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GCN5

Gene
GCN5
Protein
Histone acetyltransferase GCN5
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
546 amino acids
Function
Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).
Similarity
Belongs to the acetyltransferase family. GCN5 subfamily.
Mass
63.512 kDa
Sequence
MVTRRRLHHPEVEQVSKRQKVDKAESKNKKHADVAAERGEQSTEDHEDESQDKKDKKVVGDNRDEDEEVSPNGQEAAEDNDDRKDKDAKEKDTETNDEGTEKSHTDVNDDDDDVDESKEEDAAAAVDITKEKKDEQESDNKTEEKKVQENEEEEEEDENKNDEDVEELGSTEPVDDEKKGLVKFEFDGVEYKFKERASVIEENEGKIEFRVVSNDNTRENMMVLTGLKNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYKPFNKRQFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRNTSDIRYFLTYADNYAIGYFKKQGFTKDITLDKKVWMGYIKDYEGGTLMQCSMLPRIRYLDAAKILLLQEAALRRKIRTISKSHVVHPGLECFNDIENIKPIDPMSIPGLKEAGWTPEMDELAQRPKRGPHYAAIQNILVELQNHAAAWPFLRPVNKEEVPDYYEFIKEPMDLSTMELKLENNKYEKMEEFIYDARLVCNNCRLYNGENTSYYKYANRLEKFFNNKVKEIPEYSHLID

Gene
GCN5
Protein
Histone acetyltransferase GCN5
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
516 amino acids
Function
Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).
Similarity
Belongs to the acetyltransferase family. GCN5 subfamily.
Mass
59.291 kDa
Sequence
MPPKRRHHGAGRVQNKRGKVDTVKEEIKPKDEPVETEIDGGSAVDEDVTDDLEHKTSKEDQKEDQKEEDGPIDAQNGTSETKVAGESVKTVEDKIESVTTNEEVVESPVNDYNASSTTTKAEEKQLEEEANEKTDTSPIVENEVVDEEAGTTKFDFDGQEYSYKDRPSVIEEKEGKIEFRVVNNDNSKENMMVLTGLKNIFQKQLPKMPKEYIARLVYDRSHLSMAVVRKPLTVVGGITYRPFDKREFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRATSPIKYFLTYADNYAIGYFKKQGFTKEITLDKNVWMGYIKDYEGGTLMQCSMLPRIRYLDAAKILLLQEAAIRRKIRSISQSHIVRPGLKQFLDLDNIKPIDPMTIPGLKEAGWTPEMDELAQRPKRGPHYAAMQNLLTELQNHAAAWPFLQPVNKEEVPDYYEFIKEPMDLSSMEMKLNGNRYEKMENFIYDARLIFNNCRAYNGENTSYFKYANRLEKFFNSKVKEIPEYSHLVD

Gene
GCN5
Protein
Histone acetyltransferase GCN5
Organism
Oryza sativa subsp. japonica
Length
511 amino acids
Function
Acetylates histone H3. Acetylation of histones gives a specific tag for epigenetic transcription activation. Operates in concert with certain DNA-binding transcriptional activators. Acts via the formation of large multiprotein complexes that modify the chromatin (By similarity).
Similarity
Belongs to the acetyltransferase family. GCN5 subfamily.
Mass
56.685 kDa
Sequence
MDGLAAPSPSHSGATSGGGASHRKRKLPPSSLSDATADEDDDTTAPSSPSTSPSSPSRPSSPSSSHSDDDDDDSLHTFTAARLDGAPPSSSGRPPKPESSTVSAAAAAAAAAAAPKPDSASAAAGDGKEDPKGLFTDNIQTSGAYSAREEGLKREEEAGRLKFLCYSNDGVDEHMIWLVGLKNIFARQLPNMPKEYIVRLVMDRTHKSMMVIRNNIVVGGITYRPYTSQKFGEIAFCAITADEQVKGYGTRLMNHLKQHARDADGLTHFLTYADNNAVGYFVKQGFTKEITLDKERWQGYIKDYDGGILMECRIDQKLPYVDLATMIRRQRQAIDEKIRELSNCHIVYSGIDFQKKEAGIPRRTMKPEDIQGLREAGWTPDQWGHSKSRSAFSPDYSTYRQQLTNLMRSLLKNMNEHPDAWPFKEPVDSRDVPDYYDIIKDPIDLKTMSKRVESEQYYVTLEMFVADMKRMFSNAKTYNSPDTIYYKCASRLESFFSNKVASQLAQASTKN

Gene
GCN5
Protein
Histone acetyltransferase GCN5
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
464 amino acids
Function
Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).
Similarity
Belongs to the acetyltransferase family. GCN5 subfamily.
Mass
54.096 kDa
Sequence
MDSDTESVKRRKSSGSESESSVRDPKRTKIEDEDFQENGIDDEDEEEEEEEAKDEGDEDDEEKGEDDEEDDEEKEGEDGEGEEEDEEEDEEKKREEEEKYVTSFNFDGVEYKYKERPAVIEEREGKIEFRVVNNDNSKENLMILTGLKNIFQKQLPKMPREYIARLVYDRSHVSMAVVRKPLTVVGGITFRPFDTRKFAEIVFCAISSTEQVRGYGAHLMNHLKDYVKATSPVMYFLTYADNYAIGYFKKQGFSKEISLDRSVWMGYIKDYEGGTLMQCSMLPRIRYLDVNKILLLQKALIHKKIRAISKSHVVRKGLDHFRDSTTPVDPMTIPGLKEAGWTPEMDELARRPKRGPHFAVMQHVLSELQNHASAWPFAQAVNRDEVPDYYEVIKEPMDLSTMEQRLEADSYKTMEEFVYDARLVFNNCRAYNNETTTYYKNANKLEKFMVAKIKEIPEYSHLVE

