNKEYNPAMDNKIIYELENKK

Gene
GET3
Protein
ATPase GET3
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294)
Length
352 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
38.992 kDa
Sequence
MDLTVDPNLHSLINSTTHRWIFVGGKGGVGKTTSSCSIAIQMALSQPSKQFLLISTDPAHNLSDAFGEKFGKDARKVTGMDNLSCMEIDPSAALNDMNDMAVSRANENGNGGDGLSDILQGGALADLTGSIPGIDEALSFMEVMKHIKNQENGEGDRYDTVIFDTAPTGHTLRFLQLPNTLSKLLEKFGEITGKLGPMLNSLAGAGNVDISGKLNELKENVEKIRQQFTDPDLTTFVCVCISEFLSLYETERLIQELISYDMDVNSIIVNQLLFAEYDAEHNCKRCQARWKMQKKYLDQIDELYEDFHVVKMPLCAGEIRGLNNLKKFSAFLNKEYDPVADGKVIYELEEKN

Gene
GET3
Protein
ATPase GET3
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
349 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
38.592 kDa
Sequence
MTDITPEASLRSLINSTTHKWIFVGGKGGVGKTTSSCSIAIQMALAQPTKQFLLISTDPAHNLSDAFNEKFGKDARKVTGMDNLSCMEIDPSAALKDVNDMAIANGGDDDGLSGLLQGGALADLTGSIPGIDEALSFMEVMKHIKKQEQGDGEHFDTVIFDTAPTGHTLRFLQLPTTLTKVLDKFGAIAGRLGPMLNSFAGNPNVDVLGKMNELKESVQKIKKQFTDPDLTTFVCVCISEFLSLYETERLIQELISYDMDVNSIIVNQLLFAESDKEHNCKRCQARWKMQKKYLSQIDELYEDFHIVKMPLCAGEIRGLENLKKFSCFLNNKYDPETDGELVYQLEQGL

Gene
GET3
Protein
ATPase GET3
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)
Length
347 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
38.904 kDa
Sequence
MDFELEPTLESIVEHDSLKWIFVGGKGGVGKTTTSSSIAVQLALSKPNDQFLLISTDPAHNLSDAFCQKFGKDARPVEGLPNLSCMEIDPEAAMSDLQQQASQYNNDPSDPMKNIMNDMTGSIPGIDEALSFMEVLKHIKNQKASDGDSDEKTVAYKTIIFDTAPTGHTLRFLQLPATLEKLLGKFKQLSGKLGPMLNMLGGGQQQDIFEKMNEIQKNVSEVNEQFTNPDLTTFVCVCISEFLSLYETERMIQELVSYNMDVNSIVVNQLLFADNDGSCKRCASRWKMQQKYLDQMAELYEDYHVVKMPLLGTEVRGIDNLKKFSKFLLSPYDPEKDGSLVFDMEEK

Gene
GET3
Protein
ATPase GET3
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
347 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
39.294 kDa
Sequence
MDFELEPTLESIVQQDTLKWIFVGGKGGVGKTTTSSSIAVQLALNHPNDQFLLISTDPAHNLSDAFCQKFGKDARKVDGLSNLSCMEIDPEAAMSDLQQQAQQYNNDPNDPLKSMMNDMTGSIPGIDEALSFMEVLKHIKSQKVDENDDKDKISYRTIIFDTAPTGHTLRFLQLPSTLQKLLSKFQALSGKFGPMMSMLGGGNQQEMFDKLNEVQKNVTEVNEQFTNPDLTTFVCVCISEFLSLYETERMIQELMSYNMDVNSIVVNQLLFADDDEKPCKRCVSRWKMQKKYLDQMAELYEDYHLVKMPLLGTEIRGVENLKKFSKFLLTPYDPKVNGDLVTSLEEK

