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GCH1

Gene
GCH1
Protein
GTP cyclohydrolase 1
Organism
Arabidopsis thaliana
Length
466 amino acids
Function
GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.
Similarity
Belongs to the GTP cyclohydrolase I family.
Mass
51.38 kDa
Sequence
MGALDEGCLNLELDIGMKNGCIELAFEHQPETLAIQDAVKLLLQGLHEDVNREGIKKTPFRVAKALREGTRGYKQKVKDYVQSALFPEAGLDEGVGQAGGVGGLVVVRDLDHYSYCESCLLPFHVKCHIGYVPSGQRVLGLSKFSRVTDVFAKRLQDPQRLADDICSALQHWVKPAGVAVVLECSHIHFPSLDLDSLNLSSHRGFVKLLVSSGSGVFEDESSNLWGEFQSFLMFKGVKTQALCRNGSSVKEWCPSVKSSSKLSPEVDPEMVSAVVSILKSLGEDPLRKELIATPTRFLKWMLNFQRTNLEMKLNSFNPAKVNGEVKEKRLHCELNMPFWSMCEHHLLPFYGVVHIGYFCAEGSNPNPVGSSLMKAIVHFYGFKLQVQERMTRQIAETLSPLVGGDVIVVAEAGHTCMISRGIEKFGSSTATIAVLGRFSSDNSARAMFLDKIHTTNALKTESSSPF

Gene
GCH1
Protein
GTP cyclohydrolase 1
Organism
Solanum lycopersicum
Length
456 amino acids
Function
GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.
Similarity
Belongs to the GTP cyclohydrolase I family.
Mass
49.951 kDa
Sequence
MGALDEGHYHAEIDNEVSFELGFETQPETLVIQDAVRVLLQGLGEDINREGIKKTPFRVAKALRQGTRGYKQKVNDIVHGALFPEAGLEGGSGQAGGVGGLVIVRDLDLFSYCESCLLPFQVKCHVGYVPSGKRVVGLSKLSRVADIFAKRLQSPQRLADEVCTALQHGIKPTGVAVVLQCMHIHFPNFESAFLDSTSQGWVKITATSGSGVFEDGNADVWTDFWSLLKFRGISIDNAHRRSSGQSWCPSQSCGMPGQANSAMTNAVNSILKSLGEDPLREELVETPSRFVKWFMNFRNSNLEMKLNGFVRSRIDTRSPQGGNFNDGICSELNLSFWSQCEHHLLPFQGVVHIGYHSSDGVNPVGRPLVQSVVHFYGFKLQVQERVTRQIAETVSSFLGEDIIVVVEANHTCMISRGIEKFGSNTATFAVLGRFSTDPVARAKFLQSLPDSGSAGR

Gene
GCH1
Protein
GTP cyclohydrolase 1
Organism
Homo sapiens
Length
250 amino acids
Function
Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.
Similarity
Belongs to the GTP cyclohydrolase I family.
Mass
27.903 kDa
Sequence
MEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEAKSAQPADGWKGERPRSEEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRS

Gene
Gch1
Protein
GTP cyclohydrolase 1
Organism
Rattus norvegicus
Length
241 amino acids
Function
May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence.
Similarity
Belongs to the GTP cyclohydrolase I family.
Mass
27.057 kDa
Sequence
MEKPRGVRCTNGFPERELPRPGASRPAEKSRPPEAKGAQPADAWKAGRPRSEEDNELNLPNLAAAYSSILRSLGEDPQRQGLLKTPWRAATAMQFFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGRVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALQPAGVGVVIEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRS

Gene
Gch1
Protein
GTP cyclohydrolase 1
Organism
Rattus norvegicus
Length
241 amino acids
Function
May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence.
Similarity
Belongs to the GTP cyclohydrolase I family.
Mass
27.057 kDa
Sequence
MEKPRGVRCTNGFPERELPRPGASRPAEKSRPPEAKGAQPADAWKAGRPRSEEDNELNLPNLAAAYSSILRSLGEDPQRQGLLKTPWRAATAMQFFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGRVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALQPAGVGVVIEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRS

Gene
Gch1
Protein
GTP cyclohydrolase 1
Organism
Mus musculus
Length
241 amino acids
Function
May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence.
Similarity
Belongs to the GTP cyclohydrolase I family.
Mass
27.014 kDa
Sequence
MEKPRGVRCTNGFSERELPRPGASPPAEKSRPPEAKGAQPADAWKAGRHRSEEENQVNLPKLAAAYSSILLSLGEDPQRQGLLKTPWRAATAMQYFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGRVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALQPAGVGVVIEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRS

Gene
GCH1
Protein
GTP cyclohydrolase 1
Organism
Gallus gallus
Length
236 amino acids
Function
May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence.
Similarity
Belongs to the GTP cyclohydrolase I family.
Mass
26.115 kDa
Sequence
MAAARSCNGYARREGPPSPKLGTEKPRVSAGSGGSGDGWRGERPRSEEDNELSLPSLAAAYTTILRALGEDPERQGLLKTPWRAATAMQFFTKGYQETIADVLNDAIFDEDHDEMVIVKNIDMFSLCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAIAITEALQPAGVGVVIEATHMCMVMRGVQKMNSKTATSTMLGVFREDPKTREEFLTLIRS

Gene
gch1
Protein
GTP cyclohydrolase 1
Organism
Oncorhynchus mykiss
Length
225 amino acids
Function
May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence.
Similarity
Belongs to the GTP cyclohydrolase I family.
Mass
25.168 kDa
Fragment
single
Sequence
MERSKQSHDNQADSRPTTNESSLNGHFDGLVKKTPGMWDVKGRGTAGESSSHTGSSVVENWKHERTRSIEDNEMSLPSLAAAYTTIIRGLGKDPQRQGLLKTPWRAATAMQFFTKGYQEKIIDVLNDAILDEDHDEMVIVKDIDMFSMCEHHLVPIFGRVHIGYLPNKRVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALQPAGVGVVIEATHMCMVMRG