Fjoh_3169

L-lysine 4-hydroxylase

370 amino acids

Alpha-ketoglutarate-dependent dioxygenase that in vitro catalyzes the regio- and stereoselective hydroxylation of L-lysine, leading to (4R)-4-hydroxy-L-lysine. To a lesser extent, can also use (3S)-3-hydroxy-L-lysine as substrate, producing the dihydroxylated product (3R,4R)-3,4-hydroxy-L-lysine. Cannot use D-lysine or L-ornithine as substrate.

Belongs to the clavaminate synthase family.

42.002 kDa

MKSQSLIEDEIPVKENYAYQIPTSPLIVEVTPQERNILSNVGALLEKAFKSYENPDYIEALHLYSFQLLPERIARILSRFGTDFSADQYGAIIFRGLLEVDQDHLGPTPANWQSADYSKLNKYGFICSLLHGAVPSKPVQYYAQRKGGGILHAVIPDEKMAATQTGSGSKTNLYVHTEDAFLLHQADFLSFLYLRNEERVPSTLYSVRSHGKVNKIMEKLFDPIYQCPKDANYQEEINDGPLASVLYGNKKLPFIRFDAAEQIFNENAGQTPEALYNLTEFWNEAKELINSDYIPDSGDVIFVNNHLCAHGRSAFTAGQKEENGKLVPCERRQMLRMMSKTSLIHIRSMTHTDDPYFVMEEHLGKVFDQA