Gene
GET3
Protein
ATPase GET3
Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)
Length
343 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.625 kDa
Sequence
MSSTAIIGDDDVLEPTLQCLLDQKTLRWIFVGGKGGVGKTTTSCSLAIQLSKVRKSVLLISTDPAHNLSDAFGQKFGKEARLIDGYDNLSAMEIDPNGSIQDLMASGGADGNDDAMGGFGLGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALSKLSQLSGQFGPMLNSVLGARGGLPGGQNLDDILSKMESLRETIAEVNSQFKDADMTTFVCVCIAEFLSLYETERMIQELTSYHIDTHCIVVNQLLFPGKDNACQQCGARRKMQKKYLNEIKDLYEDFNVVRMPLLVEEVRGREKLESFSDMLVHPFQPAHED

Gene
GET3
Protein
ATPase GET3
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Length
343 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.891 kDa
Sequence
MSTALIDVDSMEPSLQSILDQKSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFSQKFGKEARLIDGFTNLSAMEIDPNGSMQDLLAGQGADEGGAAADGMAGMGGMMQDLAFAIPGIDEAMSFAEVLKQVKSLSYETIIFDTAPTGHTLRFLQFPSVLEKALAKVSQLSSQYGPLLNGFLGGQGQLPNGQSLPEMMEKLEQLRETISEVNTQFKDENLTTFVCVCIAEFLSLYETERMIQELASYNIDTHCIVVNQLLFPKKGSKCDHCDARRRMQKKYLDQIEELYDEFNVVKMPMLIEEVRGKEKLEKFSEMLVKPYVPPEADE

Gene
GET3
Protein
ATPase GET3
Organism
Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
Length
341 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.433 kDa
Sequence
MSSTAMVSGDDSLEPTLQSLLDQKTLRWVFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGFDNLSAMEIDPNGSIQDLLSTGGDQADDPMAGLGLGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGARGGLPGGQNLDEILSKMESLRETIGEVNAQFKDADLTTFVCVCIAEFLSLYETERMIQELTSYQIDTHCIVVNQLLFPGKDSSCEQCKARRKMQKKYLNEIEDLYEDFNVVRMPMLVEEVRGKEKLEKFSDMLVNPYVPPEE

Gene
GET3
Protein
ATPase GET3
Organism
Ajellomyces capsulatus (strain H143)
Length
341 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.416 kDa
Sequence
MSSTAMVSGDDSLEPTLQSLLDQKTLRWVFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGFDNLSAMEIDPNGSIQDLLATGGDQADDPMAGLGLGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGARGGLPGGQNLDEILSKMESLRETIGEVNAQFKDADLTTFVCVCIAEFLSLYETERMIQELTSYQIDTHCIVVNQLLFPGKDSSCEQCKARRKMQKKYLNEIEDLYEDFNVVRMPMLVEEVRGKEKLEKFSNMLVNPYVPPEE

Gene
GET3
Protein
ATPase GET3
Organism
Ajellomyces capsulatus (strain NAm1 / WU24)
Length
341 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.416 kDa
Sequence
MSSTAMVSGDDSLEPTLQSLLDQKTLRWVFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGFDNLSAMEIDPNGSIQDLLATGGDQADDPMAGLGLGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGARGGLPGGQNLDEILSKMESLRETIGEVNAQFKDADLTTFVCVCIAEFLSLYETERMIQELTSYQIDTHCIVVNQLLFPGKDSSCEQCKARRKMQKKYLNEIEDLYEDFNVVRMPMLVEEVRGKEKLEKFSNMLVNPYVPPEE

Gene
GET3
Protein
ATPase GET3
Organism
Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)
Length
341 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.436 kDa
Sequence
MSSTAIVSGDESLEPTLQNLLDQKTLRWVFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLIDGFDNLSAMEIDPNGSIQDLLAAGGDQADDPMGGLGLGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIIFDTAPTGHTLRFLQFPTVLEKALGKLSQLSSQFGPMLNSVLGARGGLPGGQNLDEILSKMESLRETIGEVNAQFKDADLTTFVCVCIAEFLSLYETERMIQELTSYQIDTHCIVVNQLLFPGKDSSCEQCKARRKMQKKYLNEIEELYEDFNVVRMPMLVEEVRGKEKLEKFSNMLINPYIPPQE