Gene
GCN5
Protein
Histone acetyltransferase GCN5
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
455 amino acids
Function
Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).
Similarity
Belongs to the acetyltransferase family. GCN5 subfamily.
Mass
52.412 kDa
Sequence
MVDRKRNSSVISDNEENGRVDKKTKIKDEIEGDEVERDVKNEEANGADTDDKEEVRKDNEEENAENGGGEGDDDDDDDDEAEEEKKRTTTFNFDGVTYSFKERPSVLEEKEGKIEFRVVNNDNTKESLMVLTGLKNIFQKQLPKMPREYISRLVYDRSHLSMAVVRKPLTVVGGITYRPFDNREFAEIVFCAISSTEQVRGYGAHLMNHLKDYCRATSNVKYFLTYADNYAIGYFKKQGFNKEITLDKSVWMGYIKDYEGGTLMQCSMLPPILRYLDSAKILLLQKAAIEKKIKLRSKAHVVRPGLQVFKTNKDAKLNPAKDIPGLAESGWSEEMDKLAQKPKRGPHYNFMVTLLSELTNHPSAWPFSTPVNKEEVGDYYDVIKEPMDLSTMESKLENDKYDSFDQFLYDARLIFNNCRSYNADSTTYFKNATKLEKFMNNKIKDSAEYSHFLDQ

Gene
gcn5
Protein
Histone acetyltransferase gcn5
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
454 amino acids
Function
Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, and with a lower preference histone H4 to form H4K8ac and H4K16ac. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).
Similarity
Belongs to the acetyltransferase family. GCN5 subfamily.
Mass
51.976 kDa
Sequence
MSNSLNDQTRPPDSSVVDSTSSNFPNASNDSVHDKPVKQDEQSNPNVREAIANSDGQESLAVKENKDTESSSSHFVPNGVSNSKKRKLVATDLDVDFDISSVRVTEKPSVLEEKSGVIQFRVVSNDDTADSMIMLTGLKNIFMKQLPKMPKEYITRLIYDRNHLSMTIVKDNLHVVGGITYRPFEQRGFAEIVFCAIASNEQVRGYGSHLMNHLKDYVRGTTTIQHFLTYADNYAIGYFKKQGFTKEITLDKSIWVGYIKDYEGGTLMQCTMIPKIKYLEANLILAIQKAAVVSKINRITRSNVVYPGLDVFKDGPAHIEPSQVPGLMEVGWCKEMEELSKKPRPKPFFAVLEMLFTEMQNHPSSWPFMQPVSKEDVPDYYEVIEHPMDLSTMEFRLRNNQYESVEEFIRDAKYIFDNCRSYNDSNTTYYKNADRLEKFFQKKLRETEYSHLAD

Gene
GCN5
Protein
Histone acetyltransferase GCN5
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
452 amino acids
Function
Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).
Similarity
Belongs to the acetyltransferase family. GCN5 subfamily.
Mass
52.414 kDa
Sequence
MSMPLKRRNKQSQGNEPKKIKVEEQEAEEKISEDIPVTDLKEPEALADIQSTSGGDEVSEGAQGDADPAEKSVGGLKEEVEDEEKGIVKFMFDGVEYKFRERPSVIEEKEGKIEFRVVNNDNTRENMMVLTGLKNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYRPFEKGEFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRATTNIKYFLTYADNYAIGYFKKQGFTKEITLDKSVWMGYIKDYEGGTLMQCFMLPRIRYLDAAKILLLQEAAIQRKIRTISRSHIVRPGLRQFEDLDNIEPIDPMSVPGLREAGWTPEMDELAQRPKRGPHYATMQNVLTELQNHAAAWPFLQPVNRDEVPDYYEFIKEPMDLSTMEIKLENNRYEKMEDFIYDARLIFNNCRAYNGENTSYFKYANRLEKFFNTKMKEIPEYSHLLD

Gene
GCN5
Protein
Histone acetyltransferase GCN5
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
439 amino acids
Function
Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K9ac, H3K14ac, H3K18ac, H3K23ac, H3K27ac and H3K36ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Operates in concert with certain DNA-binding transcriptional activators such as GCN4 or HAP2/3/4. Its acetyltransferase activity seems to be dependent on the association in different multisubunit complexes. Functions as histone acetyltransferase component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. The ADA histone acetyltransferase complex preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B, leading to transcription regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.
Similarity
Belongs to the acetyltransferase family. GCN5 subfamily.
Mass
51.069 kDa
Sequence
MVTKHQIEEDHLDGATTDPEVKRVKLENNVEEIQPEQAETNKQEGTDKENKGKFEKETERIGGSEVVTDVEKGIVKFEFDGVEYTFKERPSVVEENEGKIEFRVVNNDNTKENMMVLTGLKNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYRPFDKREFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRNTSNIKYFLTYADNYAIGYFKKQGFTKEITLDKSIWMGYIKDYEGGTLMQCSMLPRIRYLDAGKILLLQEAALRRKIRTISKSHIVRPGLEQFKDLNNIKPIDPMTIPGLKEAGWTPEMDALAQRPKRGPHDAAIQNILTELQNHAAAWPFLQPVNKEEVPDYYDFIKEPMDLSTMEIKLESNKYQKMEDFIYDARLVFNNCRMYNGENTSYYKYANRLEKFFNNKVKEIPEYSHLID