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GCS1

Gene
GCS1
Protein
Mannosyl-oligosaccharide glucosidase GCS1
Organism
Arabidopsis thaliana
Length
852 amino acids
Function
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor. Required for the accumulation of seed storage proteins, the formation of protein bodies, cell differentiation, cellulose biosynthesis and organization (in cell walls), cell shape determination and organization (e.g. epidermal cells), and embryo development. Involved in root development.
Similarity
Belongs to the glycosyl hydrolase 63 family.
Mass
97.634 kDa
Sequence
MTGASRRSARGRIKSSSLSPGSDEGSAYPPSIRRGKGKELVSIGAFKTNLKILVGLIILGIIVIYFVINRLVRHGLLFDESQKPRVITPFPAPKVMDLSMFQGEHKESLYWGTYRPHVYFGVRARTPLSLVAGLMWLGVKDEMYVMRHFCENSDDLSTFGWREHNGRDYGRQELVENDMVIETSFVKSKGDGLGYGGDWAVRIDVKNKGLNDDVKRSAHLFFYLADEGGNVLNLGQDGLDFQGSSLLVSGSREDVGDWQIHLKSQNQLETHYSGFKTPHIYNLSDLVQQNLALQARKFGRLQLSDTSEDSSNIYIFQISGRLPFTIDIPFISGIKGESSNVEKRLTSLTGLPLSDLLKKKHQEFDAKFNECFKLSEKHDSETLGVGRTAIANMLGGIGYFYGQSKIYVPKSTQPGSRDNFLLYWPAELYTAVPSRPFFPRGFLWDEGFHQLLIWRWDIRITLDIVGHWLDLLNIDGWIPREQILGAEALSKVPEEFVVQYPSNGNPPTLFLVIRDLIDAIRMEKFVASEKDEVLSFLERASVRLDAWFQWFNTSQKGKEIGSYFWHGRDNTTTQELNPKTLSSGLDDYPRASHPSEDERHVDLRCWMYLAADCMHSITELLGKEDKLSKENYNSTVKLLSNFNLLNQMHYDSDYGAYFDFGNHTEKVKLIWKEVIQENGQLSRQLVRKTFGKPKLKLVPHLGYVSFFPFMSRIIPPDSPILEKQLDLISNRSILWSDYGLVSLAKTSSMYMKRNTEHDAPYWRGPIWMNMNYMILSSLYHYSIVDGPYREKSKAIYTELRSNLIRNVVRNYYETGYIWEQYDQVKGTGKGTRLFTGWSALTLLIMSEDYPIF

Gene
GCS1
Protein
Glutamate--cysteine ligase
Organism
Candida albicans
Length
690 amino acids
Similarity
Belongs to the glutamate--cysteine ligase type 3 family.
Mass
79.19 kDa
Sequence
MGLLSIGTPLSWDESKKYNNHVRTNGITQLINIFKQHGYRENDVFLWGDEVEYMLVDFDETKKTARLSIDKDYIINDLNDPDKLLPIAEKQDVSYHPEYGRFMVEATPAKPYNGNLLSDYLYIEKNMIIRRQLCEDNLPSHIKLLTLTTFPRMGCNIFTSPPSKPDGIASQSLFLPDEIINRHARFPTLTANIRKRKGHKVAINLPIYPDKSTKLLDDTIPQNRELFDSDKEPWIGASKPGFIYMDSMGFGMGSSCLQITMQTKNISQARYLYDSLAPIAPIMLSLSAAAPIFKGFLVDQDVRWNVVSGAVDDRTFIEKGQEPYSGYHLFGGLDIDAQDKLRINNHQINQQGDLLDLYTKDGKPIQRVPQSRYDSIDNYLNDNYYDTKYFQDEYNDLNAPINEQVYQRLIDEGKLDKYMANHFAHLFIRDPLVIFSERINQDNNLENDHFENIQSTNWQTLRFKPPALYTKDTDLTTKPGWRVEFRPMEIQLTDFENAAYSSFITLLSKAILKFQPNFYIPLSKVEINMKLAHKVDSTLKDKFWFRSFELWNIDPQEFDDYGFEWFDQFINGNQQQNGHVNNNNNNDKKTKNDPIIVNGSTTTTNGTNSGSGITETNGTMLPKGCEGKTVEEINDVDDNGIDQRYTICQLINGSGEFPGFIKLVIKLIATDLVPQALNNSTISKEQLIEN

Gene
GCS1
Protein
Glutamate--cysteine ligase
Organism
Candida albicans
Length
690 amino acids
Similarity
Belongs to the glutamate--cysteine ligase type 3 family.
Mass
79.19 kDa
Sequence
MGLLSIGTPLSWDESKKYNNHVRTNGITQLINIFKQHGYRENDVFLWGDEVEYMLVDFDETKKTARLSIDKDYIINDLNDPDKLLPIAEKQDVSYHPEYGRFMVEATPAKPYNGNLLSDYLYIEKNMIIRRQLCEDNLPSHIKLLTLTTFPRMGCNIFTSPPSKPDGIASQSLFLPDEIINRHARFPTLTANIRKRKGHKVAINLPIYPDKSTKLLDDTIPQNRELFDSDKEPWIGASKPGFIYMDSMGFGMGSSCLQITMQTKNISQARYLYDSLAPIAPIMLSLSAAAPIFKGFLVDQDVRWNVVSGAVDDRTFIEKGQEPYSGYHLFGGLDIDAQDKLRINNHQINQQGDLLDLYTKDGKPIQRVPQSRYDSIDNYLNDNYYDTKYFQDEYNDLNAPINEQVYQRLIDEGKLDKYMANHFAHLFIRDPLVIFSERINQDNNLENDHFENIQSTNWQTLRFKPPALYTKDTDLTTKPGWRVEFRPMEIQLTDFENAAYSSFITLLSKAILKFQPNFYIPLSKVEINMKLAHKVDSTLKDKFWFRSFELWNIDPQEFDDYGFEWFDQFINGNQQQNGHVNNNNNNDKKTKNDPIIVNGSTTTTNGTNSGSGITETNGTMLPKGCEGKTVEEINDVDDNGIDQRYTICQLINGSGEFPGFIKLVIKLIATDLVPQALNNSTISKEQLIEN

Gene
gcs1
Protein
Glutamate--cysteine ligase
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
669 amino acids
Similarity
Belongs to the glutamate--cysteine ligase type 3 family.
Mass
76.523 kDa
Sequence
MGLLVLGTPLDWPESKKYCDYVRENGIMQFLHMYDTYISKKQDVLLWGDEIECIVVSMDDKSKKARVSLRQEDILNALGKYEETFRHVDFGPVYAALRNETCPKKIDAILSEVAKNPADYVERIGGNSNKDTIEITSSTKPHAQNAVPTFHPEYGRYMLESTPGAPYGSTLKDFTFVEYNMRLRRKIIENHLLPNELPLTITNFFRLGTPGFTDPEVEANGAISRSFFLPDDVINTHVRFPTLTANIRQRRGRKVAMNVPIFFDKNTIKPFHDPTVPWDRNLFPEDANARDGAALDNHIYMDSMGFGMGCCCLQITFQAKSCDEARLLYDQLTPITPLMLALSAGTPAFRGYLADQDCRWNVIAGAVDDRTEEEMKTVPKSRYDSVDLYISNDKRNLPEYNDVPVVINQDCYDKLIKDCIDERLAKHMAHIFSRDPLVIFSDSILQDNSVSNAHFENLNSTNWQSMRFKPPPPGSDIGWRVEFRSMEIQITDFENAAYSIFVVMLSRAILSFNLNLYMPISLVDENMKAAHARDAIHRKKFWFRCNPFPDASTDDESGQFRQLTIDELFNGEHRENGFPGLITIVRSYLYSCNPDAKTICLIERYIRLISQRANGQCLTAASWIRNFITTHPSYKQDSVVNDEINYDLIRRIAKIVDGDYDDTLLGKCS

Gene
GCS1
Protein
Ceramide glucosyltransferase
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
528 amino acids
Function
Catalyzes the final step in the biosynthesis of the membrane lipid glucosylceramide (GluCer), the transfer of glucose to ceramide (Probable). Glucosylceramides play important roles in growth, differentiation and pathogenicity. Contribution to fungal pathogenesis is host-dependent (PubMed:17908205).
Similarity
Belongs to the glycosyltransferase 2 family.
Mass
59.553 kDa
Sequence
MYSFIECIAGALFVLGCVVVTLVVIGVRALLYNFRNRPAPPLSSQLGQNAPHVTIIRPVKGLEPRLYDCIAASFRQDYPQDKVSIRLCLEDDTDPAYPVLQKVIEDFPTIDARIMLEKEDHVLSETVNMGPNPKIRNLSRAYREAKGDIVWIIDCNIWMAKGVLGRMVDKLMGYRVGGAAKPYKFVHQLPIVVDLMDFSTSLAAEGRSLLDASPEEDHPTEDLGAEEFPKVMSHGGGRIDEMFMTTSHAKFYSAINTLRAAPCAVGKSNMFRKSQLDQATDAILNPKLDQSKNLPTGVDYFSHNICEDHLIGEALWTTDFPGYKSHGLVWGDIAVQPVSGMSVQAYTARRSRWLRARKYTVLSATILEPFTECFLFATYMSLAMTTIPVLSQNLGIPKTWNATAIAWFTITTLWMLIDYIGYLRLHSGVTMEVDEHTPYFAKGFKNTGGIKRRPFLEFLAAWIGREGLAFPVWAYAVVFGNTVNWRGRLFYIHWDTTVDAVEPREERTREVRTPELERGPSRNKHRVD

Gene
GCS1
Protein
Ceramide glucosyltransferase
Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)
Length
450 amino acids
Function
Catalyzes the final step in the biosynthesis of the membrane lipid glucosylceramide (GluCer), the transfer of glucose to ceramide. Glucosylceramides play important roles in growth, differentiation and pathogenicity. Essential factor in determining the success of fungal infection by regulating survival of yeast cells during the initial colonization of the host lung.
Similarity
Belongs to the glycosyltransferase 2 family.
Mass
49.721 kDa
Sequence
MSDSGTLSLIGGIVFLVLWVVVWSICLLGWRTARIRYAHPNIPSRLSKLPVSSAPGVTIIRPLCGLDQNLYNTLESVMKLDYPKFEVIFAVQDEKDEALPVVNMVMEKYPEVEAKVIIDSRKVGVNPKVNNLMTPFQEAKYDLLWILDSTCSVLPGTLGRSVEAFFSNTSSTASPYDPESSPLLSISDDVRKPPIAGEVGLVHQVPIAVCYQKTWGSLIEQAYLNTTHAKMYLAINATSIDSCVVGKSCMYSRDNISHLTTPSPSLRSLPDPPSGLAGFGPFLAEDNMIGLSLWHELKLKHAMTSDVVLDFIGSLSVRDYINRRVRWIRVRKKMTLAATLLEPLTESIISGLYGAWAISRLLGGNILPLFLLHMAAWISVDISTKRALETNIKGIGPPESKVTFLMAWAARECLALPIWMLAMTSSEVVWRGQKYKIIASGEAIRLGDRN

Gene
GCS1
Protein
ADP-ribosylation factor GTPase-activating protein GCS1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
352 amino acids
Function
GTPase-activating protein (GAP) for ARF1 and ARF2. Involved in intracellular vesicular transport. Required for transport from the trans-Golgi network. Implicated in the regulation of retrograde transport from the Golgi to the ER and in actin cytoskeletal organization. May be involved in the maintenance of mitochondrial morphology, possibly through organizing the actin cytoskeleton in Saccharomyces.
Mass
39.296 kDa
Sequence
MSDWKVDPDTRRRLLQLQKIGANKKCMDCGAPNPQWATPKFGAFICLECAGIHRGLGVHISFVRSITMDQFKPEELLRMEKGGNEPLTEWFKSHNIDLSLPQKVKYDNPVAEDYKEKLTCLCEDRVFEEREHLDFDASKLSATSQTAASATPGVAQSREGTPLENRRSATPANSSNGANFQKEKNEAYFAELGKKNQSRPDHLPPSQGGKYQGFGSTPAKPPQERSAGSSNTLSLENFQADPLGTLSRGWGLFSSAVTKSFEDVNETVIKPHVQQWQSGELSEETKRAAAQFGQKFQETSSYGFQAFSNFTKNFNGNAEDSSTAGNTTHTEYQKIDNNDKKNEQDEDKWDDF