Gene
get3
Protein
ATPase get3
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Length
341 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.563 kDa
Sequence
MSSAVVHSDDLMEPTLQSVVNQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGYTNLSAMEIDPNGSIQDLLASGEGQGDDPLSGMGVGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGSRGGLPGGQNIDELLQKMESLRETISEVNSQFKDADLTTFVCVCIAEFLSLYETERMIQELTSYNIDTHAIVVNQLLFPKQSSECEQCNARRKMQKKYLEQIEELYEDFNVVRMPLLVEEVRGKEKLEKFSDMLVNPYVPPEGN

Gene
GET3
Protein
ATPase GET3
Organism
Blastomyces gilchristii (strain SLH14081)
Length
341 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.436 kDa
Sequence
MSSTAIVSGDESLEPTLQNLLDQKTLRWVFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLIDGFDNLSAMEIDPNGSIQDLLAAGGDQADDPMGGLGLGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIIFDTAPTGHTLRFLQFPTVLEKALGKLSQLSSQFGPMLNSVLGARGGLPGGQNLDEILSKMESLRETIGEVNAQFKDADLTTFVCVCIAEFLSLYETERMIQELTSYQIDTHCIVVNQLLFPGKDSSCEQCKARRKMQKKYLNEIEELYEDFNVVRMPMLVEEVRGKEKLEKFSNMLINPYIPPQE

Gene
GET3
Protein
ATPase GET3
Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01)
Length
341 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.431 kDa
Sequence
MSSAAMLTAEDSLEPTLQNLLDQKTLRWVFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLIDGFTNLSAMEIDPNGSIQDLLAASGGQGDDSMGGLGIGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIIFDTAPTGHTLRFLQFPTVLEKALAKLAQLSTQFGPMLNSILGGRGGLPGGQNLDEILSKMESLRETIAEVNAQFKDADLTTFVCVCIAEFLSLYETERMIQELTSYHIDTHCIVVNQLLFPGKDSSCEQCKARRKMQKKYLNEIEELYEDFNVVRMPMLVEEVRGKEKLEKFSDMLVHPYVPPQE

Gene
GET3
Protein
ATPase GET3
Organism
Paracoccidioides brasiliensis (strain Pb18)
Length
341 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.428 kDa
Sequence
MSSAAMVKAEDSLEPTLQNLLDQKTLRWVFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLIDGFTNLSAMEIDPNGSIQDLLAAGGGQGDDSMGGLGIGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIIFDTAPTGHTLRFLQFPTVLEKALAKLAQLSTQFGPMLNSILGGRGGLPGGQNLDEILSKMESLRETIAEVNAQFKDADLTTFVCVCIAEFLSLYETERMIQELTSYHIDTHCIVVNQLLFPGKDSSCEQCKARRKMQKKYLNEIEELYEDFNVVRMPMLVEEVRGKEKLEKFSDMLIHPYVPPQE

Gene
GET3
Protein
ATPase GET3
Organism
Paracoccidioides brasiliensis (strain Pb03)
Length
341 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.428 kDa
Sequence
MSSAAMVKAEDSLEPTLQNLLDQKTLRWVFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLIDGFTNLSAMEIDPNGSIQDLLAAGGGQGDDSMGGLGIGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIIFDTAPTGHTLRFLQFPTVLEKALAKLAQLSTQFGPMLNSILGGRGGLPGGQNLDEILSKMESLRETIAEVNAQFKDADLTTFVCVCIAEFLSLYETERMIQELTSYHIDTHCIVVNQLLFPGKDSSCEQCKARRKMQKKYLNEIEELYEDFNVVRMPMLVEEVRGKEKLEKFSDMLIHPYVPPQE

Gene
get3
Protein
ATPase get3
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Length
340 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.62 kDa
Sequence
MSSAAVVHHDDLMEPTLQSIINQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKARKSVLLISTDPAHNLSDAFGQKFGKEARLVDGYSNLSAMEIDPNGSIQDLLASGEAQGEDPMAGLGMGNMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGARGGLPGGQNIDELLQKMESLRETISEVNTQFKNPDMTTFVCVCIAEFLSLYETERMIQELTSYSIDTHAIVVNQLLFPKKGSECEQCNARRKMQQKYLEQIEELYEDFNVVRMPLLVEEVRGKEKLEKFSEMLVHPYVPPQ

Gene
get3
Protein
ATPase get3
Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)
Length
340 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.44 kDa
Sequence
MSSTAVVHGDDLMEPTLQSILSQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGYSNLSAMEIDPNGSIQDLLASGDSQGDDPLAGLGMGNMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGARGGLPGGQNIDELLQKMESLRETISEVNTQFKNPDMTTFVCVCIAEFLSLYETERMIQELTSYGIDTHAIVVNQLLFPKEGSGCEQCNARRKMQKKYLEQIEELYEDFNVVRMPLLVEEVRGKEKLEKFSEMLVHPYVPPQ

Gene
get3
Protein
ATPase get3
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
340 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.44 kDa
Sequence
MSSTAVVHGDDLMEPTLQSILSQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGYSNLSAMEIDPNGSIQDLLASGDSQGDDPLAGLGMGNMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGARGGLPGGQNIDELLQKMESLRETISEVNTQFKNPDMTTFVCVCIAEFLSLYETERMIQELTSYGIDTHAIVVNQLLFPKEGSGCEQCNARRKMQKKYLEQIEELYEDFNVVRMPLLVEEVRGKEKLEKFSEMLVHPYVPPQ

Gene
get3
Protein
ATPase get3
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Length
340 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.582 kDa
Sequence
MSSTAVVHDDDLMEPSLQSIVNQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGFTNLSAMEIDPNGSIQDLLASGDAQQDDPMAGLGVNNMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGARGGLPGGQNLDELLQKMESLRETISEVNSQFKDADLTTFVCVCIAEFLSLYETERMIQELTSYSIDTHAIVVNQLLFPKDGSECDQCNARRKMQKKYLEQIEELYEDFNVVRMPLLVEEVRGKEKLEKFSDMLVHPYVPPN

Gene
get3
Protein
ATPase get3
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Length
340 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.472 kDa
Sequence
MSSTAVVHGDDLMEPTLQSILSQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGYSNLSAMEIDPNGSIQDLLASGESQGDDPMAGLGMGNMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGARGGLPGGQNIDELLQKMESLRETISEVNTQFKNPDMTTFVCVCIAEFLSLYETERMIQELTSYGIDTHAIVVNQLLFPKEGSGCEQCNARRKMQKKYLEQIEELYEDFNVVRMPLLVEEVRGKEKLEKFSEMLVHPYVPPQ

Gene
get3
Protein
ATPase get3
Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)
Length
340 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.601 kDa
Sequence
MSSAVVHGDDLDMEPTLQSVLNQNTLRWIFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLIDGYSNLSAMEIDPNGSIQDLLATGDGQGEDPMAGLGMGNMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSTQFGPMLNSILGARGGLPGGQNMDELLQKMESLRETISEVNTQFKNPDMTTFVCVCIAEFLSLYETERMIQELTSYNIDTHSIVVNQLLFPKEGSDCEQCTARRKMQKKYLDQIEELYEDFNVVRMPMLVEEVRGKEKLEKFSEMLVTPYVPPQ

Gene
get3
Protein
ATPase get3
Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)
Length
340 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.544 kDa
Sequence
MSTAVINTDDDQLEPTLQSILDQKSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFSQKFGKEARLINGFENLSAMEIDPNGSIQELMGQAEEGEGPAAGMGGMMQDLAFAIPGIDEAMSFAEVLKQVKSLSYETIIFDTAPTGHTLRFLQFPTVLEKALAKVSQLSTQFGPMLNGLLGANGSLPNGQNLGEMMEKLEGLRETISEVNGQFKDENLTTFVCVCIPEFLSLYETERMIQELSSYHIDTHCIVVNQLLFPKKGSDCDQCNARRKMQKKYLEQIEELYDEFNVVKMPLLVEEVRGKERLEKFSEMLITPYVPPAGGL

Gene
get3
Protein
ATPase get3
Organism
Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Length
340 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.572 kDa
Sequence
MSSTALIHDDEALEPTLQSILDQKTLRWIFVGGKGGVGKTTTSCSLAIQLSKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGFTNLSAMEIDPNGSIQDLLASGGEAQEDPLAGLGMGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGSRGGLPGGQNLDDLMSKMESLRETISEVNTQFKNPDMTTFVCVCIAEFLSLYETERMIQELTSYGIDTHAIVVNQLLFPKKDNPCEQCNARRKMQKKYLEQIEELYEDFNVVRMPLLVEEVRGKEKLEKFSEMLVKPYVPPE

Gene
get3
Protein
ATPase get3
Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)
Length
340 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.502 kDa
Sequence
MSSTALIHDDEALEPTLQSILDQKTLRWIFVGGKGGVGKTTTSCSLAIQLSKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGFTNLSAMEIDPNGSIQDLLASGGEAQDDPLAGLGMGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSGQFGPMLNSILGSRGGLPGGQNLDDLMSKMESLRETISEVNTQFKNADMTTFVCVCIAEFLSLYETERMIQELTGYSIDTHAIVVNQLLFPKKDNPCEQCNARRKMQKKYLEQIEELYEDFNVVRMPLLVEEVRGKEKLEKFSEMLVKPYVPPE

Gene
get3
Protein
ATPase get3
Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Length
339 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.417 kDa
Sequence
MSTAVVQADDLMEPSLQSIVSQDTLRWIFVGGKGGVGKTTTSCSLAIQLAKARKSVLLISTDPAHNLSDAFGQKFGKEARLVDGYTNLSAMEIDPNGSIQDLLASGEGQGDDPMAGLGVGNMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGSRGGLPGGQNIDELLQKMESLRETISEVNTQFKNPDMTTFVCVCIAEFLSLYETERMIQELTSYNIDTHAIVVNQLLFPKQGSECEQCNARRKMQKKYLEQIEELYEDFNVVRMPLLVEEVRGKEKLEKFSDMLIHPYVPPQ

Gene
get3
Protein
ATPase get3
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
339 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.417 kDa
Sequence
MSTAVVQADDLMEPSLQSIVSQDTLRWIFVGGKGGVGKTTTSCSLAIQLAKARKSVLLISTDPAHNLSDAFGQKFGKEARLVDGYTNLSAMEIDPNGSIQDLLASGEGQGDDPMAGLGVGNMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGSRGGLPGGQNIDELLQKMESLRETISEVNTQFKNPDMTTFVCVCIAEFLSLYETERMIQELTSYNIDTHAIVVNQLLFPKQGSECEQCNARRKMQKKYLEQIEELYEDFNVVRMPLLVEEVRGKEKLEKFSDMLIHPYVPPQ

Gene
get3
Protein
ATPase get3
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
339 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.475 kDa
Sequence
MSTAVINADDDHMEPTLQSILDQRSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFSQKFGKEARLIDGFDNLSAMEIDPNGSIQDLLAGQGENEGAGDMGGVGGMMQDLAFAIPGIDEAMSFAEVLKQVKSLSYETIIFDTAPTGHTLRFLQFPSVLEKALAKVSQLSSQYGPLLNGFLGSNGTLPNGQNLNEMMEKLETLRATISEVNTQFKDERLTTFVCVCIPEFLSLYETERMIQELASYGIDTHSIVVNQLLFPKPGSDCEQCTARRKMQKKYLDQIEELYDEFNVVKMPLLVEEVRGKEKLEKFSEMLVKPFVPPQ

Gene
GET3
Protein
ATPase GET3
Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)
Length
339 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.39 kDa
Sequence
MSTAVINADDDAMEPTLQSILDQRSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFSQKFGKDARKVDGFENLFAMEIDPNGSMQDLLAGQAEGEGAEGLGGMGGMMQDLALSIPGIDEAMSFAEVLKQVKSLSYETIIFDTAPTGHTLRFLQFPSVLEKALKKISQLSSQFGGVLNGLLGANGALPNGQNLGEMMEKLEALRATISEVNQQFKDERLTTFVCVCIPEFLSLYETERMIQELASYQIDTHCIVVNQLLFPKPGSDCEQCTARRRMQKKYLDQIEELYDEFNVVKMPLLVEEVRGKEKLEKFSEMLVKPFVPPS

Gene
get3
Protein
ATPase get3
Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP)
Length
339 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.663 kDa
Sequence
MASAALIDADMAPTLQSILDQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKHRKSVLLISTDPAHNLSDAFNQKFGKDARLVNGFDNLSAMEIDPNGSIQDLLASGAEEGQDPMAGLGGMGSMMQDLAFSIPGVDEAMSFAEVLKQVKSMSYEVIIFDTAPTGHTLRFLQFPTVMEKALSKVSQLSRQFGPMLNSFLGASGRLPNGQNMDELIEKMENLRETIGEVNGQFKDADLTTFVCVCIPEFLSLYETERMIQELNSYEIDTHSIVVNQLLFPKQDNPCEQCNARRKMQKKYLDQIEELYDEFNVVKMPLLVEEVRGKEKLEKFSEMLVKPFVPPQ

Gene
GET3
Protein
ATPase GET3
Organism
Rhodotorula glutinis
Length
339 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.271 kDa
Sequence
MASTAFVCAEPEGDALPPSLQNLLDQDSLKWIFVGGKGGVGKTTTSCSLAIQLAAVRESVLLISTDPAHNLSDAFSQKFGKEASKVNGFTNLFAMEIDPSASMQDMVESGDDSGMNGMMQDLAFAIPGIDEAMGFAEVMKHVKSMQFSAIVFDTAPTGHTLRFLSFPSVLEKALGKLSGLSGRFGPMLNQIGSMMGGGLNTSEMFEKLESMREVVTEVNAQFKNPDLTTFVPVMISEFLSLYETERLIQELTQYQIDVHDIVVNQLLYPENDSQCKHCKVRWTQQQKYLKEAYELYGEDFHIVRMPLLSQEVRGTDALKKCLLIEPYKAGQVVDLSASS

Gene
GET3
Protein
ATPase GET3
Organism
Uncinocarpus reesii (strain UAMH 1704)
Length
338 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
37.303 kDa
Sequence
MSSAVVPADDILEPTLQNILDQKSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLIDGFDNLSAMEIDPSASMQDLMAAGGDQAEDMGFGLGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKGLAKLSQLSSQFGPMLNSVLGARGGLPGGQNLDDVLSKMESLRETISEVNTQFKNADLTTFVCVCIAEFLSLYETERMIQELTSYHIDTHAIVVNQLLFPGKDSTCDQCKARRKMQKKYLNEIEELYEDFNVVRMPLLVEEVRGKEKLERFSDMLVHPYQPPQE

Gene
GET3
Protein
ATPase GET3
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
332 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
36.78 kDa
Sequence
MSSAAVVEDALEPTLQNILDQKTLKWLFVGGKGGVGKTTTSCSLAIQLSKVRESVLLISTDPAHNLSDAFGQKFGKEATKVNGFDNLSAMEIDPNSSIQEMIEQSDSQGGAMGSMMQDLAFAIPGVDEAMGFAEIMKHVKSMEYSVIVFDTAPTGHTLRFLSFPSVLEKALAKFSTLGRSLGPMLGQFQSMLGGGGPNQEDMFAKLESMREVITEVNTQFKDPEKTTFVCVCIAEFLSLYETERLIQELTSYEIDTHAIVCNQLLYPKKDSNCQHCRVRKQMQDKYVGEMMELYADDFHIVKMPLLTEEVRGTDKLKDFSNFLVTPYVPPTE

Gene
GET3
Protein
ATPase GET3
Organism
Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)
Length
331 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
36.71 kDa
Sequence
MATTTTVDDAQPPTLQNILDQKSLKWIFCGGKGGVGKTTTSCSLAIQLAKVRESVLLISTDPAHNLSDAFGQKFGREAVKVNGFSNLSAMEIDPTSSMQEMIEQSEQRGGALAPFMQDLAFAIPGVDEAMGFAEIMKLVKSMEYSVVVFDTAPTGHTLRFLSFPSVLEKALTKFSSFGKSLGPMFQQFQSMMGGGANAQEDMFAKLEGMRQVITEVNSQFKDETKTTFVCVCIAEFLSLYETERLIQELTQYGIDTHAIVCNQLLYPPPGSQCEHCRVRKAMQDKYVHEMMDLYAEDFNVVKIPLLTEEVRGPEKLSSLSEYLMHPYQPPQ

Gene
get3
Protein
ATPase get3
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
329 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
36.548 kDa
Sequence
MSFDPLPGTLENLLEQTSLKWIFVGGKGGVGKTTTSCSLAIQMSKVRSSVLLISTDPAHNLSDAFGTKFGKDARKVPGFDNLSAMEIDPNLSIQEMTEQADQQNPNNPLSGMMQDLAFTIPGIDEALAFAEILKQIKSMEFDCVIFDTAPTGHTLRFLNFPTVLEKALGKLGGLSSRFGPMINQMGSIMGVNANEQDLFGKMESMRANISEVNKQFKNPDLTTFVCVCISEFLSLYETERMIQELTSYEIDTHNIVVNQLLLDPNTTCPQCMARRKMQQKYLAQIEELYEDFHVVKVPQVPAEVRGTEALKSFSEMLVKPYVYPTSGKE

Gene
GET3
Protein
ATPase GET3
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
327 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
36.043 kDa
Sequence
MDEDSPAPSLQNIIDQDSLRWIFVGGKGGVGKTTTSCSLAIQLAKNRESVLLISTDPAHNLSDAFGQKFGKDARPVNGIDNLHCMEIDPSGSIQEMIEQAQSAGGAGAGMTNMMQDIAFSIPGVDEAMSFAEVLKQVKSTSYSVIIFDTAPTGHTLRFLTFPTVLEKALGKISELSGRFGPMLGSLMGGQGGPSADDMFAKLNETRATISEVNTQFKNPDLTTFVCVCIPEFLSLYETERMVQDLTSFDIDTHNIVVNQLLYPKKGDDCELCSSRYKMQQKYLEQILDLYEDFHIVRLPQQTQEVRGVQALEKFSNLLVHPYQHIEN

Gene
GET3
Protein
ATPase GET3
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
Length
326 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
36.029 kDa
Sequence
MASAALIDSDMEPTLQPILDQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKHRKSVLLISTDPAHNLSDAFNQKFGKDARLINGFDNLSAMEIDPNGSIQDLLAGGGESGEDAMAGLGGMGNMMQDLAFSIPGVDEAMSFAEVLKQVKSMSYEVIIFDTAPTGHTLRFLQFPTVMEKALSKVSQLSRQFGPMLNSFLGGGGRLPNGQNIDELVEKMEALRGTISEVNGQFKDADLTTFVCVCIPEFLSLYETERMIQELNSYEIDTHSIVVNQLLFPKQDNPCEQCNARRKMQKKYLEQIEELYDEFNVVKMPLLVEEVRGKEKLEK

Gene
get3
Protein
ATPase get3
Organism
Schizosaccharomyces japonicus (strain yFS275 / FY16936)
Length
324 amino acids
Function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Similarity
Belongs to the arsA ATPase family.
Mass
36.131 kDa
Sequence
MSLEPLPGTLENLLEQTSLKWIFVGGKGGVGKTTTSCSLAIQMSKVRKSVLLISTDPAHNLSDAFGTKFGKEARLIPGFENLSAMEIDPNASIQEMLEQSEQQNPNNPMSGMMQDLAFAIPGIDEALAFAEVMKEVKSMNFDCVIFDTAPTGHTLRFLNFPTVLEKALAKLSGLTSRFGPLINQMSGMLGTNTNQEDIFAKMEGMRGSISEVNKQFKNPDLTTFVCVCISEFLSLYETERMIQELTSYEIDTHNIVVNQLLLDPDTKCPQCIARRKMQQKYLSQIEELYEDFHIVKVPQVPSEVRGTEALTKFSDLLIHPYVKE